JARID2 and GATA4

Number of citations of the paper that reports this interaction (PMID 15542826)
20

Data Source:
BioGRID (pull down)
HPRD (in vitro, in vivo)

		JARID2	GATA4
Gene Name		jumonji, AT rich interactive domain 2	GATA binding protein 4
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Nucleus Nucleoplasm Histone Methyltransferase Complex ESC/E(Z) Complex	Nuclear Chromatin Nucleus Nucleoplasm RNA Polymerase II Transcription Factor Complex
	Molecular Function	DNA Binding Chromatin Binding Histone Demethylase Activity	RNA Polymerase II Core Promoter Proximal Region Sequence-specific DNA Binding RNA Polymerase II Transcription Factor Binding Transcription Factor Activity Enhancer Sequence-specific DNA Binding DNA Binding Chromatin Binding Sequence-specific DNA Binding Transcription Factor Activity RNA Polymerase II Distal Enhancer Sequence-specific DNA Binding Transcription Factor Activity Transcription Coactivator Activity Protein Binding Transcription Factor Binding Zinc Ion Binding Activating Transcription Factor Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding NFAT Protein Binding Co-SMAD Binding
	Biological Process	Negative Regulation Of Transcription From RNA Polymerase II Promoter Liver Development Transcription, DNA-templated Central Nervous System Development Negative Regulation Of Cell Proliferation Gene Expression Chromatin Modification Negative Regulation Of Histone Methylation Regulation Of Gene Expression, Epigenetic Negative Regulation Of Gene Expression, Epigenetic Negative Regulation Of Transcription, DNA-templated Spleen Development Thymus Development Stem Cell Differentiation Positive Regulation Of Histone H3-K9 Methylation	In Utero Embryonic Development Gastrulation With Mouth Forming Second Endoderm Formation Heart Looping Atrioventricular Valve Formation Endocardial Cushion Development Cardiac Ventricle Morphogenesis Cardiac Right Ventricle Morphogenesis Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Atrial Septum Primum Morphogenesis Atrial Septum Secundum Morphogenesis Regulation Of Transcription, DNA-templated Transcription From RNA Polymerase II Promoter Cell-cell Signaling Spermatogenesis Endoderm Development Blood Coagulation Male Gonad Development Response To Mechanical Stimulus Negative Regulation Of Autophagy Positive Regulation Vascular Endothelial Growth Factor Production Cardiac Muscle Hypertrophy In Response To Stress Signal Transduction Involved In Regulation Of Gene Expression BMP Signaling Pathway Positive Regulation Of BMP Signaling Pathway Response To Retinoic Acid Embryonic Heart Tube Anterior/posterior Pattern Specification Atrioventricular Canal Development Response To Drug Response To Estrogen Positive Regulation Of Angiogenesis Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Embryonic Digestive Tract Morphogenesis Embryonic Foregut Morphogenesis Positive Regulation Of Cardioblast Differentiation Sertoli Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Canonical Wnt Signaling Pathway Transdifferentiation SMAD Protein Signal Transduction Atrial Septum Morphogenesis Lung Lobe Formation Intestinal Epithelial Cell Differentiation Cell Growth Involved In Cardiac Muscle Cell Development Cellular Response To Glucose Stimulus Cellular Response To Follicle-stimulating Hormone Stimulus Epithelial Cell Fate Commitment Seminiferous Tubule Development Regulation Of Cardiac Muscle Cell Contraction
Pathways		Epigenetic regulation of gene expression PRC2 methylates histones and DNA	Peptide hormone metabolism Generic Transcription Pathway Synthesis, secretion, and inactivation of Glucose-dependent Insulinotropic Polypeptide (GIP) YAP1- and WWTR1 (TAZ)-stimulated gene expression Factors involved in megakaryocyte development and platelet production Incretin synthesis, secretion, and inactivation
Drugs
Diseases
GWAS		Lymphoma ( 23349640) Multiple sclerosis (severity) ( 19010793) Ovarian reserve ( 22116950)	Myopia (pathological) ( 23049088) Retinal vascular caliber ( 21060863)
Protein-Protein Interactions		3 interactors: GATA4 NKX2-5 SETDB1	23 interactors: ALX4 CRIP2 EP300 FOS HAND2 ID1 ID2 ID3 JARID2 MAPK1 MAPK3 MDC1 MED1 MEF2C NFATC4 NKX2-5 NR5A1 PIAS1 SP1 SRF TBX5 ZBTB3 ZFPM2
Entrez ID		3720	2626
HPRD ID		03355	08994
Ensembl ID		ENSG00000008083	ENSG00000136574
