JARID2 and NKX2-5

Number of citations of the paper that reports this interaction (PubMedID 15542826)
50

Data Source:
HPRD (in vitro, in vivo)

		JARID2	NKX2-5
Description		jumonji and AT-rich interaction domain containing 2	NK2 homeobox 5
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Mitochondrion Histone Methyltransferase Complex ESC/E(Z) Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Cytoplasm Cytosol Protein-containing Complex Protein-DNA Complex RNA Polymerase II Transcription Regulator Complex Nkx-2.5 Complex
	Molecular Function	DNA Binding Chromatin Binding Protein Binding Histone Demethylase Activity Ubiquitin Binding Histone H3K27 Methyltransferase Activity Ubiquitin-modified Histone Reader Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Protein Homodimerization Activity Sequence-specific DNA Binding RNA Polymerase II-specific DNA-binding Transcription Factor Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Liver Development Chromatin Organization Chromatin Remodeling Central Nervous System Development Cell Population Proliferation Regulation Of Gene Expression Cell Differentiation Regulation Of Cell Population Proliferation Negative Regulation Of DNA-templated Transcription Spleen Development Thymus Development System Development Stem Cell Differentiation Cardiac Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Proliferation Random Inactivation Of X Chromosome Facultative Heterochromatin Formation Protein Localization To Pericentric Heterochromatin Cellular Response To Leukemia Inhibitory Factor	Negative Regulation Of Transcription By RNA Polymerase II Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Outflow Tract Morphogenesis Cardiac Conduction System Development Atrioventricular Node Development Bundle Of His Development Purkinje Myocyte Differentiation Aortic Valve Morphogenesis Cardiac Ventricle Morphogenesis Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Atrial Cardiac Muscle Tissue Development Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Apoptotic Process Heart Development Adult Heart Development Cell Population Proliferation Positive Regulation Of Cell Population Proliferation Positive Regulation Of Gene Expression Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation Epithelial Cell Differentiation Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of DNA-templated Transcription Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Spleen Development Cardiac Muscle Tissue Development Epithelial Cell Proliferation Positive Regulation Of Epithelial Cell Proliferation Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Cell Development Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Heart Contraction Cardiac Muscle Contraction Positive Regulation Of Transcription Initiation By RNA Polymerase II Heart Trabecula Formation Cardiac Septum Morphogenesis Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cardiac Conduction Epithelial Cell Apoptotic Process Negative Regulation Of Epithelial Cell Apoptotic Process
Pathways		PRC2 methylates histones and DNA	YAP1- and WWTR1 (TAZ)-stimulated gene expression Physiological factors Cardiogenesis Cardiogenesis
Drugs
Diseases			Tetralogy of Fallot Congenital nongoitrous hypothyroidism (CHNG) Atrial septal defect
GWAS		Appendicular lean mass ( 33097823) Birth weight ( 31043758) Chronotype ( 30696823) Hand grip strength ( 29691431) Hip circumference adjusted for BMI ( 34021172) Lymphocyte count ( 32888494) Lymphoma ( 23349640) Multiple myeloma ( 27363682) Multiple sclerosis (severity) ( 19010793) Nevus count or cutaneous melanoma ( 32341527) Ovarian reserve ( 22116950)	Atrial fibrillation ( 29892015 30061737) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060 30046033 32439900) Resting heart rate ( 27798624) Stroke ( 26089329) TPE interval (resting) ( 32386560)
Interacting Genes		3 interacting genes: GATA4 NKX2-5 SETDB1	19 interacting genes: CAMTA2 CSNK2A1 FBXO25 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A KPNA4 KRTAP8-1 RBPMS SHOX SRF TBX2 TBX5 TLE1 TRIP10
Entrez ID		3720	1482
HPRD ID		03355	02787
Ensembl ID		ENSG00000008083	ENSG00000183072
Uniprot IDs		Q92833	A0A0S2Z383 A0A0S2Z3K2 E5RH49 P52952
PDB IDs		4X3E 5HYN 5LS6 5WAI 6C23 6C24 6NQ3 6WKR 7KSO 8TB9 8VMI 8VML 8VNV 8VNZ 9C8U 9DCH	3RKQ 4S0H 6WC2 6WC5
Enriched GO Terms of Interacting Partners?		Atrioventricular Node Development Atrial Septum Morphogenesis Aortic Valve Morphogenesis Cardiac Muscle Cell Differentiation Negative Regulation Of Striated Muscle Cell Apoptotic Process Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Cardiac Ventricle Morphogenesis DNA-binding Transcription Activator Activity Cardiac Septum Development Cardiocyte Differentiation Regulation Of Cardiac Muscle Cell Apoptotic Process Negative Regulation Of Muscle Cell Apoptotic Process Heart Valve Morphogenesis Mesenchyme Development Cardiac Muscle Tissue Development Heart Looping Embryonic Heart Tube Morphogenesis Striated Muscle Cell Differentiation Cardiac Septum Morphogenesis Regulation Of Cardiac Muscle Contraction Regulation Of Striated Muscle Contraction Muscle Cell Differentiation Epithelial Tube Morphogenesis Striated Muscle Tissue Development Septum Secundum Development Nkx-2.5 Complex Purkinje Myocyte Differentiation RNA Polymerase II Transcription Regulator Complex Muscle Tissue Development Regulation Of Muscle Contraction Atrial Cardiac Muscle Cell Development Atrioventricular Node Cell Fate Commitment Cell Fate Commitment Atrial Septum Secundum Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Regulation Of Heart Contraction His-Purkinje System Cell Differentiation Pulmonary Myocardium Development Proepicardium Development Ventricular Cardiac Myofibril Assembly Right Ventricular Cardiac Muscle Tissue Morphogenesis Embryonic Heart Tube Anterior/posterior Pattern Specification Regulation Of Blood Circulation Positive Regulation Of Cardioblast Differentiation Atrioventricular Node Cell Development Bundle Of His Development Transcription Cis-regulatory Region Binding Regulation Of Muscle System Process Cardiac Muscle Tissue Regeneration Histone H3K9 Trimethyltransferase Activity	Embryonic Morphogenesis DNA-binding Transcription Factor Binding Cardiocyte Differentiation Sequence-specific DNA Binding Embryonic Camera-type Eye Morphogenesis Heart Looping Nucleoplasm Embryonic Heart Tube Morphogenesis Chromatin Nucleus Anatomical Structure Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Polymerase II-specific DNA-binding Transcription Factor Binding Aorta Morphogenesis Positive Regulation Of Macromolecule Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Blood Vessel Morphogenesis Positive Regulation Of Macromolecule Biosynthetic Process Embryonic Heart Tube Anterior/posterior Pattern Specification Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Transcription By RNA Polymerase II Embryonic Eye Morphogenesis Positive Regulation Of Biosynthetic Process Epithelial Tube Morphogenesis Muscle Cell Differentiation Transcription Regulator Complex Lens Induction In Camera-type Eye Positive Regulation Of RNA Metabolic Process Regulation Of Gene Expression Regulation Of RNA Metabolic Process Histone Deacetylase Binding Positive Regulation Of Metabolic Process Regulation Of Cardiac Muscle Cell Proliferation Regulation Of Macromolecule Biosynthetic Process Tube Morphogenesis Animal Organ Morphogenesis Negative Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Nucleobase-containing Compound Metabolic Process Muscle Tissue Development Embryonic Retina Morphogenesis In Camera-type Eye Morphogenesis Of An Epithelium Anterior/posterior Pattern Specification Iris Morphogenesis Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Cell Population Proliferation Eye Morphogenesis Positive Regulation Of Cell Population Proliferation
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?