BCL6 and ZBTB16

Number of citations of the paper that reports this interaction (PubMedID 11175338)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		BCL6	ZBTB16
Description		BCL6 transcription repressor	zinc finger and BTB domain containing 16
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Replication Fork Nucleolus Golgi Apparatus Paraspeckles	Male Germ Cell Nucleus Nucleus Cytosol Nuclear Body PML Body Nuclear Speck Transcription Repressor Complex Protein-containing Complex
	Molecular Function	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intronic Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Chromatin DNA Binding Identical Protein Binding Sequence-specific DNA Binding Metal Ion Binding DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity Protein Binding Zinc Ion Binding Protein Domain Specific Binding Type 2 Angiotensin Receptor Binding Identical Protein Binding Protein Homodimerization Activity Metal Ion Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis Regulation Of Cytokine Production Negative Regulation Of Cell-matrix Adhesion Plasma Cell Differentiation Immune System Process Germinal Center Formation Regulation Of Germinal Center Formation Regulation Of Immune System Process Negative Regulation Of Type 2 Immune Response Negative Regulation Of B Cell Apoptotic Process Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Inflammatory Response DNA Damage Response Cell-matrix Adhesion Rho Protein Signal Transduction Spermatogenesis Intracellular Protein Localization Cell Population Proliferation Pyramidal Neuron Differentiation Actin Cytoskeleton Organization B Cell Differentiation Negative Regulation Of Cell Growth Positive Regulation Of B Cell Proliferation Heterochromatin Formation Negative Regulation Of Mast Cell Cytokine Production Mononuclear Cell Proliferation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Rho Protein Signal Transduction Type 2 Immune Response B Cell Proliferation Regulation Of Cell Population Proliferation Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Regulation Of Memory T Cell Differentiation T-helper 2 Cell Differentiation Regulation Of T Cell Differentiation Positive Regulation Of Regulatory T Cell Differentiation Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Negative Regulation Of T-helper 2 Cell Differentiation Positive Regulation Of Neuron Differentiation Negative Regulation Of Notch Signaling Pathway Negative Regulation Of DNA-templated Transcription Isotype Switching To IgE Isotypes Negative Regulation Of Isotype Switching To IgE Isotypes Erythrocyte Development Cell Motility Regulation Of Inflammatory Response Regulation Of Immune Response Positive Regulation Of Lymphocyte Activation Negative Regulation Of Plasma Cell Differentiation Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Mitotic Cell Cycle DNA Replication Positive Regulation Of Cell Motility Negative Regulation Of Cellular Senescence	Negative Regulation Of Transcription By RNA Polymerase II Skeletal System Development Mesonephros Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Apoptotic Process Central Nervous System Development Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Embryonic Pattern Specification Anterior/posterior Pattern Specification Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Protein Ubiquitination Hemopoiesis Myeloid Cell Differentiation Positive Regulation Of Chondrocyte Differentiation Protein Localization To Nucleus Embryonic Hindlimb Morphogenesis Forelimb Morphogenesis Hindlimb Morphogenesis Embryonic Digit Morphogenesis Positive Regulation Of Apoptotic Process Ossification Involved In Bone Maturation Regulation Of Cell Differentiation Positive Regulation Of Fat Cell Differentiation Negative Regulation Of Myeloid Cell Differentiation Positive Regulation Of Ossification Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Male Germ-line Stem Cell Asymmetric Division Positive Regulation Of NK T Cell Differentiation Cartilage Development Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Cartilage Development Regulation Of Multicellular Organismal Development