Uniprot IDs		F5H590 Q92833	B3KUF4 B7ZKZ4 P43694
PDB IDs			2M9W
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Cardioblast Differentiation Septum Secundum Development Atrial Septum Morphogenesis Cardiac Right Ventricle Morphogenesis Atrial Septum Development Cardiac Atrium Morphogenesis Cardiac Muscle Tissue Growth Regulation Of Cardiac Muscle Cell Proliferation Growth Positive Regulation Of Stem Cell Differentiation Ventricular Cardiac Muscle Tissue Development Ventricular Septum Development Cardiac Septum Morphogenesis Regulation Of Heart Growth Regulation Of Cardiac Muscle Tissue Development Heart Looping Determination Of Heart Left/right Asymmetry Embryonic Heart Tube Morphogenesis Cardiac Muscle Cell Development Cardiac Ventricle Morphogenesis Regulation Of Cardiac Muscle Contraction BMP Signaling Pathway Cardiac Septum Development Embryonic Heart Tube Development Regulation Of Striated Muscle Contraction Chordate Embryonic Development Embryo Development Ending In Birth Or Egg Hatching Canonical Wnt Signaling Pathway Organ Growth Regulation Of Organ Growth Cardiac Ventricle Development Determination Of Left/right Symmetry Cardiac Muscle Cell Differentiation Determination Of Bilateral Symmetry Cardiocyte Differentiation Regulation Of Striated Muscle Tissue Development Cardiac Chamber Development Embryo Development Purkinje Myocyte Differentiation Atrioventricular Node Cell Fate Commitment Lung Lobe Formation Regulation Of Muscle Contraction Striated Muscle Cell Development Regulation Of Heart Contraction Muscle Cell Development Cardiac Muscle Tissue Development Mesenchyme Development Right Ventricular Cardiac Muscle Tissue Morphogenesis Atrioventricular Node Cell Development Heart Morphogenesis	Transcription, DNA-templated RNA Biosynthetic Process Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Transcription, DNA-templated Tissue Development RNA Metabolic Process Heart Development Positive Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Gene Expression Gene Expression Organ Morphogenesis Positive Regulation Of Cellular Biosynthetic Process Positive Regulation Of Transcription From RNA Polymerase II Promoter Cellular Macromolecule Biosynthetic Process Organ Development Macromolecule Biosynthetic Process Nucleobase-containing Compound Metabolic Process Cardiovascular System Development Cardiac Chamber Development Tube Development Heterocycle Metabolic Process Cellular Aromatic Compound Metabolic Process Cellular Nitrogen Compound Metabolic Process Regulation Of Transcription, DNA-templated Regulation Of Nucleic Acid-templated Transcription Cardiac Ventricle Development Regulation Of RNA Biosynthetic Process Positive Regulation Of Cellular Metabolic Process Regulation Of RNA Metabolic Process Nitrogen Compound Metabolic Process Embryonic Organ Development Muscle Structure Development Biosynthetic Process Regulation Of Gene Expression System Development Regulation Of Nitrogen Compound Metabolic Process Epithelium Development Embryo Development Striated Muscle Tissue Development Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Multicellular Organismal Development Positive Regulation Of Metabolic Process Muscle Tissue Development Anatomical Structure Morphogenesis Blood Vessel Development Anatomical Structure Development Heart Morphogenesis Vasculature Development Negative Regulation Of Transcription From RNA Polymerase II Promoter Cardiac Ventricle Morphogenesis
Tagcloud ?		a549 antagonized catalyzes cdh1 colon conversion crucial discovered emt ezh2 h3k27 ht29 immunoprecipitation interacting knockdown mesenchymal methylation microrna morphological occupancies polycomb prc2 repression repressive ss tgf transforming transition zeb	6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Difference) ?		a549 antagonized catalyzes cdh1 colon conversion crucial discovered emt ezh2 h3k27 ht29 immunoprecipitation interacting knockdown mesenchymal methylation microrna morphological occupancies polycomb prc2 repression repressive ss tgf transforming transition zeb	6j arm assigned assignment backcross c57bl chromosome closely clu determination disorganization dnas ds ectopic f1 hybrid kb lineage mapped mapping mus places rodent somatic southern speculate spretus vicinity
Tagcloud (Intersection) ?