SFT2D2 and HSD17B11

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFT2D2	HSD17B11
Description		SFT2 domain containing 2	hydroxysteroid 17-beta dehydrogenase 11
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Extracellular Exosome	Cytoplasm Endoplasmic Reticulum Lipid Droplet Cytosol
	Molecular Function	Protein Binding	Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Protein Binding Steroid Dehydrogenase Activity Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor
	Biological Process	Protein Transport Vesicle-mediated Transport	Lipid Metabolic Process Steroid Biosynthetic Process Estrogen Biosynthetic Process Androgen Catabolic Process
Pathways			Estrogen biosynthesis
Drugs			Aetiocholanolone
Diseases
GWAS		Alzheimer's disease ( 30636644) LDL cholesterol levels in HIV infection ( 33109212)	Appendicular lean mass ( 28724990) Bulimia nervosa ( 23568457) Lean body mass ( 28724990)
Interacting Genes		29 interacting genes: AQP6 ATP5PF BNIP2 CREB3 ELOVL4 GPR152 HIBADH HSD17B11 HSD17B13 IFNGR2 INPP5K LMNA MOB2 NDRG4 PBX3 PLIN2 PLIN3 REEP2 REEP4 SLC10A1 SLC10A6 SLC30A8 STOM TAS2R5 TCP11X2 TIMM44 TMEM143 TMEM14B TMEM51	54 interacting genes: ADIPOQ AGPAT3 AGPAT4 ANKRD46 BNIP1 CMTM3 CSGALNACT2 CYBC1 DGAT2L6 DHRSX EHHADH ERG28 FAM241B GIMAP1 GOLT1A HTATIP2 LRCH4 MS4A1 NEU1 ORMDL1 OTULINL PLP2 PRAF2 PTPN9 RASGRP3 RMDN2 RTP2 SEC22A SERPINE1 SFRP4 SFT2D2 SFXN3 SLC25A46 SLC30A8 SLC67A1 STRIT1 STX7 SYS1 TMEM120B TMEM128 TMEM14B TMEM167B TMEM203 TMEM242 TMEM42 TMEM65 TMX2 TPRG1 TTPA TVP23B UBC UNC50 VEZT YIPF6
Entrez ID		375035	51170
HPRD ID		14192	10881
Ensembl ID		ENSG00000213064	ENSG00000198189
Uniprot IDs		O95562	Q8NBQ5
PDB IDs			1YB1
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Triglyceride Storage Steroid Dehydrogenase Activity Lipid Droplet Bile Acid:sodium Symporter Activity Lipid Droplet Disassembly Endoplasmic Reticulum Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Membrane Positive Regulation Of Lipid Storage Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Nuclear Envelope Organization	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Golgi Membrane Protein Binding Endomembrane System SNAP Receptor Activity
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