IVL and DNAH3

Data Source: HiPPIP (Novel)

		IVL	DNAH3
Name		involucrin	dynein axonemal heavy chain 3
Structure		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Centrosome Cytosol Nuclear Body Extracellular Exosome	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Dynein Complex Inner Dynein Arm Cell Projection 9+2 Motile Cilium
	Molecular Function	Protein Binding	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding
	Biological Process	Response To UV-B Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Keratinocyte Differentiation Keratinization	Cilium Movement Microtubule-based Movement Inner Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	None
GWAS		Asthma ( 31619474 ) Vitamin D levels ( 26704534 )	Diastolic blood pressure ( 27841878 ) Eosinophil count ( 32888494 ) Immune reponse to smallpox (secreted IL-10) ( 22610502 ) Plateletcrit ( 32888494 ) Resting-state electroencephalogram vigilance ( 29703947 ) Serum uric acid levels ( 29559957 ) Systolic blood pressure ( 27841878 )
Novel Interactors		2 novel interactors: DNAH3 IL6R	7 novel interactors: ERI2 IVL NPIPB3 REXO5 SOD1 TCIRG1 THUMPD1
Interacting Genes		10 interacting genes: ACD CRK CSTA DSP EVPL KRT1 LORICRIN POT1 SPRR3 UCHL5	None recorded
Entrez ID		3713	55567
HPRD ID		00931	04513
Ensembl ID		ENSG00000163207	ENSG00000158486
Uniprot IDs		P07476	A0A8V8TLI9 B4E1S1 Q8TD57
PDB IDs		Not available	8J07
GO Terms Enriched among Interactors		Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Epidermal Cell Differentiation Keratinization Epidermis Development Telomere Assembly Epithelial Cell Differentiation Shelterin Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Wound Healing Telomere Capping Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Telomere Maintenance Regulation Of DNA Strand Elongation Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Organelle Organization Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Developmental Process Intermediate Filament Desmosome Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Structural Molecule Activity Response To Stress Negative Regulation Of Telomere Maintenance Cytoskeleton Organization Response To Wounding Protein Modification Process Regulation Of Telomere Maintenance Via Telomerase Endopeptidase Inhibitor Activity Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Ciliary Neurotrophic Factor Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Structural Constituent Of Skin Epidermis Positive Regulation Of DNA Metabolic Process Macromolecule Metabolic Process	Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Dentin Mineralization Response To Silver Ion Exonuclease Activity Response To Antipsychotic Drug Action Potential Initiation Memory T Cell Activation