KCNJ11 and KCNJ8

Number of citations: 37 (PubMedID 11136227)
Data Source: HPRD (in vivo, in vitro)

		KCNJ11	KCNJ8
Name		potassium inwardly rectifying channel subfamily J member 11	potassium inwardly rectifying channel subfamily J member 8
Structure			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Plasma Membrane Inward Rectifying Potassium Channel Membrane T-tubule Protein-containing Complex Monoatomic Ion Channel Complex	Plasma Membrane Voltage-gated Potassium Channel Complex Inward Rectifying Potassium Channel Membrane Myofibril Potassium Ion-transporting ATPase Complex Protein-containing Complex Monoatomic Ion Channel Complex Sarcolemma Presynaptic Active Zone Membrane Presynapse Glutamatergic Synapse
	Molecular Function	Nucleotide Binding Inward Rectifier Potassium Channel Activity Voltage-gated Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Ankyrin Binding Potassium Ion Binding Transmembrane Transporter Binding Metal Ion Binding Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential	Inward Rectifier Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Voltage-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential Voltage-gated Potassium Channel Activity Involved In Ventricular Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Action Potential Response To Hypoxia Response To Ischemia Ventricular Cardiac Muscle Tissue Development Glucose Metabolic Process Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Determination Of Adult Lifespan Response To Xenobiotic Stimulus Cellular Response To Nutrient Levels Response To ATP Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Nervous System Process CAMKK-AMPK Signaling Cascade Potassium Ion Transmembrane Transport Inorganic Cation Transmembrane Transport Regulation Of Presynaptic Membrane Potential Response To Resveratrol Potassium Ion Import Across Plasma Membrane	Action Potential Blood Vessel Development Response To Hypoxia Microglial Cell Activation Kidney Development Vasculature Development Regulation Of Heart Rate Adaptive Immune Response Response To Ischemia Heart Morphogenesis Ventricular Cardiac Muscle Tissue Development Monoatomic Ion Transport Potassium Ion Transport Apoptotic Process Response To Stress Inflammatory Response Heart Development Regulation Of Blood Pressure Cell Population Proliferation Determination Of Adult Lifespan Protein Secretion Response To Xenobiotic Stimulus Gene Expression Fatty Acid Transport Transmission Of Nerve Impulse Establishment Of Cell Polarity Response To Lipopolysaccharide Response To Insulin Response To ATP Response To Cytokine Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Response To Endoplasmic Reticulum Stress P38MAPK Cascade Vasodilation Response To Exogenous DsRNA NLRP3 Inflammasome Complex Assembly Fat Cell Differentiation Fibroblast Proliferation Nervous System Process Neuromuscular Process Synaptic Assembly At Neuromuscular Junction Defense Response To Virus Cardiac Pacemaker Cell Differentiation Atrioventricular Node Cell Differentiation Coronary Vasculature Development Glutamate Secretion, Neurotransmission CAMKK-AMPK Signaling Cascade Calcium Ion Transmembrane Transport Potassium Ion Transmembrane Transport Circulatory System Development Inorganic Cation Transmembrane Transport Membrane Repolarization During Ventricular Cardiac Muscle Cell Action Potential Regulation Of Presynaptic Membrane Potential Reactive Gliosis Transport Across Blood-brain Barrier Response To Resveratrol Potassium Ion Import Across Plasma Membrane
Pathways		ATP sensitive Potassium channels ABC-family proteins mediated transport Regulation of insulin secretion Ion homeostasis Defective ABCC9 causes CMD10, ATFB12 and Cantu syndrome Defective ABCC8 can cause hypo- and hyper-glycemias	ATP sensitive Potassium channels
Drugs		Glimepiride Ibutilide Verapamil Tolazamide Ritodrine Levosimendan Glyburide Glyburide Diazoxide Thiamylal Yohimbine Butamben Isavuconazole	Ritodrine Phenformin Levosimendan Glyburide Thiamylal Gliquidone Glisoxepide Yohimbine Butamben
