KCNJ11 and ABCC9

Number of citations of the paper that reports this interaction (PubMedID 10093054)
0

Data Source:
HPRD (in vitro)

		KCNJ11	ABCC9
Description		potassium inwardly rectifying channel subfamily J member 11	ATP binding cassette subfamily C member 9
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Inward Rectifying Potassium Channel Membrane T-tubule Protein-containing Complex Monoatomic Ion Channel Complex	Cytoplasm Mitochondrion Plasma Membrane Inward Rectifying Potassium Channel Membrane Sarcomere Potassium Ion-transporting ATPase Complex Protein-containing Complex Sarcolemma
	Molecular Function	Nucleotide Binding Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Nucleotide Binding Potassium Channel Activity ATP Binding Sulfonylurea Receptor Activity ATP-activated Inward Rectifier Potassium Channel Activity Potassium Channel Regulator Activity ATP Hydrolysis Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Transmembrane Transporter Binding Protein-containing Complex Binding Potassium Channel Activator Activity ABC-type Transporter Activity
	Biological Process	Action Potential Response To Hypoxia Response To Ischemia Ventricular Cardiac Muscle Tissue Development Glucose Metabolic Process Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Determination Of Adult Lifespan Response To Xenobiotic Stimulus Cellular Response To Nutrient Levels Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process CAMKK-AMPK Signaling Cascade Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Presynaptic Membrane Potential Response To Resveratrol Potassium Ion Import Across Plasma Membrane	MAPK Cascade Action Potential Blood Vessel Development Response To Hypoxia Heart Morphogenesis Vascular Process In Circulatory System Regulation Of Transcription By RNA Polymerase II Potassium Ion Transport Response To Stress Mitochondrion Organization Heart Development Skeletal Muscle Tissue Development Blood Circulation Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Response To Activity Fatty Acid Oxidation Response To ATP Response To Potassium Ion Cellular Response To Potassium Ion Response To Decreased Oxygen Levels Vasodilation Regulation Of Membrane Potential Response To Hydrogen Peroxide Negative Regulation Of Apoptotic Process Response To Estrogen Cellular Respiration Negative Regulation Of Blood Pressure ATP Metabolic Process Fibroblast Proliferation Defense Response To Virus Transmembrane Transport Coronary Vasculature Development Cardiac Conduction Cellular Response To Chemical Stress Response To Oxygen Levels Cellular Response To Calcium Ion Cellular Response To ATP Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Circulatory System Development Oxygen Metabolic Process Cardiac Muscle Cell Contraction Blood Vessel Diameter Maintenance Monoatomic Cation Transmembrane Transport Monoatomic Anion Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Across Blood-brain Barrier Regulation Of Potassium Ion Transmembrane Transport Response To Peptide Reactive Oxygen Species Biosynthetic Process Response To Hydrogen Sulfide Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias	ATP sensitive Potassium channels ABC-family proteins mediated transport Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome
Drugs		Glimepiride Ibutilide Verapamil Tolazamide Ritodrine Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole	ATP Glyburide Nicorandil
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM) Type II diabetes mellitus	Atrial fibrillation
GWAS		Body mass index ( 29273807 28892062 25673413 26426971) Circulating leptin levels or type 2 diabetes ( 32341051) Mean arterial pressure ( 27618448) Medication use (drugs used in diabetes) ( 31015401) Pulse pressure ( 30578418 27618448) Social communication problems ( 24564958) Systolic blood pressure ( 30578418 27618448) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Type 2 diabetes ( 30718926 31118516 17463246 30297969 30054458 32499647 29632382 29358691 28869590 24509480 22885922 19056611 18372903 17463249 17463248) Type 2 diabetes (adjusted for BMI) ( 29632382)	Appendicular lean mass ( 33097823) Birth weight ( 27680694) Gout ( 22179738) Hippocampal sclerosis of aging ( 24770881) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Obesity-related traits ( 23251661) Offspring birth weight ( 31043758) Pulse pressure ( 30224653 30578418)
Interacting Genes		7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA	6 interacting genes: EEF1G HSPB2 KCNJ11 KCNJ8 LDHA STX1A
Entrez ID		3767	10060
HPRD ID		09022	03258
Ensembl ID		ENSG00000187486	ENSG00000069431
Uniprot IDs		A0A804HHV7 B2RC52 Q14654	O60706
PDB IDs		6C3O 6C3P 7S5T 7S5X 7S5Y 7S5Z 7S60 7S61
Enriched GO Terms of Interacting Partners?		Potassium Ion-transporting ATPase Complex Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Glutamate Secretion, Neurotransmission Import Into Cell Regulation Of Potassium Ion Transport Sarcolemma Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Glutamate Secretion Transmembrane Transporter Binding Membrane Repolarization During Cardiac Muscle Cell Action Potential Circulatory System Development Membrane Repolarization During Action Potential Inward Rectifier Potassium Channel Activity Regulation Of System Process Metal Ion Transport Coronary Vasculature Development Regulation Of Heart Contraction Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization Response To ATP L-glutamate Import Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Neurotransmitter Secretion Fibroblast Proliferation ABC-type Transporter Activity Vascular Process In Circulatory System Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Acidic Amino Acid Transport Vasodilation Heart Morphogenesis Circulatory System Process Monoatomic Ion Transport	Inward Rectifying Potassium Channel Response To Resveratrol ATP-activated Inward Rectifier Potassium Channel Activity CAMKK-AMPK Signaling Cascade Response To Stilbenoid Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ventricular Cardiac Muscle Tissue Development Inward Rectifier Potassium Channel Activity Regulation Of Presynaptic Membrane Potential Presynaptic Active Zone Membrane Response To ATP Determination Of Adult Lifespan Potassium Ion Import Across Plasma Membrane Response To Ischemia Cardiac Muscle Tissue Development Atrioventricular Node Cell Differentiation Myosin Head/neck Binding Voltage-gated Potassium Channel Complex Regulation Of Membrane Potential Inorganic Cation Import Across Plasma Membrane Neurotransmitter Transport Protein Localization To Extracellular Region Potassium Ion-transporting ATPase Complex Synaptic Assembly At Neuromuscular Junction Striated Muscle Tissue Development Cardiac Pacemaker Cell Differentiation Action Potential Establishment Of Protein Localization To Extracellular Region Protein Secretion Sulfonylurea Receptor Binding Monoatomic Ion Channel Complex Glutamate Secretion, Neurotransmission Glucose Metabolic Process Lactate Dehydrogenase Activity Glucose Catabolic Process To Lactate Via Pyruvate Asymmetric Neuroblast Division Positive Regulation Of Norepinephrine Secretion Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin II Complex Transmembrane Transporter Binding Somatic Muscle Development Import Across Plasma Membrane Potassium Ion Transmembrane Transport Import Into Cell Response To Purine-containing Compound Muscle Tissue Development L-lactate Dehydrogenase (NAD+) Activity Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Synaptobrevin 2-SNAP-25-syntaxin-1a Complex Calcium-mediated Signaling
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