KCNJ11 and KCNJ8

Number of citations of the paper that reports this interaction (PMID 11136227)
28

Data Source:
HPRD (in vitro, in vivo)

		KCNJ11	KCNJ8
Gene Name		potassium channel, inwardly rectifying subfamily J, member 11	potassium channel, inwardly rectifying subfamily J, member 8
Image		No pdb structure	No pdb structure
Gene Ontology Annotations	Cellular Component	Nuclear Envelope Mitochondrion Endosome Endoplasmic Reticulum Cytosol Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Intercalated Disc T-tubule Axolemma Neuronal Cell Body Myelin Sheath Cell Body Fiber	Mitochondrion Plasma Membrane Voltage-gated Potassium Channel Complex ATP-sensitive Potassium Channel Complex Myofibril Sarcolemma
	Molecular Function	Voltage-gated Potassium Channel Activity ATP Binding Protein C-terminus Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Ankyrin Binding Potassium Ion Binding Heat Shock Protein Binding Ion Channel Binding	Inward Rectifier Potassium Channel Activity ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity G-protein Activated Inward Rectifier Potassium Channel Activity Sulfonylurea Receptor Binding
	Biological Process	Response To Ischemia Glucose Metabolic Process Energy Reserve Metabolic Process Synaptic Transmission Potassium Ion Import Response To Estradiol Response To ATP Response To Testosterone Regulation Of Ion Transmembrane Transport Regulation Of Membrane Potential Response To Drug Small Molecule Metabolic Process Negative Regulation Of Insulin Secretion Regulation Of Insulin Secretion Neurological System Process Cellular Response To Nicotine Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Potassium Ion Transmembrane Transport Positive Regulation Of Cation Channel Activity	Kidney Development Potassium Ion Transport Synaptic Transmission Heart Development Response To PH Potassium Ion Import Response To Lipopolysaccharide Regulation Of Ion Transmembrane Transport Vasodilation Response To Exogenous DsRNA Defense Response To Virus
Pathways		Inwardly rectifying K+ channels Integration of energy metabolism ATP sensitive Potassium channels Regulation of insulin secretion Potassium Channels	Inwardly rectifying K+ channels ATP sensitive Potassium channels Potassium Channels
Drugs		Glimepiride Ibutilide Verapamil Levosimendan Glyburide Diazoxide Thiamylal
Diseases
GWAS		Type 2 diabetes ( 18372903 17463246 17463248 17463249 19056611)
Protein-Protein Interactions		6 interactors: ABCC8 ABCC9 AP2M1 KCNJ2 KCNJ8 LDHA	4 interactors: ABCC8 ABCC9 KCNJ11 KCNJ2
Entrez ID		3767	3764
HPRD ID		09022	02962
Ensembl ID		ENSG00000187486	ENSG00000121361
Uniprot IDs		B2RC52 Q14654	Q15842
PDB IDs
Enriched GO Terms of Interacting Partners?		Potassium Ion Import Potassium Ion Transmembrane Transport Synaptic Transmission Potassium Ion Transport Cell-cell Signaling Monovalent Inorganic Cation Transport Response To External Stimulus Metal Ion Transport Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Cell Communication Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Transmembrane Transport Ion Transport Relaxation Of Skeletal Muscle Defense Response To Virus Response To Stimulus Response To Virus Regulation Of Resting Membrane Potential Transport Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Signaling Generation Of Precursor Metabolites And Energy Positive Regulation Of Potassium Ion Transmembrane Transport Regulation Of Ion Transmembrane Transport Negative Regulation Of Protein Localization To Plasma Membrane Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Magnesium Ion Transport Regulation Of Defense Response To Virus By Virus Cardiac Muscle Cell Action Potential Involved In Contraction Positive Regulation Of Potassium Ion Transport Cellular Response To Stimulus Vasodilation Membrane Depolarization During Action Potential Response To PH Cardiac Muscle Cell Action Potential Clathrin-mediated Endocytosis Substantia Nigra Development Regulation Of Ion Transport Regulation Of Potassium Ion Transmembrane Transport	Potassium Ion Import Potassium Ion Transmembrane Transport Potassium Ion Transport Synaptic Transmission Monovalent Inorganic Cation Transport Metal Ion Transport Cell-cell Signaling Cation Transmembrane Transport Cation Transport Ion Transmembrane Transport Transmembrane Transport Ion Transport Positive Regulation Of Ion Transmembrane Transport Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Energy Reserve Metabolic Process Relaxation Of Skeletal Muscle Positive Regulation Of Ion Transport Regulation Of Insulin Secretion Regulation Of Peptide Hormone Secretion Regulation Of Hormone Secretion Regulation Of Membrane Potential Energy Derivation By Oxidation Of Organic Compounds Cellular Response To Nicotine Regulation Of Resting Membrane Potential Cellular Potassium Ion Homeostasis Regulation Of Skeletal Muscle Contraction Regulation Of Protein Secretion Membrane Repolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Action Potential Generation Of Precursor Metabolites And Energy Regulation Of Ion Transmembrane Transport Transport Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization Relaxation Of Cardiac Muscle Potassium Ion Homeostasis Positive Regulation Of Potassium Ion Transmembrane Transport Cellular Chemical Homeostasis Signaling Cell Communication Relaxation Of Muscle Regulation Of Membrane Repolarization Regulation Of Heart Rate By Cardiac Conduction Regulation Of Ion Transport Regulation Of Protein Transport Magnesium Ion Transport Regulation Of Secretion Response To ATP Regulation Of Establishment Of Protein Localization Cardiac Muscle Cell Action Potential Involved In Contraction
Tagcloud ?		5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Difference) ?		5x10 asian cdkal1 cdkn2a cgs discriminative gwas hhex hnf1b homa igf2bp2 jazf1 kcnq1 marginally modestly nominal notch2 nri reclassification relating replicated roc slc30a8 summing t2d tcf7l2 unweighted weighted wfs1	abundances agt ahr amongst aryl came car3 coherency constitutive contrasting creg1 ctsc e2f6 enpp1 gatm gstm4 halogenated hydrocarbon hydrocarbons inferences me1 overlap pdk1 physiologic profiled slc35a3 sqrdl transcriptomic xenobiotic
Tagcloud (Intersection) ?