Diseases		Permanent neonatal diabetes mellitus (PNDM) Transient neonatal diabetes mellitus (TNDM) Type II diabetes mellitus	None
GWAS		Body mass index ( 29273807 28892062 25673413 26426971 ) Circulating leptin levels or type 2 diabetes ( 32341051 ) Mean arterial pressure ( 27618448 ) Medication use (drugs used in diabetes) ( 31015401 ) Pulse pressure ( 30578418 27618448 ) Social communication problems ( 24564958 ) Systolic blood pressure ( 30578418 27618448 ) Systolic blood pressure x alcohol consumption interaction (2df test) ( 29912962 ) Type 2 diabetes ( 30718926 31118516 17463246 30297969 30054458 32499647 29632382 29358691 28869590 24509480 22885922 19056611 18372903 17463249 17463248 ) Type 2 diabetes (adjusted for BMI) ( 29632382 )	Birth weight ( 31043758 )
Interacting Genes		7 interacting genes: ABCC8 ABCC9 AP2M1 EXOSC8 KCNJ2 KCNJ8 LDHA	7 interacting genes: ABCC8 ABCC9 EMD KCNJ11 KCNJ2 TMEM140 TMEM54
Entrez ID		3767	3764
HPRD ID		09022	02962
Ensembl ID		ENSG00000187486	ENSG00000121361
Uniprot IDs		A0A804HHV7 B2RC52 Q14654	Q15842
PDB IDs		6C3O 6C3P 7S5T 7S5X 7S5Y 7S5Z 7S60 7S61	Not available
GO Terms Enriched among Interactors		Potassium Ion-transporting ATPase Complex Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Glutamate Secretion, Neurotransmission Import Into Cell Regulation Of Potassium Ion Transport Sarcolemma Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Glutamate Secretion Transmembrane Transporter Binding Membrane Repolarization During Cardiac Muscle Cell Action Potential Circulatory System Development Membrane Repolarization During Action Potential Inward Rectifier Potassium Channel Activity Regulation Of System Process Metal Ion Transport Coronary Vasculature Development Regulation Of Heart Contraction Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Membrane Repolarization Response To ATP L-glutamate Import Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Regulation Of Blood Circulation Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Neurotransmitter Secretion Fibroblast Proliferation ABC-type Transporter Activity Vascular Process In Circulatory System Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Acidic Amino Acid Transport Vasodilation Heart Morphogenesis Circulatory System Process Monoatomic Ion Transport	Inward Rectifying Potassium Channel ATP-activated Inward Rectifier Potassium Channel Activity Potassium Ion Import Across Plasma Membrane ATPase-coupled Monoatomic Cation Transmembrane Transporter Activity Inorganic Cation Import Across Plasma Membrane Action Potential Sulfonylurea Receptor Activity Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Potassium Ion-transporting ATPase Complex Regulation Of Potassium Ion Transport Regulation Of Monoatomic Ion Transport Regulation Of Membrane Potential Transmembrane Transporter Binding Inward Rectifier Potassium Channel Activity Metal Ion Transport Import Into Cell Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Response To ATP System Process Positive Regulation Of Potassium Ion Transport Inorganic Ion Transmembrane Transport Regulation Of Transport Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Negative Regulation Of Insulin Secretion ABC-type Transporter Activity T-tubule Negative Regulation Of Peptide Secretion Regulation Of Monoatomic Ion Transmembrane Transport Cardiac Conduction Response To Xenobiotic Stimulus Monoatomic Ion Transport Regulation Of Metal Ion Transport Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Hormone Secretion TMEM240-body Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Negative Regulation Of Protein Secretion Positive Regulation Of Uterine Smooth Muscle Relaxation Negative Regulation Of Neuroblast Migration Potassium Channel Activity Regulation Of Protein Transport Transmembrane Transport Relaxation Of Skeletal Muscle Sarcolemma Regulation Of Establishment Of Protein Localization Regulation Of System Process