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PHC2 and PRKAA1
Number of citations of the paper that reports this interaction (PubMedID
25416956
)
56
Data Source:
BioGRID
(two hybrid)
PHC2
PRKAA1
Description
polyhomeotic homolog 2
protein kinase AMP-activated catalytic subunit alpha 1
Image
No pdb structure
GO Annotations
Cellular Component
Heterochromatin
Nucleus
Nucleoplasm
PcG Protein Complex
PRC1 Complex
Chromatin
Nucleus
Nucleoplasm
Cytoplasm
Cytosol
Cilium
Apical Plasma Membrane
Nuclear Speck
Axon
Dendrite
Nucleotide-activated Protein Kinase Complex
Protein-containing Complex
Ciliary Basal Body
Neuronal Cell Body
Molecular Function
DNA Binding
Chromatin Binding
Protein Binding
Zinc Ion Binding
Histone Binding
Identical Protein Binding
Metal Ion Binding
Nucleotide Binding
Chromatin Binding
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
AMP-activated Protein Kinase Activity
CAMP-dependent Protein Kinase Activity
Protein Binding
ATP Binding
Kinase Activity
Transferase Activity
Protein-containing Complex Binding
Metal Ion Binding
[hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity
Tau Protein Binding
Tau-protein Kinase Activity
Protein Serine Kinase Activity
Histone H2BS36 Kinase Activity
Biological Process
Spermatogenesis
Negative Regulation Of DNA-templated Transcription
Autophagosome Assembly
Response To Hypoxia
Cytoplasmic Translation
Negative Regulation Of T Cell Mediated Immune Response To Tumor Cell
Positive Regulation Of T Cell Mediated Immune Response To Tumor Cell
Glucose Metabolic Process
Chromatin Organization
Chromatin Remodeling
Lipid Metabolic Process
Fatty Acid Metabolic Process
Fatty Acid Biosynthetic Process
Phosphatidylethanolamine Biosynthetic Process
Phosphatidylcholine Biosynthetic Process
Steroid Biosynthetic Process
Cholesterol Biosynthetic Process
Autophagy
Lysosome Organization
Signal Transduction
Steroid Metabolic Process
Cholesterol Metabolic Process
Positive Regulation Of Cell Population Proliferation
Lipid Biosynthetic Process
Cellular Response To Starvation
Response To Xenobiotic Stimulus
Response To UV
Cold Acclimation
Response To Gamma Radiation
Positive Regulation Of Autophagy
Positive Regulation Of Gene Expression
Negative Regulation Of Gene Expression
Response To Activity
Wnt Signaling Pathway
Sterol Biosynthetic Process
Fatty Acid Oxidation
Response To Caffeine
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
Protein Destabilization
Cellular Response To Nutrient Levels
Negative Regulation Of TOR Signaling
Cellular Response To Stress
Cellular Response To Amino Acid Starvation
Cellular Response To Oxidative Stress
TORC1 Signaling
Cellular Response To Glucose Starvation
Response To Hydrogen Peroxide
Glucose Homeostasis
Regulation Of Circadian Rhythm
Negative Regulation Of Apoptotic Process
Regulation Of Vascular Permeability
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Response To Estrogen
Positive Regulation Of Cholesterol Biosynthetic Process
Positive Regulation Of Glycolytic Process
Positive Regulation Of DNA-templated Transcription
Negative Regulation Of Translational Initiation
Positive Regulation Of Translational Initiation
Negative Regulation Of Glucosylceramide Biosynthetic Process
Negative Regulation Of Insulin Receptor Signaling Pathway
Rhythmic Process
Positive Regulation Of Skeletal Muscle Tissue Development
Protein Stabilization
Negative Regulation Of T Cell Activation
Positive Regulation Of T Cell Activation
Negative Regulation Of Lipid Catabolic Process
Fatty Acid Homeostasis
Regulation Of Vesicle-mediated Transport
Protein Localization To Lysosome
Motor Behavior
CAMKK-AMPK Signaling Cascade
Regulation Of Stress Granule Assembly
