KCNJ11 and ABCC9

Number of citations of the paper that reports this interaction (PMID 10093054)
31

Data Source:
HPRD (in vitro)

		KCNJ11	ABCC9
Gene Name		potassium channel, inwardly rectifying subfamily J, member 11	ATP-binding cassette, sub-family C (CFTR/MRP), member 9
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber	Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Sarcomere Sarcolemma
	Molecular Function	Voltage-gated Potassium Channel Activity ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding	Transporter Activity Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity Potassium Channel Regulator Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Ion Channel Binding
	Biological Process	Response To Ischemia Glucose Metabolic Process Energy Reserve Metabolic Process Synaptic Transmission Potassium Ion Import Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Neurological System Process Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Positive Regulation Of Cation Channel Activity	Potassium Ion Transport Signal Transduction Synaptic Transmission Metabolic Process Potassium Ion Import Defense Response To Virus Transmembrane Transport
Pathways		Inwardly rectifying K+ channels Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels	Inwardly rectifying K+ channels ABC-family proteins mediated transport ATP sensitive Potassium channels Potassium Channels
Drugs		Glimepiride Ibutilide Verapamil Levosimendan Glyburide Diazoxide Thiamylal	Adenosine triphosphate Glyburide
Diseases
GWAS		Type 2 diabetes ( 18372903 17463246 17463248 17463249 19056611)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		6 interactors: ABCC8 ABCC9 AP2M1 KCNJ2 KCNJ8 LDHA	5 interactors: EEF1G KCNJ11 KCNJ8 LDHA STX1A
Entrez ID		3767	10060
HPRD ID		09022	03258
Ensembl ID		ENSG00000187486	ENSG00000069431
Uniprot IDs		B2RC52 Q14654	O60706
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Potassium Ion Transmembrane Transport Synaptic Transmission Potassium Ion Transport Cell-cell Signaling Monovalent Inorganic Cation Transport Response To External Stimulus Metal Ion Transport Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Cell Communication Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Transmembrane Transport Ion Transport Relaxation Of Skeletal Muscle Defense Response To Virus Response To Stimulus Response To Virus Regulation Of Resting Membrane Potential Transport Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Signaling Generation Of Precursor Metabolites And Energy Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Negative Regulation Of Protein Localization To Plasma Membrane Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Magnesium Ion Transport Regulation Of Defense Response To Virus By Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cellular Response To Stimulus Vasodilation Membrane Depolarization During Action Potential Response To PH Cardiac Muscle Cell Action Potential Clathrin-mediated Endocytosis Substantia Nigra Development Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transport	Potassium Ion Import Generation Of Precursor Metabolites And Energy Synaptic Transmission Energy Reserve Metabolic Process Cell-cell Signaling Potassium Ion Transmembrane Transport Regulation Of Insulin Secretion Potassium Ion Transport Regulation Of Peptide Hormone Secretion Response To Virus Regulation Of Hormone Secretion Regulation Of Membrane Potential Cellular Response To Nicotine Energy Derivation By Oxidation Of Organic Compounds Regulation Of Synaptic Vesicle Priming Synaptic Vesicle Docking Synaptic Vesicle Fusion To Presynaptic Membrane Oxidation-reduction Process Regulation Of Protein Secretion Regulation Of Ion Transmembrane Transport Response To Gravity Positive Regulation Of Neurotransmitter Secretion Ion Transport Response To External Stimulus Response To Stimulus Glutamate Secretion Response To ATP Regulation Of Ion Transport Regulation Of Protein Transport Positive Regulation Of Cation Channel Activity Regulation Of Secretion Vasodilation Response To Ischemia Positive Regulation Of Excitatory Postsynaptic Membrane Potential Regulation Of Synaptic Vesicle Exocytosis Monovalent Inorganic Cation Transport Response To PH Regulation Of Establishment Of Protein Localization Response To Testosterone Substantia Nigra Development Response To Nicotine Cellular Response To Alkaloid Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Response To Other Organism Regulation Of Synaptic Vesicle Transport Positive Regulation Of Membrane Potential Positive Regulation Of Transport Negative Regulation Of Peptide Secretion Response To Biotic Stimulus
Tagcloud ?		5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1	annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide
Tagcloud (Difference) ?		5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1	annually arid1a causing chd4 comprehensively deadliest deaths disruption endometrial enriched ep300 etiology exome fbxw7 frequencies grouping implicating ligase map3k4 mutated mutational remodeling resequenced serous sixth somatic spop tspyl2 worldwide
Tagcloud (Intersection) ?