NTAQ1 and XIAP

Number of citations of the paper that reports this interaction (PubMedID 27107012)
72

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NTAQ1	XIAP
Description		N-terminal glutamine amidase 1	X-linked inhibitor of apoptosis
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding Protein-N-terminal Asparagine Amidohydrolase Activity Hydrolase Activity Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Linear Amides Protein-N-terminal Glutamine Amidohydrolase Activity	Ubiquitin-protein Transferase Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Zinc Ion Binding Transferase Activity Peptidase Inhibitor Activity Identical Protein Binding Cysteine-type Endopeptidase Inhibitor Activity Involved In Apoptotic Process Metal Ion Binding Ubiquitin Protein Ligase Activity Protein Serine/threonine Kinase Binding
	Biological Process	Protein Modification Process	Ubiquitin-dependent Protein Catabolic Process Apoptotic Process DNA Damage Response Canonical NF-kappaB Signal Transduction Negative Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Wnt Signaling Pathway Regulation Of BMP Signaling Pathway Positive Regulation Of Protein Ubiquitination Negative Regulation Of Type I Interferon Production Positive Regulation Of Type I Interferon Production Response To Lipopolysaccharide P38MAPK Cascade Defense Response To Bacterium Regulation Of Apoptotic Process Negative Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Innate Immune Response Positive Regulation Of JNK Cascade Regulation Of Inflammatory Response Neuron Apoptotic Process Regulation Of Cell Cycle Copper Ion Homeostasis Regulation Of Apoptosis Involved In Tissue Homeostasis Regulation Of Nucleotide-binding Domain, Leucine Rich Repeat Containing Receptor Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 1 Signaling Pathway Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Protein K63-linked Ubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Protein Linear Polyubiquitination Execution Phase Of Apoptosis Positive Regulation Of Protein Linear Polyubiquitination
Pathways			Activation of caspases through apoptosome-mediated cleavage SMAC (DIABLO) binds to IAPs SMAC (DIABLO) binds to IAPs SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC(DIABLO)-mediated dissociation of IAP:caspase complexes SMAC, XIAP-regulated apoptotic response Deactivation of the beta-catenin transactivating complex RIPK1-mediated regulated necrosis TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling TNFR1-induced NF-kappa-B signaling pathway Regulation of necroptotic cell death Regulation of PTEN localization Regulation of PTEN stability and activity Regulation of the apoptosome activity
Drugs			1-[3,3-Dimethyl-2-(2-Methylamino-Propionylamino)-Butyryl]-Pyrrolidine-2-Carboxylic Acid(1,2,3,4-Tetrahydro-Naphthalen-1-Yl)-Amide Dequalinium N-METHYLALANYL-3-METHYLVALYL-4-PHENOXY-N-(1,2,3,4-TETRAHYDRONAPHTHALEN-1-YL)PROLINAMIDE AEG35156 Terpinen-4-ol