Protein-containing Complex Assembly
Neuron Cellular Homeostasis
Cellular Response To Hydrogen Peroxide
Regulation Of Microtubule Cytoskeleton Organization
Cellular Response To Calcium Ion
Cellular Response To Glucose Stimulus
Cellular Response To Ethanol
Cellular Response To Prostaglandin E Stimulus
Cellular Response To Hypoxia
Cellular Response To Xenobiotic Stimulus
Protein K6-linked Ubiquitination
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Energy Homeostasis
Hepatocyte Apoptotic Process
Negative Regulation Of Protein Localization To Nucleus
Positive Regulation Of Mitochondrial Transcription
Positive Regulation Of Protein Localization
Negative Regulation Of Hepatocyte Apoptotic Process
Positive Regulation Of Protein Targeting To Mitochondrion
Positive Regulation Of Adipose Tissue Development
Negative Regulation Of TORC1 Signaling
Positive Regulation Of TORC1 Signaling
Negative Regulation Of Tubulin Deacetylation
Lipid Droplet Disassembly
Protein Localization To Lipid Droplet
Pathways
Oxidative Stress Induced Senescence
SUMOylation of DNA damage response and repair proteins
SUMOylation of transcription cofactors
SUMOylation of chromatin organization proteins
SUMOylation of RNA binding proteins
SUMOylation of DNA methylation proteins
RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known
Regulation of PTEN gene transcription
Regulation of PTEN gene transcription
Macroautophagy
Energy dependent regulation of mTOR by LKB1-AMPK
TP53 Regulates Metabolic Genes
Regulation of TP53 Activity through Phosphorylation
Activation of AMPK downstream of NMDARs
AMPK-induced ERAD and lysosome mediated degradation of PD-L1(CD274)
Drugs
Adenosine phosphate
Adenosine phosphate
ATP
Phenformin
Acetylsalicylic acid
Fostamatinib
Fostamatinib
Diseases
GWAS
Adventurousness (
30643258
)
Appendicular lean mass (
33097823
)
Blood urea nitrogen levels (
29403010
31152163
)
General risk tolerance (MTAG) (
30643258
)
Pancreas volume (
34128465
)
Pulse pressure (
30224653
)
Risk-taking tendency (4-domain principal component model) (
30643258
)
Smoking status (ever vs never smokers) (
30643258
)
Urinary albumin excretion (
30220432
)
Urinary albumin-to-creatinine ratio (
31630189
)
Cardia gastric cancer (
26129866
)
Gastric cancer (
22037551
26098866
26129866
31383772
)
Immature fraction of reticulocytes (
32888494
)
Mean corpuscular hemoglobin (
32888494
)
Mean corpuscular volume (
32888494
)
Non-cardia gastric cancer (
26129866
26701879
)
Interacting Genes
78 interacting genes:
AEN
AFG3L2
AIRIM
AP1M1
BMI1
BSDC1
BYSL
CARD9
CRK
CRKL
DNMT1
DRG1
ENKD1
FAM124A
FAM13C
FAM161A
FAM74A1
FAM74A4
FHL3
FOSB
FXR1
FXR2
GFI1B
GRB2
H3-4
HDAC7
KAT5
KBTBD7
KDM1A
KIFC3
KLHDC7B
KRT31
L3MBTL3
LMO1
LMO2
LMO3
MAB21L3
MAGEB6
MAPK14
MAPK6
MAPKAPK2
MCM2
MCRS1
MFAP1
MLLT6
MORF4L2
NCK1
PCGF3
PHC1
PLAGL2
PLK1
POLR2L
PPP1R16B
PRKAA1
PRPF3
PRPF31
RBM39
RNF2
RPL7
RWDD2B
SCMH1
SDCBP
SFMBT1
SIAH1
SMAD3
SPATC1L
SSX2IP
SYT16
TAB1
THAP7
TMEM70
TRIM41
TRIM55
TRIM63
ZBTB24
ZGPAT
ZMAT2
ZNF417
72 interacting genes:
ABI2
ACACA
AGAP2
ATM
BHLHE40
CAB39
CAMKK1
CDX4
CFTR
CHEK1
CRTC2
CTBP1
DVL2
EEF2K
EPM2A
FANCA
FNIP1
GATA1
GOLGA2
GRIK2
HDAC5
HMBOX1
HOMEZ
IKZF3
INO80E
KIF16B
KRT40
L3MBTL3
MAGEA3
MAGEA6
MDM4
MORC4
MTOR
MTUS2
PASK
PFKFB2
PHC2
PNMA5
PPM1A
PPM1E
PPM1F
PPP2CA
PRKAB1
PRKAB2
PRKAG1
PRKAG3
PSMD11
RACK1
RAD54B
RAF1
RBPMS
RFX6
RIMBP3
ROPN1
RPTOR
SLC31A1
SRPK2
SSX2IP
THAP1
TLE5
TOMM34
TRIM27
TRIM28
TRIP6
TSC2
TSC22D4
TXNIP
UBXN11
ULK1
VPS37B
VPS52
ZBED1
Entrez ID
1912
5562
HPRD ID
10340
04115
Ensembl ID
ENSG00000134686
ENSG00000132356
Uniprot IDs
A0A0A0MSI2
A0A994J5J9
Q8IXK0
Q13131
PDB IDs
4RED
4RER
4REW
5EZV
6C9F
6C9G
6C9H
6C9J
7JHG
7JHH
7JIJ
7M74
Enriched GO Terms of Interacting Partners
