SNAP25 and OSBPL8

Number of citations of the paper that reports this interaction (PubMedID 32734583)
70

Data Source:
BioGRID (protein complementation assay)

		SNAP25	OSBPL8
Description		synaptosome associated protein 25	oxysterol binding protein like 8
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse	Nucleus Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Endomembrane System Membrane Nuclear Membrane Cortical Endoplasmic Reticulum
	Molecular Function	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	Phosphatidylserine Binding Protein Binding Phospholipid Transporter Activity Lipid Binding Cholesterol Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylserine Transfer Activity
	Biological Process	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis	Lipid Transport Phospholipid Transport Negative Regulation Of Cell Migration Phosphatidylserine Acyl-chain Remodeling Fat Cell Differentiation Positive Regulation Of D-glucose Import Positive Regulation Of Insulin Receptor Signaling Pathway Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Triglyceride Homeostasis Protein Localization To Nuclear Pore Intermembrane Lipid Transfer
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Acyl chain remodelling of PS
Drugs		Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS		Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)	Metabolite levels ( 23823483)
Interacting Genes		45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177	4 interacting genes: BTG3 LMNA SNAP25 UBC
Entrez ID		6616	114882
HPRD ID		02637	09478
Ensembl ID		ENSG00000132639	ENSG00000091039
Uniprot IDs		P60880	Q9BZF1
PDB IDs		1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV	1V88 5U77 5U78 8P7A
Enriched GO Terms of Interacting Partners?		SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport	Establishment Or Maintenance Of Microtubule Cytoskeleton Polarity Lamin Filament DNA Double-strand Break Attachment To Nuclear Envelope Nuclear Pore Localization Establishment Of Organelle Localization Structural Constituent Of Nuclear Lamina Ribbon Synapse Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Neuronal Dense Core Vesicle Exocytosis Ventricular Cardiac Muscle Cell Development Negative Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Negative Regulation Of Mesenchymal Cell Proliferation Dense Core Granule Exocytosis Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Calcium Ion-regulated Exocytosis Of Neurotransmitter Vesicle Fusion To Plasma Membrane Nuclear Lamina Organelle Localization Negative Regulation Of Release Of Cytochrome C From Mitochondria Protein Localization To Nuclear Envelope Synaptic Vesicle Docking Somatodendritic Compartment Synaptic Vesicle Membrane Organization BLOC-1 Complex Syntaxin-1 Binding Synaptic Vesicle Priming Protein Tag Activity Regulation Of Cardiac Muscle Hypertrophy In Response To Stress Secretory Granule Localization Nuclear Envelope Organization
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