JARID2 and NKX2-5

Number of citations of the paper that reports this interaction (PMID 15542826)
20

Data Source:
HPRD (in vitro, in vivo)

		JARID2	NKX2-5
Gene Name		jumonji, AT rich interactive domain 2	NK2 homeobox 5
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex ESC/E(Z) Complex	Nucleus Transcription Factor Complex Cytoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Chromatin Binding Histone Demethylase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription RNA Polymerase II Transcription Cofactor Activity RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Involved In Positive Regulation Of Transcription DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Protein Binding Transcription Factor Binding Serum Response Element Binding Protein Homodimerization Activity Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding Protein Heterodimerization Activity
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Transcription, DNA-templated Central Nervous System Development Negative Regulation Of Cell Proliferation Gene Expression Chromatin Modification Negative Regulation Of Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Spleen Development Thymus Development Stem Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation	Negative Regulation Of Transcription From RNA Polymerase II Promoter Vasculogenesis Heart Looping Heart Morphogenesis Outflow Tract Septum Morphogenesis Cardiac Conduction System Development Bundle Of His Development Purkinje Myocyte Differentiation Cardiac Ventricle Formation Right Ventricular Cardiac Muscle Tissue Morphogenesis Ventricular Trabecula Myocardium Morphogenesis Apoptotic Process Involved In Heart Morphogenesis Septum Secundum Development Proepicardium Development Pulmonary Myocardium Development Transcription From RNA Polymerase II Promoter Adult Heart Development Positive Regulation Of Cell Proliferation Negative Regulation Of Cardiac Muscle Cell Apoptotic Process Positive Regulation Of Transcription Via Serum Response Element Binding Positive Regulation Of Sodium Ion Transport Negative Regulation Of Myotube Differentiation Hemopoiesis Cell Differentiation BMP Signaling Pathway Thyroid Gland Development Embryonic Heart Tube Development Negative Regulation Of Apoptotic Process Sarcomere Organization Positive Regulation Of Neuron Differentiation Positive Regulation Of Heart Contraction Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Spleen Development Positive Regulation Of Cardioblast Differentiation Ventricular Cardiac Myofibril Assembly Cardiac Muscle Cell Differentiation Cardiac Muscle Tissue Morphogenesis Atrial Cardiac Muscle Cell Development Ventricular Cardiac Muscle Cell Development Regulation Of Cardiac Muscle Contraction Pharyngeal System Development Cardiac Muscle Cell Proliferation Regulation Of Cardiac Muscle Cell Proliferation Cardiac Muscle Contraction Canonical Wnt Signaling Pathway Positive Regulation Of Transcription Initiation From RNA Polymerase II Promoter Heart Trabecula Formation Ventricular Septum Morphogenesis Atrial Septum Morphogenesis Atrioventricular Node Cell Development Atrioventricular Node Cell Fate Commitment Embryonic Heart Tube Left/right Pattern Formation Negative Regulation Of Canonical Wnt Signaling Pathway Positive Regulation Of Voltage-gated Calcium Channel Activity
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Generic Transcription Pathway YAP1- and WWTR1 (TAZ)-stimulated gene expression
Drugs
Diseases
GWAS		Lymphoma ( 23349640) Multiple sclerosis (severity) ( 19010793) Ovarian reserve ( 22116950)	Heart rate ( 23583979) Infantile hypertrophic pyloric stenosis ( 22306654) PR interval ( 20062060)
Protein-Protein Interactions		3 interactors: GATA4 NKX2-5 SETDB1	13 interactors: CAMTA2 CSNK2A1 FOXH1 GATA4 HDAC1 HIPK1 HIPK2 JARID2 KDM6A SRF TBX2 TBX5 TLE1
Entrez ID		3720	1482
HPRD ID		03355	02787
Ensembl ID		ENSG00000008083	ENSG00000183072
Uniprot IDs		F5H590 Q92833	P52952
PDB IDs			3RKQ
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardioblast Differentiation Septum Secundum Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Development Cardiac Atrium Morphogenesis Cardiac Muscle Tissue Growth Regulation Of Cardiac Muscle Cell Proliferation Growth Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Cardiac Septum Morphogenesis Regulation Of Heart Growth Regulation Of Cardiac Muscle Tissue Development Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Cardiac Muscle Cell Development Cardiac Ventricle Morphogenesis Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Cardiac Septum Development Embryonic Heart Tube Development Regulation Of Striated Muscle Contraction Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Canonical Wnt Signaling Pathway Organ Growth Regulation Of Organ Growth Cardiac Ventricle Development Determination Of Left/right Symmetry Cardiac Muscle Cell Differentiation Determination Of Bilateral Symmetry Cardiocyte Differentiation Regulation Of Striated Muscle Tissue Development Cardiac Chamber Development Embryo Development Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Lung Lobe Formation Regulation Of Muscle Contraction Striated Muscle Cell Development Regulation Of Heart Contraction Muscle Cell Development Cardiac Muscle Tissue Development Mesenchyme Development Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrioventricular Node Cell Development Heart Morphogenesis	Organ Morphogenesis Embryonic Morphogenesis Transcription, DNA-templated RNA Biosynthetic Process Embryonic Organ Morphogenesis Tissue Morphogenesis Anatomical Structure Formation Involved In Morphogenesis RNA Metabolic Process Embryo Development Anatomical Structure Morphogenesis Heart Morphogenesis Gene Expression Regulation Of Gene Expression Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Pattern Specification Process Anterior/posterior Pattern Specification Embryonic Organ Development Macromolecule Biosynthetic Process Regulation Of Cell Proliferation Cardiac Chamber Development Organ Development System Development Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of RNA Metabolic Process Nucleobase-containing Compound Metabolic Process Tissue Development Cardiac Muscle Tissue Development Multicellular Organismal Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Biosynthetic Process Anatomical Structure Development Regulation Of Nitrogen Compound Metabolic Process Positive Regulation Of Growth Positive Regulation Of Cell Proliferation Cellular Nitrogen Compound Metabolic Process Transcription From RNA Polymerase II Promoter Heart Development Developmental Process Nitrogen Compound Metabolic Process Positive Regulation Of Gene Expression Aorta Morphogenesis Regulation Of Metabolic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Cardiac Muscle Cell Proliferation Aorta Development Striated Muscle Tissue Development
Tagcloud ?		a549 antagonized catalyzes cdh1 colon conversion crucial discovered emt ezh2 h3k27 ht29 immunoprecipitation interacting knockdown mesenchymal methylation microrna morphological occupancies polycomb prc2 repression repressive ss tgf transforming transition zeb
Tagcloud (Difference) ?		a549 antagonized catalyzes cdh1 colon conversion crucial discovered emt ezh2 h3k27 ht29 immunoprecipitation interacting knockdown mesenchymal methylation microrna morphological occupancies polycomb prc2 repression repressive ss tgf transforming transition zeb
Tagcloud (Intersection) ?