MALAT1 and LIG3

Number of citations of the paper that reports this interaction (PubMedID 33030583)
0

Data Source:
BioGRID (unspecified method)

		MALAT1	LIG3
Description		metastasis associated lung adenocarcinoma transcript 1	DNA ligase 3
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Mitochondrion Mitochondrial Matrix DNA Ligase III-XRCC1 Complex
	Molecular Function		Nucleotide Binding DNA Binding DNA Ligase Activity DNA Ligase (ATP) Activity Protein Binding ATP Binding Zinc Ion Binding Ligase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Cell Motility	Double-strand Break Repair Via Homologous Recombination DNA Replication Lagging Strand Elongation DNA Repair Base-excision Repair Base-excision Repair, Gap-filling Double-strand Break Repair DNA Recombination DNA Damage Response Mitochondrion Organization V(D)J Recombination Mitochondrial DNA Repair Negative Regulation Of DNA Metabolic Process Cell Division DNA Biosynthetic Process Negative Regulation Of Mitochondrial DNA Replication Double-strand Break Repair Via Alternative Nonhomologous End Joining
Pathways			Resolution of AP sites via the single-nucleotide replacement pathway APEX1-Independent Resolution of AP Sites via the Single Nucleotide Replacement Pathway HDR through MMEJ (alt-NHEJ) Gap-filling DNA repair synthesis and ligation in GG-NER Gap-filling DNA repair synthesis and ligation in TC-NER
Drugs			Bleomycin
Diseases
GWAS		Acne (severe) ( 24927181) Glaucoma ( 31959993) Hip circumference adjusted for BMI ( 25673412 34021172)	Acute post-radiotherapy pain in breast cancer ( 31196165) Electrocardiographic traits (multivariate) ( 32602732) Night sleep phenotypes ( 27126917) Nonobstructive coronary artery disease ( 26534935) Pulse pressure ( 30224653) QT interval ( 19305408 24952745 29874175 30679814) TPE interval (resting) ( 32386560)
Interacting Genes		6 interacting genes: CCAR2 FBXW7 HMGB1 KHSRP LIG3 PARP1	8 interacting genes: APP JTB MALAT1 PARP1 TDP1 XRCC1 XRCC5 XRCC6
Entrez ID		378938	3980
HPRD ID			02966
Ensembl ID		ENSG00000251562	ENSG00000005156
Uniprot IDs			B7Z6I3 P49916
PDB IDs			1IMO 1IN1 1UW0 3L2P 3PC7 3PC8 3QVG 6WH1
Enriched GO Terms of Interacting Partners?		DNA Damage Response Nucleic Acid Metabolic Process Mitochondrial DNA Repair Nucleobase-containing Compound Metabolic Process Negative Regulation Of Metabolic Process Regulation Of Circadian Rhythm Mitochondrial DNA Metabolic Process Positive Regulation Of Programmed Cell Death Response To UV DNA Repair Negative Regulation Of Macromolecule Metabolic Process Regulation Of Cellular Response To Stress V(D)J Recombination Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Intrinsic Apoptotic Signaling Pathway Cellular Response To Stress Double-strand Break Repair DNA Metabolic Process DNA Recombination Mitochondrion Organization Base-excision Repair Regulation Of Oxidative Stress-induced Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Somatic Cell DNA Recombination Negative Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Response To Light Stimulus Nucleoplasm Chromosome Organization Double-strand Break Repair Via Nonhomologous End Joining Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Damaged DNA Binding Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Signaling Pathway NAD+-histone H3S10 Serine ADP-ribosyltransferase Activity NAD+-histone H2BS6 Serine ADP-ribosyltransferase Activity Negative Regulation Of Multicellular Organismal Process Positive Regulation Of Intracellular Signal Transduction NAD+-histone H2BE35 Glutamate ADP-ribosyltransferase Activity NAD+-protein-histidine ADP-ribosyltransferase Activity Response To Radiation NAD+-protein-tyrosine ADP-ribosyltransferase Activity Calcium-dependent Protein Kinase Regulator Activity Regulation Of Restriction Endodeoxyribonuclease Activity Positive Regulation Of Myeloid Progenitor Cell Differentiation Negative Regulation Of Mitochondrial DNA Replication DNA Ligase III-XRCC1 Complex Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Organelle Organization	Double-strand Break Repair Damaged DNA Binding Telomere Maintenance Telomere Organization DNA End Binding Ku70:Ku80 Complex Protein-DNA Complex Site Of DNA Damage Chromosome, Telomeric Region Regulation Of Base-excision Repair DNA Repair Response To Gamma Radiation Regulation Of Phosphorus Metabolic Process Double-strand Break Repair Via Nonhomologous End Joining DNA-dependent Protein Kinase Complex DNA Recombination DNA-dependent Protein Kinase-DNA Ligase 4 Complex 5'-deoxyribose-5-phosphate Lyase Activity Nonhomologous End Joining Complex DNA Metabolic Process Positive Regulation Of Phosphate Metabolic Process Nuclear Telomere Cap Complex Double-stranded Telomeric DNA Binding DNA Damage Response Chromosome Organization Single Strand Break Repair Regulation Of Telomere Maintenance Positive Regulation Of Protein Kinase Activity Double-stranded DNA Binding Negative Regulation Of DNA Metabolic Process Response To Radiation Positive Regulation Of Kinase Activity Regulation Of Innate Immune Response Recombinational Repair Response To Ionizing Radiation Cellular Response To Radiation Telomeric DNA Binding Regulation Of Catalytic Activity Cellular Response To Gamma Radiation ATP-dependent Activity, Acting On DNA Innate Immune Response Negative Regulation Of Telomere Maintenance DNA Helicase Activity Positive Regulation Of Protein Phosphorylation Regulation Of Protein Kinase Activity Chromosome Regulation Of Chromosome Organization Cellular Response To Nerve Growth Factor Stimulus Positive Regulation Of Phosphorylation Regulation Of Kinase Activity
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