Pathways		Interleukin-4 and Interleukin-13 signaling TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain FOXO-mediated transcription of cell death genes	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Hairy-cell leukemia	Skeletal defects, genital hypoplasia, and mental retardation Acute myeloid leukemia (AML)
GWAS		Adverse response to drug ( 30420678) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 31361310) Allergic sensitization ( 23817571) Appendicular lean mass ( 33097823) Asthma ( 31959851) B cell non-Hodgkin lymphoma ( 23749188) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 32888494 27863252) Blood urea nitrogen levels ( 29403010) Glucose homeostasis traits ( 25524916) Granulocyte percentage of myeloid white cells ( 27863252) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Monocyte percentage of white cells ( 32888494) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) PR interval ( 23534349) Pulmonary function (smoking interaction) ( 23284291) Renal function-related traits (BUN) ( 22797727) Selective IgA deficiency ( 27723758) Self-reported allergy ( 23817569) Triglyceride levels ( 32203549) Type 2 diabetes ( 25760438)	Basophil count ( 32888494) Chronotype ( 30696823) Conduct disorder (maternal expressed emotions interaction) ( 18846501) Corneal astigmatism ( 29422769) Diisocyanate-induced asthma ( 25918132) Granulocyte count ( 27863252) Granulocyte percentage of myeloid white cells ( 27863252) Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean platelet volume ( 27863252 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494 27863252) Myeloid white cell count ( 27863252) Neutrophil count ( 32888494 27863252) Neutrophil percentage of white cells ( 32888494) Non-glioblastoma glioma ( 28346443 26424050) Paneth cell defects in Crohn's disease ( 28352666) Platelet count ( 32888494 27863252) Plateletcrit ( 32888494 27863252) Polycystic ovary syndrome ( 26284813 30566500) Polycystic ovary syndrome (adjusted for age and BMI) ( 34791234) Polycystic ovary syndrome (adjusted for age) ( 34791234) Red blood cell count ( 32888494) Smoking initiation ( 33082346) Sum basophil neutrophil counts ( 27863252) Sum neutrophil eosinophil counts ( 27863252) Urinary albumin-to-creatinine ratio ( 32600054) White blood cell count ( 27863252 32888494)
Interacting Genes		91 interacting genes: ANKRD53 ARHGEF9 ARRDC3 ATP23 BCL11A BCL6B BCOR BLZF1 CABP4 CDK19 CDK8 CFAP161 CFAP97D1 CHD3 CNOT2 CRBN CREBBP CTNNB1 CUTC DVL2 ENO1 EP300 FBXO11 GATA1 GLRX3 GOLGA2 HDAC1 HDAC4 HDAC5 HDAC7 HDAC9 IHO1 IRF4 JUN JUNB JUND KIFC3 KLHL12 KLHL20 KRTAP13-1 KRTAP13-2 KRTAP19-1 LIMS3 LIMS4 MAPK1 MDFI MED17 MED6 MTA3 MTUS2 NCOR1 NCOR2 PAK1 PBX4 PELI1 PFDN5 PIN1 PML POF1B PPARD PPTC7 PRKD3 PSMB4 RAF1 REL RUNX1T1 SIAH1 SIN3A SNCA SP1 SPI1 SPMIP2 SPMIP4 SPMIP6 SSX2IP TEKT4 TFIP11 TLE5 TP53 TP53BP1 TRAF1 TRAF2 TRIB3 TWIST1 WDR83 WNK4 ZBTB16 ZBTB17 ZBTB7A ZBTB7B ZNHIT1	155 interacting genes: ACP5 ADAMTS4 AGTR2 AMOTL2 ANAPC5 ANXA7 ATP6AP2 ATP7B BCL6 BLZF1 BMI1 CARD9 CASP3 CCDC85B CCHCR1 CD81 CDK1 CDK4 CDKN1A CEBPA CEP70 CEP72 CFH CIDEA COG6 COQ6 CRBN CTDSP1 DLST DNAAF5 DNM2 DPM1 EEF1A1 EFHC2 EIF2S2 ENOX1 EP300 EPN1 ERVK-6 ESR1 FAM217B FAM90A1 FCHO1 FHL2 FHL5 FSHR GATA1 GATA2 GCSH GNAO1 GNE GOLGA2 GOLGA6L9 GPANK1 GRB7 GSTM4 HBEGF HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC9 HDX HOXA1 HOXC5 HSF2BP ICAM3 IL6 KIAA1549 KIFC3 KRT40 KRTAP4-12 LAMTOR5 LDOC1 LMTK3 LRIG1 LSM2 LYAR MAGEA11 MAP3K3 MCUB MEOX2 MID2 MTUS2 MX1 MYLIP NCOR1 NCOR2 NFKBID NME4 NR3C1 OSBPL3 PAFAH1B3 PARP1 PGAM5 PHF1 PIAS2 PIBF1 PLSCR1 PMAIP1 PML PNRC2 PRKAR1B PSMD11 PSMD2 QTRT1 RAB27A RAB3IP RARA RB1 REL RFLNB RINT1 RUNX1T1 RXRA SH2D4A SIN3A SIN3B SMAD3 SMN1 SP1 SPOP SPRY2 SUMO1 TAB2 TERF1 THNSL2 TK1 TLE5 TOLLIP TRAF1 TRAF2 TRAF4 TRIM21 TRIM23 TRIM27 TRIM54 TTC23 TXNIP UBE2I VDR VTA1 WASHC1 WDR33 YJU2B ZBTB32 ZBTB42 ZNF24 ZNF281 ZNF552 ZNF620 ZNF655
Entrez ID		604	7704
HPRD ID		00180	11762
Ensembl ID		ENSG00000113916	ENSG00000109906
Uniprot IDs		B5B0A5 P41182	A0A024R3C6 A0A0S2Z4J5 Q05516
