SFT2D2 and TAS2R5

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		SFT2D2	TAS2R5
Description		SFT2 domain containing 2	taste 2 receptor member 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endomembrane System Membrane Extracellular Exosome	Plasma Membrane Membrane
	Molecular Function	Protein Binding	G Protein-coupled Receptor Activity Protein Binding Taste Receptor Activity Bitter Taste Receptor Activity
	Biological Process	Protein Transport Vesicle-mediated Transport	Detection Of Chemical Stimulus Involved In Sensory Perception Of Bitter Taste Signal Transduction G Protein-coupled Receptor Signaling Pathway Chemosensory Behavior Sensory Perception Of Taste
Pathways			G alpha (i) signalling events Class C/3 (Metabotropic glutamate/pheromone receptors) Sensory perception of sweet, bitter, and umami (glutamate) taste Sensory perception of sweet, bitter, and umami (glutamate) taste
Drugs
Diseases
GWAS		Alzheimer's disease ( 30636644) LDL cholesterol levels in HIV infection ( 33109212)	Anorexia nervosa ( 23568457) Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		29 interacting genes: AQP6 ATP5PF BNIP2 CREB3 ELOVL4 GPR152 HIBADH HSD17B11 HSD17B13 IFNGR2 INPP5K LMNA MOB2 NDRG4 PBX3 PLIN2 PLIN3 REEP2 REEP4 SLC10A1 SLC10A6 SLC30A8 STOM TAS2R5 TCP11X2 TIMM44 TMEM143 TMEM14B TMEM51	6 interacting genes: CCL4 RTP2 SFT2D2 SLC30A2 TMEM187 VAMP5
Entrez ID		375035	54429
HPRD ID		14192	05453
Ensembl ID		ENSG00000213064	ENSG00000127366
Uniprot IDs		O95562	A4D1U0 Q502V5 Q9NYW4
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Triglyceride Storage Steroid Dehydrogenase Activity Lipid Droplet Bile Acid:sodium Symporter Activity Lipid Droplet Disassembly Endoplasmic Reticulum Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Membrane Positive Regulation Of Lipid Storage Bile Acid And Bile Salt Transport Endoplasmic Reticulum Tubular Network Endoplasmic Reticulum Tubular Network Organization Nuclear Envelope Organization	Zinc Ion Import Into Zymogen Granule Zinc Ion Import Into Mitochondrion Zinc Ion Import Into Secretory Vesicle CCR1 Chemokine Receptor Binding Positive Regulation Of Natural Killer Cell Chemotaxis Zinc:proton Antiporter Activity Zinc Ion Import Into Lysosome Zinc Export Across Plasma Membrane Late Endosome Establishment Of Protein Localization To Membrane Olfactory Receptor Binding CCR5 Chemokine Receptor Binding Vacuolar Transmembrane Transport Zinc Ion Import Into Organelle Secretory Vesicle Endomembrane System
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