SNAP25 and OSBPL2

Number of citations of the paper that reports this interaction (PubMedID 32734583)
70

Data Source:
BioGRID (protein complementation assay, pull down)

		SNAP25	OSBPL2
Description		synaptosome associated protein 25	oxysterol binding protein like 2
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse	Cytoplasm Lipid Droplet Cytosol Plasma Membrane Cytoplasmic Side Of Plasma Membrane Membrane Perinuclear Endoplasmic Reticulum Presynaptic Active Zone Cytoplasmic Component Glutamatergic Synapse
	Molecular Function	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	Protein Binding Phosphatidylinositol-4,5-bisphosphate Binding Lipid Binding Phosphatidylinositol Transfer Activity Cholesterol Binding Sterol Transfer Activity Cholesterol Transfer Activity
	Biological Process	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis	Bile Acid Biosynthetic Process Lipid Transport Plasma Membrane Organization Regulation Of Synaptic Vesicle Priming Phospholipid Transport Cholesterol Transport Intracellular Cholesterol Transport Protein Homotetramerization Regulation Of Presynaptic Cytosolic Calcium Ion Concentration Intermembrane Lipid Transfer
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Synthesis of bile acids and bile salts
Drugs		Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS		Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)	Bipolar disorder ( 34002096) Estimated glomerular filtration rate ( 31152163) Femoral neck bone mineral density ( 29499414) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lumbar spine bone mineral density ( 29499414) Nicotine dependence symptom count ( 25555482) Prostate cancer ( 23535732) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494)
Interacting Genes		45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177	4 interacting genes: SNAP25 SNRPF UBC VAPB
Entrez ID		6616	9885
HPRD ID		02637	09473
Ensembl ID		ENSG00000132639	ENSG00000130703
Uniprot IDs		P60880	A0A2R8YDU7 B4DKJ8 E7ET92 Q9H1P3
PDB IDs		1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV	5ZM8
Enriched GO Terms of Interacting Partners?		SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport	Membrane Docking Organelle Localization By Membrane Tethering Vesicle Organization Ribbon Synapse Vesicle Dense Core Granule Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Fusion To Plasma Membrane Presynaptic Dense Core Vesicle Exocytosis Neuronal Dense Core Vesicle Exocytosis U4 SnRNP U7 SnRNP PICln-Sm Protein Complex 7-methylguanosine Cap Hypermethylation Endoplasmic Reticulum Localization FFAT Motif Binding Host-mediated Activation Of Viral Genome Replication COPII-coated Vesicle Budding Negative Regulation By Virus Of Viral Protein Levels In Host Cell IRE1-mediated Unfolded Protein Response Endoplasmic Reticulum-plasma Membrane Tethering Host-mediated Perturbation Of Viral Genome Replication Host-mediated Perturbation Of Viral RNA Genome Replication Synaptic Vesicle Docking Somatodendritic Compartment Synaptic Vesicle Membrane Organization BLOC-1 Complex Synaptic Vesicle Priming SMN-Sm Protein Complex Small Nuclear Ribonucleoprotein Complex Methylosome Protein Tag Activity Suppression Of Viral Release By Host Endoplasmic Reticulum Membrane Organization Host-mediated Suppression Of Viral Genome Replication Organelle Localization Syntaxin-1 Binding U1 SnRNP Secretory Granule Localization U5 SnRNP U2-type Prespliceosome Assembly U12-type Spliceosomal Complex Glutamatergic Synapse Neurotransmitter Uptake U2-type Spliceosomal Complex U2-type Catalytic Step 2 Spliceosome U2 SnRNP Viral Release From Host Cell
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