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes		379 interacting genes: - AARD ACD ACOT13 ACTB ACTG1 ACTN2 ACY1 ADAMTSL4 AGR2 AGR3 AIMP2 AKIRIN2 AMOT AMOTL2 AMPD2 ANKRD11 ANKRD36B AOC1 APIP ARID4B ARL6IP1 ASL ATP6V1G1 BANF2 BCL2L2-PABPN1 BEND5 BIRC7 BLMH BLOC1S6 BLZF1 BOLA2 BOLA2B BORCS6 BPIFB3 BTBD2 BTBD6 C1orf50 CAMK2A CAPN3 CARD9 CASP6 CAVIN4 CBFA2T2 CBS CBY2 CCDC102B CCDC152 CCDC184 CCDC197 CCHCR1 CCNB1IP1 CD22 CDA CDCA8 CDK2AP1 CDKN2AIPNL CDR2 CENPP CEP170B CEP55 CEP70 CEP85 CGGBP1 CHCHD3 CHMP4A CMTM5 COG6 COIL CRYAA CSNK2B CT45A1 CTAG1A CTAG1B CTBP1 CTH CUEDC1 CUTC CYSRT1 DAB1 DCTPP1 DEUP1 DHPS DNAL4 DNM2 DYNLT1 EDARADD EGLN3 EIF2B1 EIF4G1 EMILIN3 ENOX2 EP400 EPN3 ETV6 EXOSC8 FAM136A FAM72A FAM72D FKBP6 FTH1 FTL GADD45GIP1 GAS7 GCSAML GFAP GMCL1 GMDS GNG3 GNMT GNPDA2 GOLGA2 GOLGA6L9 GPX7 GRAMD4 GSTA4 GSTO2 GTF2H2C H2AP HAUS8 HBQ1 HBZ HEATR5A HGD HIGD1C HMG20A HOMER3 HOXB6 HPRT1 HSD17B14 HSF2BP HSPE1 HUS1 IKZF3 IL16 IL31 INCA1 ISCA2 ITGB3BP JAKMIP2 JUP KASH5 KATNBL1 KCNH1 KCTD1 KCTD10 KCTD13 KCTD15 KCTD21 KCTD4 KCTD6 KCTD7 KCTD9 KEAP1 KIF21B KLHL12 KLHL2 KLHL20 KRT27 KRT31 KRTAP10-5 KRTAP10-7 KRTAP19-2 KRTAP19-6 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-9 KRTAP6-1 KRTAP9-2 KRTAP9-4 KRTAP9-8 L3MBTL3 LCE1C LCE1D LCE1E LCE1F LCE2C LCE5A LDB2 LENG1 LGALS2 LGALS9B LIN7B LMNA LMO1 LMO2 LMO3 LNX2 LONRF1 LRIF1 LRRC73 LSM12 LSM14B LZTFL1 LZTS1 LZTS2 MAB21L3 MAD1L1 MAGEA11 MAGEA12 MAGEA2 MAGEA2B MALSU1 MARCHF10 MATN4 MDFI MED22 MIF MIF4GD MIOS MIPOL1 MIS18A MITD1 MOB2 MORN3 MPLKIP MRFAP1L1 MRPL12 MTHFD2L MTUS2 MVP MXRA8 MYD88 N4BP3 NAB2 NADSYN1 NAGK NCOA5 NDUFAB1 NECAB2 NME1 NPL NR5A1 NT5C1A NTAN1 NUDT14 NUDT16L1 NUDT21 OOEP PAK5 PCBD1 PFDN5 PGPEP1 PIH1D2 PLA2G10 PLCD1 PLEKHB2 PLEKHJ1 PNMA1 PNMA2 PNMA5 POLR2J POMC PPCDC PPM1K PPP1R27 PRKAR1B PRMT1 PRMT5 PRPS2 PRR20A PRR20B PRR20C PRR20D PRR20E PRR23B PRTFDC1 PSMB5 PSME3 PTS PYCR3 PYGM RAB42 RABAC1 RASAL3 RBBP8 RBM20 RBM45 RBM48 RBPMS RD3 REEP6 RHOQ RILPL1 RNF138 RNF4 ROPN1 RPIA RUSC1 S100A11 SAP18 SARS2 SAT1 SCARA5 SELENOV SEPTIN14 SEPTIN3 SFN SH3GLB2 SIAH1 SIKE1 SIVA1 SLAIN1 SLC15A2 SLPI SMAP1 SMN1 SNAP29 SNRPD3 SPANXB1 SPATA32 SPDYE4 SPINDOC SPRYD7 SSNA1 SSX2IP STH STMN2 STN1 STX11 SYCE1L SYNGAP1 TAX1BP1 TBX15 TCL1A TCP10L TEKT1 TEPSIN THAP1 THAP6 THAP7 THG1L TICAM2 TIFA TLE5 TMEM239 TNFAIP1 TNIP3 TNR TOLLIP TRAF1 TRAF3 TRAF5 TRIM23 TRIM27 TRIM32 TRIM5 TRIM54 TRIM69 TRIM73 TRIM9 TRIP13 TSC22D1 TSN TSNAX UBR1 UBR2 UFC1 UNKL VAC14 VCP VDR VMA22 VPS37C VXN XIAP ZBED1 ZBTB8A ZBTB8B ZC2HC1C ZCCHC17 ZNF165 ZNF341 ZNF436 ZNF511 ZNF618 ZSCAN16 ZSCAN32	105 interacting genes: ACVRL1 AFP AIFM1 AKT1 AKT2 BCL2 BIRC5 BOLA1 BOLA2 BOLA2B BRCA1 CAD CASP10 CASP3 CASP7 CASP9 CCNB1 CDC42 CDK1 CHEK1 CKS1B COMMD1 DIABLO DNM2 DTX3 DYNLL2 EEF2 ERCC3 FAF1 FLNA FLNB GCC1 GOLGA2 GSK3B GSPT1 HNRNPA1 HSP90AB1 HSPA1A HTRA1 HTRA2 HTRA3 IKBKE INPP5D KCNJ6 LIMA1 LONRF1 MAGED1 MAP3K2 MAP3K3 MAP3K7 MCRS1 MDM2 NCOA6 NEK6 NOD1 NOD2 NOTCH1 NTAQ1 OGT PGAM5 PIBF1 PPIH PPM1K QARS1 RAF1 RFC5 RIPK3 RIPK4 RPS9 RUNX1T1 SDHA SEPTIN4 SERPINA12 SERTAD1 SSX2IP STRADB STUB1 SYNE1 TAB1 TAB2 TBK1 TGFBR1 TPM3 TRAF6 TRIM32 TRIM8 TTC23 TUFM UBB UBC UBE2D1 UBE2D2 UBE2D3 UBE2D4 UBE2E1 UBE2E2 UBE2I UBE2J2 UBE2L3 UBE2N UBE2V1 UBE2V2 UBE2W VPS37C XAF1