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Nucleus
Nucleoplasm
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Chromatin Organization
Negative Regulation Of RNA Metabolic Process
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Regulation Of DNA-templated Transcription
Negative Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Negative Regulation Of RNA Biosynthetic Process
PRC1 Complex
Negative Regulation Of Macromolecule Metabolic Process
Chromatin Binding
Negative Regulation Of Metabolic Process
Protein Binding
Negative Regulation Of Macromolecule Biosynthetic Process
Zinc Ion Binding
Diapedesis
Negative Regulation Of Biosynthetic Process
PcG Protein Complex
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Chromatin Remodeling
Identical Protein Binding
Regulation Of Macromolecule Biosynthetic Process
Regulation Of Rac Protein Signal Transduction
Regulation Of Primary Metabolic Process
Regulation Of Transcription By RNA Polymerase II
Helper T Cell Diapedesis
DNA-binding Transcription Factor Binding
Response To Ionizing Radiation
RING-like Zinc Finger Domain Binding
Cerebellar Neuron Development
Regulation Of Translation At Presynapse, Modulating Synaptic Transmission
Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling
Regulation Of Protein Localization To Nucleus
U2-type Precatalytic Spliceosome
Heterochromatin
Response To Muramyl Dipeptide
Regulation Of Macromolecule Metabolic Process
Histone H2AK119 Ubiquitin Ligase Activity
Histone Binding
Metal Ion Binding
Regulation Of Intracellular Signal Transduction
Regulation Of Metabolic Process
Epigenetic Regulation Of Gene Expression
Ephrin Receptor Binding
Promoter-specific Chromatin Binding
MLL1 Complex
Nucleus
Regulation Of Primary Metabolic Process
Negative Regulation Of Metabolic Process
Negative Regulation Of Macromolecule Biosynthetic Process
Regulation Of Metabolic Process
Negative Regulation Of Biosynthetic Process
Negative Regulation Of Macromolecule Metabolic Process
Identical Protein Binding
Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of Macromolecule Biosynthetic Process
Regulation Of DNA-templated Transcription
Regulation Of RNA Biosynthetic Process
Phosphorylation
Regulation Of Macromolecule Metabolic Process
Nucleotide-activated Protein Kinase Complex
Negative Regulation Of Nucleobase-containing Compound Metabolic Process
Regulation Of RNA Metabolic Process
Negative Regulation Of DNA-templated Transcription
Negative Regulation Of RNA Biosynthetic Process
Negative Regulation Of Autophagy
Negative Regulation Of Transcription By RNA Polymerase II
Regulation Of Gene Expression
Nucleoplasm
Cytosol
Positive Regulation Of Metabolic Process
Negative Regulation Of RNA Metabolic Process
Cellular Response To Nutrient Levels
AMP-activated Protein Kinase Activity
Protein Phosphorylation
Cytoplasm
Regulation Of Glycolytic Process
Regulation Of Transcription By RNA Polymerase II
Regulation Of Autophagy
Negative Regulation Of Catabolic Process
Response To Starvation
Protein Binding
Protein Modification Process
Regulation Of Carbohydrate Catabolic Process
Positive Regulation Of Biosynthetic Process
Regulation Of ATP Metabolic Process
Regulation Of Generation Of Precursor Metabolites And Energy
Protein Metabolic Process
Regulation Of Purine Nucleotide Metabolic Process
Regulation Of Cell Cycle
Cation Binding
Response To Nutrient Levels
Protein Serine/threonine Phosphatase Activity
Negative Regulation Of TOR Signaling
Positive Regulation Of DNA-templated Transcription
Positive Regulation Of RNA Biosynthetic Process
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Tagcloud (Intersection)
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