SNAP25 and OSBPL10

Number of citations of the paper that reports this interaction (PubMedID 32734583)
70

Data Source:
BioGRID (protein complementation assay)

		SNAP25	OSBPL10
Description		synaptosome associated protein 25	oxysterol binding protein like 10
Image			No pdb structure
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse	Cytoplasm Cytosol Cytoskeleton Membrane
	Molecular Function	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	Phosphatidylserine Binding Lipid Transporter Activity Protein Binding Phospholipid Transporter Activity Lipid Binding Cholesterol Binding
	Biological Process	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis	Lipid Metabolic Process Lipid Transport Phospholipid Transport Phosphatidylserine Acyl-chain Remodeling
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Acyl chain remodelling of PS
Drugs		Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS		Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)	Diabetic retinopathy in type 2 diabetes ( 33607655) Periodontal disease-related phenotype (Socransky) ( 24347629) Peripheral artery disease ( 20610895) Triglyceride levels x long total sleep time interaction (2df test) ( 31719535)
Interacting Genes		45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177	2 interacting genes: IKBKG SNAP25
Entrez ID		6616	114884
HPRD ID		02637	09480
Ensembl ID		ENSG00000132639	ENSG00000144645
Uniprot IDs		P60880	Q9BXB5 Q9NX98
PDB IDs		1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV
Enriched GO Terms of Interacting Partners?		SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport	Vesicle Localization Establishment Of Vesicle Localization Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Establishment Of Organelle Localization Presynaptic Dense Core Vesicle Exocytosis Linear Polyubiquitin Binding Organelle Localization Ribbon Synapse Neuronal Dense Core Vesicle Exocytosis IkappaB Kinase Complex Synaptic Vesicle Docking Dense Core Granule Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Fusion To Plasma Membrane Transferrin Receptor Binding Anoikis Somatodendritic Compartment Synaptic Vesicle Membrane Organization BLOC-1 Complex Synaptic Vesicle Priming Syntaxin-1 Binding Positive Regulation Of T Cell Receptor Signaling Pathway Secretory Granule Localization Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway K63-linked Polyubiquitin Modification-dependent Protein Binding Positive Regulation Of Antigen Receptor-mediated Signaling Pathway Neurotransmitter Uptake B Cell Homeostasis Calcium-ion Regulated Exocytosis Synaptic Vesicle Exocytosis Vesicle Docking Involved In Exocytosis SNAP Receptor Activity Neurotransmitter Secretion Polyubiquitin Modification-dependent Protein Binding Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway SNARE Complex Protein-containing Complex Assembly Negative Regulation Of Response To Endoplasmic Reticulum Stress Regulation Of T Cell Receptor Signaling Pathway Long-term Synaptic Potentiation Voltage-gated Potassium Channel Activity Protein-containing Complex Organization Photoreceptor Inner Segment Vesicle Docking Canonical NF-kappaB Signal Transduction Tertiary Granule Membrane SNARE Binding Lymphocyte Homeostasis Establishment Of Localization In Cell
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