PDB IDs		1R28 1R29 1R2B 2EN2 2EOS 2LCE 2YRM 3BIM 3E4U 3LBZ 4CP3 4U2M 5H7G 5H7H 5MW2 5MW6 5MWD 5N1X 5N1Z 5N20 5N21 5X4M 5X4N 5X4O 5X4P 5X4Q 5X9O 5X9P 6C3L 6C3N 6CQ1 6EW6 6EW7 6EW8 6TBT 6TCJ 6TOF 6TOG 6TOH 6TOI 6TOJ 6TOK 6TOL 6TOM 6TON 6TOO 6XMX 6XWF 6XXS 6XYX 6XZZ 6Y17 6ZBU 7BDE 7GUD 7GUE 7GUF 7GUG 7GUH 7GUI 7GUJ 7GUK 7GUL 7GUM 7GUN 7GUO 7GUP 7GUQ 7GUR 7GUS 7GUT 7GUU 7GUV 7GUW 7GUX 7GUY 7GUZ 7GV0 7GV1 7GV2 7GV3 7GV4 7GV5 7GV6 7GV7 7GV8 7GV9 7GVA 7GVB 7GVC 7GVD 7GVE 7GVF 7GVG 7GVH 7GVI 7GVJ 7GVK 7GVL 7GVM 7GVN 7GVO 7GVP 7GVQ 7GVR 7GVS 7GVT 7GVU 7GVV 7GVW 7GVX 7GVY 7GVZ 7GW0 7GW1 7GW2 7GW3 7GW4 7GW5 7GW6 7GW7 7GW8 7GW9 7GWA 7GWB 7GWC 7GWD 7GWE 7GWF 7GWG 7GWH 7GWI 7GWJ 7GWK 7GWL 7GWM 7GWN 7GWO 7GWP 7GWQ 7GWR 7GWS 7GWT 7GWU 7GWV 7GWW 7GWX 7GWY 7GWZ 7GX0 7GX1 7GX2 7GX3 7GX4 7GX5 7GX6 7GX7 7GX8 7GX9 7GXA 7GXB 7GXC 7GXD 7GXE 7GXF 7GXG 7GXH 7GXI 7GXJ 7GXK 7GXL 7GXM 7GXN 7GXO 7GXP 7GXQ 7GXR 7GXS 7GXT 7GXU 7GXV 7GXW 7GXX 7GXY 7GXZ 7GY0 7GY1 7GY2 7GY3 7LWE 7LWF 7LWG 7LZQ 7LZR 7LZS 7OKD 7OKE 7OKF 7OKG 7OKH 7OKI 7OKJ 7OKK 7OKL 7OKM 7Q7R 7Q7S 7Q7T 7Q7U 7Q7V 7QK0 7RUW 7RUX 7RUY 7RUZ 7RV0 7RV1 7RV2 7RV3 7RV4 7RV5 7RV6 7RV7 7RV8 7RV9 7T0S 7T0T 7T0U 7ZWN 7ZWO 7ZWP 7ZWQ 7ZWR 7ZWS 7ZWT 7ZWU 7ZWV 7ZWW 7ZWX 7ZWY 7ZWZ 8AS9 8C78	1BUO 1CS3 8YTH
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Metabolic Process Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Histone Deacetylase Binding Transcription Repressor Complex DNA-binding Transcription Factor Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Negative Regulation Of Metabolic Process Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Transcription Corepressor Activity Regulation Of Signal Transduction Negative Regulation Of Macromolecule Biosynthetic Process Regulation Of Intracellular Signal Transduction Nucleoplasm Positive Regulation Of RNA Metabolic Process Negative Regulation Of Biosynthetic Process Regulation Of Primary Metabolic Process Positive Regulation Of Biosynthetic Process Transcription Cis-regulatory Region Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Transcription Regulator Complex Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Macromolecule Biosynthetic Process Histone Deacetylase Activity, Hydrolytic Mechanism Regulation Of Cell Differentiation Positive Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Histone Deacetylase Complex Regulation Of Macromolecule Metabolic Process Regulation Of Developmental Process Protein Lysine Deacetylase Activity Transcription Corepressor Binding Positive Regulation Of Metabolic Process Transcription Coactivator Binding Chromatin Organization Negative Regulation Of Developmental Process	Histone Deacetylase Activity, Hydrolytic Mechanism Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Transcription By RNA Polymerase II Protein Lysine Deacetylase Activity Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of RNA Metabolic Process Regulation Of Macromolecule Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Histone Deacetylase Activity Histone Deacetylase Complex Regulation Of Primary Metabolic Process Histone Deacetylase Binding Regulation Of Gene Expression RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Transcription By RNA Polymerase II Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Cytoplasm Nucleoplasm DNA-binding Transcription Factor Binding Zinc Ion Binding Negative Regulation Of Gene Expression Nucleus Protein Binding Identical Protein Binding Transcription Coregulator Binding Enzyme Binding Negative Regulation Of Gene Expression, Epigenetic Chromatin Binding Transcription Corepressor Binding Ubiquitin Protein Ligase Binding SUMO Transferase Activity Cytosol Regulation Of Multicellular Organismal Process Epigenetic Regulation Of Gene Expression Transcription Regulator Complex Negative Regulation Of Multicellular Organismal Process Transcription Corepressor Activity Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Protein Deacetylation Rhythmic Process Positive Regulation Of Intracellular Estrogen Receptor Signaling Pathway
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