NHLRC1 and EPM2A

Number of citations of the paper that reports this interaction (PMID 22578008)
1

Data Source:
BioGRID (pull down)

		NHLRC1	EPM2A
Gene Name		NHL repeat containing E3 ubiquitin protein ligase 1	epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Endoplasmic Reticulum Cytosol Perinuclear Region Of Cytoplasm	Nucleus Cytoplasm Endoplasmic Reticulum Cytosol Polysome Plasma Membrane
	Molecular Function	Ubiquitin-protein Transferase Activity Protein Binding Zinc Ion Binding Ligase Activity	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Protein Serine/threonine Phosphatase Activity Protein Tyrosine Phosphatase Activity Protein Binding Protein Tyrosine/serine/threonine Phosphatase Activity Carbohydrate Phosphatase Activity Starch Binding
	Biological Process	Protein Polyubiquitination Carbohydrate Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Autophagy Pathogenesis Positive Regulation Of Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Small Molecule Metabolic Process	Carbohydrate Metabolic Process Glycogen Metabolic Process Glycogen Biosynthetic Process Glucose Metabolic Process Protein Dephosphorylation Autophagy Nervous System Development Pathogenesis Peptidyl-tyrosine Dephosphorylation Small Molecule Metabolic Process Inositol Phosphate Dephosphorylation Habituation
Pathways		Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates	Glucose metabolism Glycogen synthesis Myoclonic epilepsy of Lafora Glycogen storage diseases Metabolism of carbohydrates
Drugs
Diseases
GWAS
Protein-Protein Interactions		9 interactors: AGL EPM2A NNAT PPP1R3C UBE2D1 UBE2D2 UBE2D3 UBE2E1 UBE2H	7 interactors: EPM2AIP1 NFU1 NHLRC1 PPP1R3D PRKAA1 PRKAA2 PRKAB2
Entrez ID		378884	7957
HPRD ID		06995	06345
Ensembl ID		ENSG00000187566	ENSG00000112425
Uniprot IDs		Q6VVB1	O95278
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein K48-linked Ubiquitination Protein Polyubiquitination Regulation Of Transcription From RNA Polymerase II Promoter In Response To Hypoxia Glycogen Biosynthetic Process Cellular Polysaccharide Biosynthetic Process Catabolic Process Polysaccharide Biosynthetic Process Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Proteolysis Involved In Cellular Protein Catabolic Process Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Cellular Protein Catabolic Process Protein Ubiquitination Regulation Of DNA-templated Transcription In Response To Stress Protein Modification By Small Protein Conjugation Glycogen Metabolic Process Protein Catabolic Process TRIF-dependent Toll-like Receptor Signaling Pathway MyD88-independent Toll-like Receptor Signaling Pathway Toll-like Receptor 3 Signaling Pathway Toll-like Receptor 4 Signaling Pathway Polysaccharide Metabolic Process Cellular Response To Hypoxia Cellular Response To Decreased Oxygen Levels Cellular Macromolecule Catabolic Process Toll-like Receptor Signaling Pathway Cellular Response To Oxygen Levels Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Energy Reserve Metabolic Process Activation Of Innate Immune Response Glucose Metabolic Process Carbohydrate Biosynthetic Process Cellular Protein Modification Process Protein K11-linked Ubiquitination Positive Regulation Of Innate Immune Response Pathogenesis Hexose Metabolic Process Cellular Carbohydrate Metabolic Process Mitotic Spindle Assembly Checkpoint Spindle Assembly Checkpoint Regulation Of Innate Immune Response Monosaccharide Metabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Mitotic Spindle Checkpoint Proteasomal Protein Catabolic Process Protein Monoubiquitination Negative Regulation Of Chromosome Segregation Proteolysis Spindle Checkpoint	Regulation Of Generation Of Precursor Metabolites And Energy Energy Reserve Metabolic Process Regulation Of Carbohydrate Metabolic Process Response To Insulin Energy Derivation By Oxidation Of Organic Compounds Carnitine Shuttle Generation Of Precursor Metabolites And Energy Carnitine Transmembrane Transport Carnitine Transport Regulation Of Energy Homeostasis Response To Peptide Hormone Positive Regulation Of Glycolytic Process Response To Peptide Fatty Acid Biosynthetic Process Regulation Of Lipid Biosynthetic Process Fatty Acid Homeostasis Cell Cycle Arrest Insulin Receptor Signaling Pathway Autophagy Quaternary Ammonium Group Transport Histone-serine Phosphorylation Oxidation-reduction Process Cellular Response To Glucose Starvation Cellular Response To Insulin Stimulus Regulation Of Glycolytic Process Regulation Of Glycogen Biosynthetic Process Negative Regulation Of TOR Signaling Regulation Of Fatty Acid Biosynthetic Process Cholesterol Biosynthetic Process Positive Regulation Of Autophagy Response To Organonitrogen Compound Regulation Of Glycogen Metabolic Process Long-chain Fatty Acid Transport Histone Phosphorylation Ammonium Transmembrane Transport Sterol Biosynthetic Process Regulation Of Lipid Metabolic Process Cellular Response To Peptide Hormone Stimulus Anion Homeostasis Response To Hormone Fatty Acid Metabolic Process Cellular Response To Peptide Regulation Of TOR Signaling Glycogen Metabolic Process Fatty Acid Transport Ammonium Transport Negative Regulation Of Cell Cycle Polysaccharide Metabolic Process Cellular Response To Organonitrogen Compound Regulation Of Fatty Acid Metabolic Process
Tagcloud ?		accepted apparently asses ataxia autosomal bodies cerebral characterizing codifying cortex dysregulation epm2a epm2b gabaergic glycogen imply lafora laforin malin myoclonic myoclonus neurodegeneration neurodevelopment neurotrophins operate p75ntr recessive seizures want	arms autophago biogenesis branched chop defects disposal encode epilepsy epm2b glycogen hyperphosphorylated insoluble knock lafora laforin laforinmalin lamp1 lc3 lysosomal malin myoclonus overaccumulation proteasomal s6 slight speculate starvation ubiquitinated
Tagcloud (Difference) ?		accepted apparently asses ataxia autosomal bodies cerebral characterizing codifying cortex dysregulation gabaergic imply myoclonic neurodegeneration neurodevelopment neurotrophins operate p75ntr recessive seizures want	arms autophago biogenesis branched chop defects disposal encode epilepsy hyperphosphorylated insoluble knock laforinmalin lamp1 lc3 lysosomal overaccumulation proteasomal s6 slight speculate starvation ubiquitinated
Tagcloud (Intersection) ?		epm2a epm2b glycogen lafora laforin malin myoclonus