KCNJ11 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		KCNJ11	EXOSC8
Description		potassium inwardly rectifying channel subfamily J member 11	exosome component 8
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GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Inward Rectifying Potassium Channel Membrane T-tubule Protein-containing Complex Monoatomic Ion Channel Complex	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	Nucleotide Binding Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Action Potential Response To Hypoxia Response To Ischemia Ventricular Cardiac Muscle Tissue Development Glucose Metabolic Process Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Determination Of Adult Lifespan Response To Xenobiotic Stimulus Cellular Response To Nutrient Levels Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process CAMKK-AMPK Signaling Cascade Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Presynaptic Membrane Potential Response To Resveratrol Potassium Ion Import Across Plasma Membrane	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs		Glimepiride Ibutilide Verapamil Tolazamide Ritodrine Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM) Type II diabetes mellitus
GWAS		Body mass index ( 29273807 28892062 25673413 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 30578418 27618448) Social communication problems ( 24564958) Systolic blood pressure ( 30578418 27618448) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 30718926 31118516 17463246 30297969 30054458 32499647 29632382 29358691 28869590 24509480 22885922 19056611 18372903 17463249 17463248) Type 2 diabetes (adjusted for BMI) ( 29632382)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA	112 interacting genes: AEN ANKHD1 ATF2 C22orf39 CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36
Entrez ID		3767	11340
HPRD ID		09022	09351
Ensembl ID		ENSG00000187486	ENSG00000120699
Uniprot IDs		A0A804HHV7 B2RC52 Q14654	Q96B26
PDB IDs		6C3O 6C3P 7S5T 7S5X 7S5Y 7S5Z 7S60 7S61	2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Potassium Ion-transporting ATPase Complex Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Glutamate Secretion, Neurotransmission Import Into Cell Regulation Of Potassium Ion Transport Sarcolemma Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Glutamate Secretion Transmembrane Transporter Binding Membrane Repolarization During Cardiac Muscle Cell Action Potential Circulatory System Development Membrane Repolarization During Action Potential Inward Rectifier Potassium Channel Activity Regulation Of System Process Metal Ion Transport Coronary Vasculature Development Regulation Of Heart Contraction Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization Response To ATP L-glutamate Import Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Neurotransmitter Secretion Fibroblast Proliferation ABC-type Transporter Activity Vascular Process In Circulatory System Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Acidic Amino Acid Transport Vasodilation Heart Morphogenesis Circulatory System Process Monoatomic Ion Transport	RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding
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