SNAP25 and OSBP

Number of citations of the paper that reports this interaction (PubMedID 32734583)
70

Data Source:
BioGRID (protein complementation assay)

		SNAP25	OSBP
Description		synaptosome associated protein 25	oxysterol binding protein
Image
GO Annotations	Cellular Component	Photoreceptor Inner Segment Cytoplasm Trans-Golgi Network Cytosol Cytoskeleton Plasma Membrane Cell Cortex Synaptic Vesicle Voltage-gated Potassium Channel Complex Membrane Axon Growth Cone BLOC-1 Complex SNARE Complex Vesicle Specific Granule Membrane Somatodendritic Compartment Presynaptic Membrane Neuron Projection Synapse Perinuclear Region Of Cytoplasm Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Tertiary Granule Membrane Ribbon Synapse Glutamatergic Synapse	Golgi Membrane Nucleoplasm Nucleolus Cytoplasm Endoplasmic Reticulum Endoplasmic Reticulum Membrane Golgi Apparatus Trans-Golgi Network Cytosol Plasma Membrane Membrane Cell Junction Perinuclear Region Of Cytoplasm Perinuclear Endoplasmic Reticulum
	Molecular Function	SNARE Binding Voltage-gated Potassium Channel Activity SNAP Receptor Activity Protein Binding Lipid Binding Syntaxin-1 Binding Calcium-dependent Protein Binding	Protein Binding Oxysterol Binding Lipid Binding Protein Domain Specific Binding Sterol Binding Phosphatidylinositol-4-phosphate Binding Lipid Transfer Activity Sterol Transfer Activity
	Biological Process	Neurotransmitter Uptake Exocytosis Chemical Synaptic Transmission Neurotransmitter Secretion Locomotory Behavior Associative Learning Regulation Of Neuron Projection Development Synaptic Vesicle Exocytosis Synaptic Vesicle Docking Synaptic Vesicle Priming Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Regulation Of Insulin Secretion Long-term Synaptic Potentiation Regulation Of Establishment Of Protein Localization Potassium Ion Transmembrane Transport Presynaptic Dense Core Vesicle Exocytosis	Sphingomyelin Biosynthetic Process Bile Acid Biosynthetic Process Lipid Transport Phospholipid Transport Sterol Transport Intracellular Cholesterol Transport Ceramide Transport Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Intermembrane Lipid Transfer Positive Regulation Of Secretory Granule Organization
Pathways		Serotonin Neurotransmitter Release Cycle Norepinephrine Neurotransmitter Release Cycle Glutamate Neurotransmitter Release Cycle Dopamine Neurotransmitter Release Cycle Acetylcholine Neurotransmitter Release Cycle Regulation of insulin secretion Other interleukin signaling Toxicity of botulinum toxin type A (botA) Toxicity of botulinum toxin type C (botC) Toxicity of botulinum toxin type E (botE) Neutrophil degranulation GABA synthesis, release, reuptake and degradation Sensory processing of sound by inner hair cells of the cochlea	Sphingolipid de novo biosynthesis Synthesis of bile acids and bile salts
Drugs		Botulinum toxin type A Letibotulinumtoxina
Diseases
GWAS		Brain imaging measurements (variance) ( 32047264) Cardiac hypertrophy ( 21348951) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603)
Interacting Genes		45 interacting genes: APP CENPF CPLX1 DNM1 FBXO7 GOSR1 HGS ITSN1 KCNB1 KIF5B NAPA OSBP OSBPL10 OSBPL11 OSBPL2 OSBPL5 OSBPL8 PRKACA PRKCA PRRT2 RIMS1 SCAMP1 SNAPIN SRCIN1 STX11 STX12 STX19 STX1A STX2 STX3 STX4 STX5 STXBP6 SYT1 SYT3 SYT9 TRIM9 UQCC2 VAMP2 VAMP7 VAMP8 WASHC3 ZDHHC17 ZNF177 ZNF559-ZNF177	4 interacting genes: CSNK2A1 SNAP25 VAPA VAPB
Entrez ID		6616	5007
HPRD ID		02637	01327
Ensembl ID		ENSG00000132639	ENSG00000110048
Uniprot IDs		P60880	P22059
PDB IDs		1KIL 1XTG 2N1T 3DDA 3DDB 3RK2 3RK3 3RL0 3ZUR 5W7I 5W7J 6JLH 8BAN 8BAV	2RR3 7V62
Enriched GO Terms of Interacting Partners?		SNARE Binding Membrane Organization SNARE Complex Membrane Fusion Exocytosis Vesicle Fusion SNAP Receptor Activity Organelle Membrane Fusion Vesicle-mediated Transport Organelle Fusion Regulation Of Exocytosis Organelle Localization By Membrane Tethering Vesicle Organization Secretion By Cell Membrane Docking Vesicle Docking Protein Transport Regulation Of Vesicle-mediated Transport Establishment Of Protein Localization Regulation Of Secretion By Cell Establishment Of Localization In Cell Secretion Regulation Of Secretion Intracellular Protein Localization Cellular Localization Intracellular Transport Organelle Localization Synapse Regulation Of Transport Regulation Of Regulated Secretory Pathway Positive Regulation Of Transport Modulation Of Chemical Synaptic Transmission Synaptic Vesicle Fusion To Presynaptic Active Zone Membrane Vesicle Fusion To Plasma Membrane Positive Regulation Of Exocytosis Intracellular Protein Transport Regulation Of Hormone Secretion Endomembrane System SNARE Complex Assembly Vesicle-mediated Transport In Synapse Cytoplasmic Vesicle Positive Regulation Of Secretion By Cell Synaptic Vesicle Exocytosis Regulated Exocytosis Synaptic Vesicle Membrane Organization Positive Regulation Of Secretion Protein-containing Complex Organization Synaptic Vesicle Membrane Positive Regulation Of Regulated Secretory Pathway Neurotransmitter Transport	FFAT Motif Binding COPII-coated Vesicle Budding Endoplasmic Reticulum-plasma Membrane Tethering Organelle Localization By Membrane Tethering Membrane Docking Endoplasmic Reticulum Localization Organelle Localization Host-mediated Activation Of Viral Genome Replication Host-mediated Perturbation Of Viral Genome Replication Host-mediated Suppression Of Viral Genome Replication Viral Release From Host Cell Endoplasmic Reticulum Exit Site Vesicle Budding From Membrane Protein-membrane Adaptor Activity Host-mediated Activation Of Viral Process Cadherin Binding Vesicle Organization Organelle Organization Endoplasmic Reticulum Organization Cholesterol Transport Host-mediated Perturbation Of Viral Process Sterol Transport Establishment Of Localization In Cell Host-mediated Perturbation Of Symbiont Process Modulation Of Process Of Another Organism Membrane Organization Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Negative Regulation By Virus Of Viral Protein Levels In Host Cell Viral Process Protein Kinase CK2 Complex Symbiont-mediated Disruption Of Host Cell PML Body Membrane Fusion Biological Process Involved In Interaction With Host Organic Hydroxy Compound Transport Establishment Or Maintenance Of Cell Polarity Regulating Cell Shape Vesicle Synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I Complex Presynaptic Dense Core Vesicle Exocytosis Plasma Membrane Protein Folding Positive Regulation Of Aggrephagy Microtubule Bundle Ribbon Synapse Regulation Of Neurofibrillary Tangle Assembly Neuronal Dense Core Vesicle Exocytosis Host-mediated Perturbation Of Viral RNA Genome Replication Microtubule Binding Regulation Of Biological Quality Dense Core Granule Exocytosis Wnt Signaling Pathway
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