IVL and LORICRIN

Number of citations: 0 (PubMedID 8999895)
Data Source: BioGRID (pull down)

		IVL	LORICRIN
Name		involucrin	loricrin cornified envelope precursor protein
Structure		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Centrosome Cytosol Nuclear Body Extracellular Exosome	Cornified Envelope Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Protein Binding	Structural Constituent Of Cytoskeleton Protein Binding Structural Constituent Of Skin Epidermis
	Biological Process	Response To UV-B Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Keratinocyte Differentiation Keratinization	Cytoskeleton Organization Peptide Cross-linking Keratinocyte Differentiation Keratinization
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin
Diseases		None	Vohwinkel syndrome, including: Vohwinkel syndrome (VS); Vohwinkel syndrome with ichthyosis
GWAS		Asthma ( 31619474 ) Vitamin D levels ( 26704534 )	No GWAS studies recorded
Interacting Genes		10 interacting genes: ACD CRK CSTA DSP EVPL KRT1 LORICRIN POT1 SPRR3 UCHL5	8 interacting genes: CSTA EVPL IVL KRT1 PI3 SLC26A4-AS1 SPRR3 VIM
Entrez ID		3713	4014
HPRD ID		00931	01070
Ensembl ID		ENSG00000163207	ENSG00000203782
Uniprot IDs		P07476	P23490
PDB IDs		Not available	Not available
GO Terms Enriched among Interactors		Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Epidermal Cell Differentiation Keratinization Epidermis Development Telomere Assembly Epithelial Cell Differentiation Shelterin Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Wound Healing Telomere Capping Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Telomere Maintenance Regulation Of DNA Strand Elongation Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Organelle Organization Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Developmental Process Intermediate Filament Desmosome Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Structural Molecule Activity Response To Stress Negative Regulation Of Telomere Maintenance Cytoskeleton Organization Response To Wounding Protein Modification Process Regulation Of Telomere Maintenance Via Telomerase Endopeptidase Inhibitor Activity Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Ciliary Neurotrophic Factor Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Structural Constituent Of Skin Epidermis Positive Regulation Of DNA Metabolic Process Macromolecule Metabolic Process	Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Keratinization Epidermal Cell Differentiation Intermediate Filament Cytoskeleton Organization Intermediate Filament-based Process Epithelial Cell Differentiation Epidermis Development Intermediate Filament Endopeptidase Inhibitor Activity Intermediate Filament Cytoskeleton Protein Modification Process Structural Constituent Of Skin Epidermis Wound Healing Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Intermediate Filament Organization Copulation Extracellular Exosome Peptidase Inhibitor Activity Peptidase Inhibitor Complex Cell Differentiation Cytosol Regulation Of Antibacterial Peptide Production Keratin Filament Binding Structural Molecule Activity Tissue Development Lens Fiber Cell Development Response To Wounding Cellular Response To Muramyl Dipeptide Bergmann Glial Cell Differentiation Cellular Developmental Process Protein Metabolic Process Regulation Of Antimicrobial Humoral Response Complement Activation, Lectin Pathway Humoral Immune Response Protein Heterotetramerization