MALAT1 and KHSRP

Number of citations: 49 (PubMedID 37156809)
Data Source: BioGRID (unspecified method, affinity chromatography technology)

		MALAT1	KHSRP
Name		metastasis associated lung adenocarcinoma transcript 1	KH-type splicing regulatory protein
Structure		No pdb structure
GO Annotations	Cellular Component	None	Exosome (RNase Complex) Nucleus Nucleoplasm Cytoplasm Cytosol Membrane
	Molecular Function	None	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding Protein Binding MRNA 3'-UTR AU-rich Region Binding Protein Folding Chaperone
	Biological Process	Positive Regulation Of Cell Motility	RNA Splicing, Via Transesterification Reactions Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II MRNA Processing Protein Folding RNA Splicing MiRNA Metabolic Process Negative Regulation Of Low-density Lipoprotein Particle Clearance Regulation Of MRNA Stability Negative Regulation Of Nitric Oxide Biosynthetic Process MRNA Transport Positive Regulation Of MRNA Catabolic Process 3'-UTR-mediated MRNA Destabilization Cellular Response To Cytokine Stimulus
Pathways		None	ATF4 activates genes in response to endoplasmic reticulum stress KSRP (KHSRP) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA
Drugs		None	Resveratrol Artenimol
GWAS		Acne (severe) ( 24927181 ) Glaucoma ( 31959993 ) Hip circumference adjusted for BMI ( 25673412 34021172 )	No GWAS studies recorded
Novel Interactors		None recorded	2 novel interactors: GCC1 TNFSF9
Interacting Genes		6 interacting genes: CCAR2 FBXW7 HMGB1 KHSRP LIG3 PARP1	17 interacting genes: A1CF APBB1 BACE1 CEBPA EXOSC2 EXOSC3 GADD45A GSK3B HNRNPA1 HNRNPH1 MALAT1 NRON PARN PTBP2 SLC25A21-AS1 STK3 UBE2I
Entrez ID		378938	8570
HPRD ID		Not available	10350
Ensembl ID		ENSG00000251562	ENSG00000088247
Uniprot IDs		Not available	M0R0C6 Q92945
PDB IDs		Not available	2HH2 2HH3 2JVZ 2OPU 2OPV 4B8T
GO Terms Enriched among Interactors		DNA Damage Response Nucleic Acid Metabolic Process Mitochondrial DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Circadian Rhythm Mitochondrial DNA Metabolic Process Positive Regulation Of Programmed Cell Death Response To UV DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress V(D)J Recombination Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Double-strand Break Repair DNA Metabolic Process DNA Recombination Mitochondrion Organization Base-excision Repair Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Light Stimulus Nucleoplasm Chromosome Organization Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Damaged DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Radiation NAD+-protein-tyrosine ADP-ribosyltransferase Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Mitochondrial DNA Replication DNA Ligase III-XRCC1 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Organelle Organization	Poly(A)-dependent SnoRNA 3'-end Processing Sno(s)RNA Metabolic Process MRNA Metabolic Process 3'-5'-RNA Exonuclease Activity CUT Catabolic Process Negative Regulation Of Macromolecule Metabolic Process RNA Processing Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRAMP-dependent TRNA Surveillance Pathway TRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process U4 SnRNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process RRNA 3'-end Processing Nucleolar Exosome (RNase Complex) RNA Metabolic Process TRNA Decay RNA 3'-end Processing Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity RNA Binding Nucleic Acid Metabolic Process Nuclear Exosome (RNase Complex) Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process Regulation Of Gene Expression Positive Regulation Of Apoptotic Process SnRNA 3'-end Processing Positive Regulation Of Programmed Cell Death Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Telomere Maintenance Via Telomerase Macromolecule Metabolic Process Nucleic Acid Binding MRNA Catabolic Process Positive Regulation Of Telomere Maintenance Via Telomere Lengthening SnRNA Processing Nuclear RNA Surveillance Nucleobase-containing Compound Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process RNA Surveillance Presynaptic Modulation Of Chemical Synaptic Transmission RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Negative Regulation Of Peptidyl-serine Phosphorylation Of STAT Protein Regulation Of Microtubule Anchoring At Centrosome Spliceosomal Complex Regulation Of Telomere Maintenance Via Telomerase Regulation Of RNA Splicing PriRNA 3'-end Processing