PHC2 and TRIM41

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		PHC2	TRIM41
Description		polyhomeotic homolog 2	tripartite motif containing 41
Image		No pdb structure
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm PcG Protein Complex PRC1 Complex	Fibrillar Center Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Zinc Ion Binding Histone Binding Identical Protein Binding Metal Ion Binding	Protein Binding Zinc Ion Binding Transferase Activity Identical Protein Binding Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Spermatogenesis Negative Regulation Of DNA-templated Transcription	Protein Monoubiquitination Positive Regulation Of Signal Transduction Protein Ubiquitination Innate Immune Response Defense Response To Virus Positive Regulation Of Type I Interferon-mediated Signaling Pathway Cellular Response To Lipopolysaccharide Cellular Response To Muramyl Dipeptide
Pathways		Oxidative Stress Induced Senescence SUMOylation of DNA damage response and repair proteins SUMOylation of transcription cofactors SUMOylation of chromatin organization proteins SUMOylation of RNA binding proteins SUMOylation of DNA methylation proteins RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN gene transcription Regulation of PTEN gene transcription	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Adventurousness ( 30643258) Appendicular lean mass ( 33097823) Blood urea nitrogen levels ( 29403010 31152163) General risk tolerance (MTAG) ( 30643258) Pancreas volume ( 34128465) Pulse pressure ( 30224653) Risk-taking tendency (4-domain principal component model) ( 30643258) Smoking status (ever vs never smokers) ( 30643258) Urinary albumin excretion ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189)	Liver enzyme levels (alkaline phosphatase) ( 33972514) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		78 interacting genes: AEN AFG3L2 AIRIM AP1M1 BMI1 BSDC1 BYSL CARD9 CRK CRKL DNMT1 DRG1 ENKD1 FAM124A FAM13C FAM161A FAM74A1 FAM74A4 FHL3 FOSB FXR1 FXR2 GFI1B GRB2 H3-4 HDAC7 KAT5 KBTBD7 KDM1A KIFC3 KLHDC7B KRT31 L3MBTL3 LMO1 LMO2 LMO3 MAB21L3 MAGEB6 MAPK14 MAPK6 MAPKAPK2 MCM2 MCRS1 MFAP1 MLLT6 MORF4L2 NCK1 PCGF3 PHC1 PLAGL2 PLK1 POLR2L PPP1R16B PRKAA1 PRPF3 PRPF31 RBM39 RNF2 RPL7 RWDD2B SCMH1 SDCBP SFMBT1 SIAH1 SMAD3 SPATC1L SSX2IP SYT16 TAB1 THAP7 TMEM70 TRIM41 TRIM55 TRIM63 ZBTB24 ZGPAT ZMAT2 ZNF417	144 interacting genes: AEN AKTIP ANKRD23 AP1M1 APP AQP1 BIVM BRAP BYSL C8orf33 CARD10 CCNL2 CEP44 CHD2 CSNK2A1 CSNK2A2 DDX41 DEPTOR DRC4 DVL3 EHHADH EZHIP FAM124A FAM161A FAM9A FLACC1 FRA10AC1 GPATCH2L IKBKG JRK KATNBL1 KIFC3 KRTAP10-8 KRTAP10-9 MAGEH1 MCRS1 MEOX1 MEOX2 MFAP1 MID2 MOBP MORF4L1 MORF4L2 MPP3 NCK2 NEDD4L NFE2L2 NOD2 PBX4 PHC2 PHF11 PHF7 PLAGL2 PRDM14 PRKCA PRKCB PRPF31 PTPN3 PUS7L RBAK RNPS1 SORBS3 SRPK2 STX11 SUV39H1 SYCE1 SYTL4 TBC1D26 TCEA2 TCEANC TLE5 TNNI1 TOP3B TP53 TRAIP TRIM17 TRIM26 TRIM4 TRIM52 TRIM55 TRIM63 UBE2D1 UBE2D2 UBE2I ZBTB24 ZBTB26 ZBTB38 ZBTB39 ZBTB48 ZBTB8A ZCCHC7 ZFP1 ZFP2 ZFP64 ZMAT5 ZNF121 ZNF134 ZNF138 ZNF165 ZNF2 ZNF219 ZNF24 ZNF250 ZNF251 ZNF26 ZNF263 ZNF264 ZNF266 ZNF275 ZNF286A ZNF319 ZNF329 ZNF343 ZNF398 ZNF408 ZNF417 ZNF439 ZNF460 ZNF473 ZNF48 ZNF490 ZNF497 ZNF526 ZNF552 ZNF564 ZNF575 ZNF587 ZNF629 ZNF648 ZNF653 ZNF655 ZNF670 ZNF691 ZNF696 ZNF71 ZNF773 ZNF780A ZNF784 ZNF792 ZNF835 ZNF837 ZSCAN16 ZSCAN21 ZSCAN26
Entrez ID		1912	90933
HPRD ID		10340	15558
Ensembl ID		ENSG00000134686	ENSG00000146063
Uniprot IDs		A0A0A0MSI2 A0A994J5J9 Q8IXK0	Q8WV44
PDB IDs			2EGM
Enriched GO Terms of Interacting Partners?		Nucleus Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin Organization Negative Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of RNA Metabolic Process Regulation Of DNA-templated Transcription Negative Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Negative Regulation Of RNA Biosynthetic Process PRC1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Binding Negative Regulation Of Metabolic Process Protein Binding Negative Regulation Of Macromolecule Biosynthetic Process Zinc Ion Binding Diapedesis Negative Regulation Of Biosynthetic Process PcG Protein Complex Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Chromatin Remodeling Identical Protein Binding Regulation Of Macromolecule Biosynthetic Process Regulation Of Rac Protein Signal Transduction Regulation Of Primary Metabolic Process Regulation Of Transcription By RNA Polymerase II Helper T Cell Diapedesis DNA-binding Transcription Factor Binding Response To Ionizing Radiation RING-like Zinc Finger Domain Binding Cerebellar Neuron Development Regulation Of Translation At Presynapse, Modulating Synaptic Transmission Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Regulation Of Protein Localization To Nucleus U2-type Precatalytic Spliceosome Heterochromatin Response To Muramyl Dipeptide Regulation Of Macromolecule Metabolic Process Histone H2AK119 Ubiquitin Ligase Activity Histone Binding Metal Ion Binding Regulation Of Intracellular Signal Transduction Regulation Of Metabolic Process Epigenetic Regulation Of Gene Expression Ephrin Receptor Binding Promoter-specific Chromatin Binding MLL1 Complex	Zinc Ion Binding Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process DNA Binding Nucleus RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Regulation Of Gene Expression Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Metal Ion Binding Regulation Of Metabolic Process DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Protein Binding DNA-binding Transcription Factor Activity Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Ubiquitin Protein Ligase Activity Negative Regulation Of DNA-templated Transcription Histone H3T6 Kinase Activity Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of RNA Metabolic Process Negative Regulation Of RNA Metabolic Process Sequence-specific Double-stranded DNA Binding Protein Kinase CK2 Complex Protein Ubiquitination Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Transcription By RNA Polymerase II Protein Kinase C Signaling Positive Regulation Of Nucleobase-containing Compound Metabolic Process Hematopoietic Stem Cell Differentiation Somite Specification
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