Entrez ID		55093	331
HPRD ID		07653	02094
Ensembl ID		ENSG00000156795	ENSG00000101966
Uniprot IDs		E5RHC2 Q96HA8	B2R9R2 P98170
PDB IDs		3C9Q 4W79 6KGJ 8JJF 8JJG 8JJH 8JJI 8JJU 8JJW 8JJX 8JJY 8JJZ 8JK0 8JK1 8JK2	1C9Q 1F9X 1G3F 1G73 1I3O 1I4O 1I51 1KMC 1NW9 1TFQ 1TFT 2ECG 2JK7 2KNA 2OPY 2OPZ 2POI 2POP 2QRA 2VSL 3CLX 3CM2 3CM7 3EYL 3G76 3HL5 3UW4 3UW5 4EC4 4HY0 4IC2 4IC3 4J3Y 4J44 4J45 4J46 4J47 4J48 4KJU 4KJV 4KMP 4MTZ 4OXC 4WVS 4WVT 4WVU 5C0K 5C0L 5C3H 5C3K 5C7A 5C7B 5C7C 5C7D 5C83 5C84 5M6E 5M6F 5M6H 5M6L 5M6M 5O6T 5OQW 6EY2 6GJW 6QCI 8AZA 8GH7 8W59 8W5A
Enriched GO Terms of Interacting Partners?		Identical Protein Binding Protein Binding Cytosol Protein Homooligomerization Protein Complex Oligomerization Cytoplasm Intermediate Filament Protein Ubiquitination Protein Modification By Small Protein Conjugation Negative Regulation Of Protein Sumoylation Keratin Filament Sulfur Amino Acid Metabolic Process Regulation Of Protein Sumoylation Protein-containing Complex Assembly Keratinization Ubiquitin-protein Transferase Activity N-acetylneuraminate Catabolic Process Protein Tetramerization Purine Nucleoside Metabolic Process Amino Acid Metabolic Process Cul3-RING Ubiquitin Ligase Complex	Protein Metabolic Process Protein Modification Process Protein Polyubiquitination Cytosol Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Ubiquitin Conjugating Enzyme Activity Regulation Of Signal Transduction Nucleotide Binding Programmed Cell Death Cell Death Regulation Of Protein Ubiquitination Regulation Of Programmed Cell Death Positive Regulation Of Protein Metabolic Process Regulation Of Apoptotic Process Post-translational Protein Modification ATP Binding Protein Ubiquitination Ubiquitin Protein Ligase Binding Cytoplasm Regulation Of Signaling Positive Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Cell Communication Protein Modification By Small Protein Conjugation Apoptotic Process Regulation Of Protein Modification Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Modification Process Regulation Of Post-translational Protein Modification Cellular Response To Stress Positive Regulation Of Signal Transduction Protein K63-linked Ubiquitination Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Protein Metabolic Process Positive Regulation Of Programmed Cell Death Positive Regulation Of Protein Ubiquitination Protein-containing Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Protein Binding Transferase Activity Positive Regulation Of Post-translational Protein Modification Modification-dependent Protein Catabolic Process Proteolysis Macromolecule Catabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway
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