IVL and IL6R

Data Source: HiPPIP (Novel)

		IVL	IL6R
Name		involucrin	interleukin 6 receptor
Structure		No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytoplasm Centrosome Cytosol Nuclear Body Extracellular Exosome	Extracellular Region Extracellular Space Plasma Membrane Interleukin-6 Receptor Complex External Side Of Plasma Membrane Membrane Apical Plasma Membrane Receptor Complex Ciliary Neurotrophic Factor Receptor Complex
	Molecular Function	Protein Binding	Cytokine Receptor Activity Ciliary Neurotrophic Factor Receptor Activity Interleukin-6 Receptor Activity Interleukin-11 Receptor Activity Interleukin-6 Receptor Binding Protein Binding Enzyme Binding Interleukin-11 Binding Interleukin-6 Binding Protein Homodimerization Activity Ciliary Neurotrophic Factor Binding
	Biological Process	Response To UV-B Peptide Cross-linking Isopeptide Cross-linking Via N6-(L-isoglutamyl)-L-lysine Keratinocyte Differentiation Keratinization	Hepatic Immune Response Neutrophil Mediated Immunity Monocyte Chemotaxis Positive Regulation Of Leukocyte Chemotaxis Acute-phase Response Cell Surface Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Cell Population Proliferation Vascular Endothelial Growth Factor Production Cytokine-mediated Signaling Pathway Endocrine Pancreas Development Developmental Process Negative Regulation Of Interleukin-8 Production Positive Regulation Of Chemokine Production Positive Regulation Of Interleukin-6 Production Negative Regulation Of Collagen Biosynthetic Process Response To Cytokine Interleukin-11-mediated Signaling Pathway Positive Regulation Of MAPK Cascade Positive Regulation Of Osteoblast Differentiation Positive Regulation Of Smooth Muscle Cell Proliferation Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Interleukin-6-mediated Signaling Pathway Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Glomerular Mesangial Cell Proliferation T-helper 17 Cell Lineage Commitment Extrinsic Apoptotic Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Positive Regulation Of Platelet Aggregation
Pathways		Formation of the cornified envelope Differentiation of Keratinocytes in Interfollicular Epidermis in Mammalian Skin	Interleukin-6 signaling MAPK3 (ERK1) activation MAPK1 (ERK2) activation Interleukin-4 and Interleukin-13 signaling Transcriptional regulation of granulopoiesis Potential therapeutics for SARS
Drugs		None	Tocilizumab Sarilumab Satralizumab
GWAS		Asthma ( 31619474 ) Vitamin D levels ( 26704534 )	Abdominal aortic aneurysm ( 27899403 ) Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Albumin-globulin ratio ( 29403010 ) Allergic disease (asthma, hay fever or eczema) ( 29083406 ) Ankylosing spondylitis ( 23749187 ) Asthma ( 32296059 21907864 ) Atopic dermatitis ( 26482879 ) Atrial fibrillation ( 29892015 ) Blood protein levels ( 30072576 23696881 ) Blood protein levels in cardiovascular risk ( 28369058 ) C-reactive protein ( 19567438 18439548 ) C-reactive protein levels ( 30388399 29878111 29403010 21300955 33339817 ) Cerebrospinal fluid levels of Alzheimer's disease-related proteins ( 25340798 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Coronary artery disease ( 26343387 32469254 29212778 33020668 ) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975 ) Fibrinogen ( 20031577 23969696 ) Fibrinogen levels ( 28107422 26561523 ) Interleukin-6 levels ( 33517400 32473944 ) Interleukin-6 levels in HIV infection ( 33095540 ) Iron status biomarkers (iron levels) ( 33536631 ) Itch intensity from mosquito bite ( 28199695 ) Itch intensity from mosquito bite adjusted by bite size ( 28199695 ) Juvenile idiopathic arthritis (oligoarticular or rheumatoid factor-negative polyarticular) ( 23603761 ) Liver enzyme levels (alkaline phosphatase) ( 33972514 ) Mean corpuscular hemoglobin ( 32888494 ) Mean corpuscular volume ( 32888494 ) Mean platelet volume ( 32888494 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) Mosquito bite size ( 28199695 ) Myocardial infarction ( 26343387 33532862 ) Parental longevity (combined parental attained age, Martingale residuals) ( 29227965 ) Platelet count ( 32888494 ) Protein quantitative trait loci ( 18464913 ) Pulmonary function ( 17903307 ) Red cell distribution width ( 32888494 ) Response to anti-retroviral therapy (ddI/d4T) in HIV-1 infection (Grade 2 peripheral neuropathy) ( 24554482 ) Rheumatoid arthritis ( 24390342 23143596 30423114 ) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596 ) Serum alkaline phosphatase levels ( 33547301 ) Systemic lupus erythematosus ( 28714469 ) Type 1 diabetes ( 34127860 )
Interacting Genes		10 interacting genes: ACD CRK CSTA DSP EVPL KRT1 LORICRIN POT1 SPRR3 UCHL5	11 interacting genes: ADRB2 CNTF ERAP1 IL6 IL6ST MAGI1 SGTB SRC STAT3 WWP1 WWP2
Entrez ID		3713	3570
HPRD ID		00931	01000
Ensembl ID		ENSG00000163207	ENSG00000160712
Uniprot IDs		P07476	A0A087WTB5 A0N0L5 P08887
PDB IDs		Not available	1N26 1P9M 2ARW 5FUC 7DC8 8D82 8IOW 8QY5 8QY6
GO Terms Enriched among Interactors		Peptide Cross-linking Cornified Envelope Keratinocyte Differentiation Epidermal Cell Differentiation Keratinization Epidermis Development Telomere Assembly Epithelial Cell Differentiation Shelterin Complex Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere Positive Regulation Of Telomere Maintenance Nuclear Telomere Cap Complex Wound Healing Telomere Capping Intermediate Filament-based Process Intermediate Filament Cytoskeleton Organization Telomere Maintenance Regulation Of DNA Strand Elongation Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Organelle Organization Telomere Organization Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase RNA-templated DNA Biosynthetic Process Developmental Process Intermediate Filament Desmosome Telomeric DNA Binding Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Structural Molecule Activity Response To Stress Negative Regulation Of Telomere Maintenance Cytoskeleton Organization Response To Wounding Protein Modification Process Regulation Of Telomere Maintenance Via Telomerase Endopeptidase Inhibitor Activity Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Via Telomere Lengthening Ciliary Neurotrophic Factor Binding Positive Regulation Of DNA Strand Elongation Positive Regulation Of Telomeric D-loop Disassembly G-rich Single-stranded DNA Binding Structural Constituent Of Skin Epidermis Positive Regulation Of DNA Metabolic Process Macromolecule Metabolic Process	Interleukin-6 Receptor Binding Interleukin-6-mediated Signaling Pathway T-helper 17 Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via JAK-STAT T-helper Cell Lineage Commitment Cell Surface Receptor Signaling Pathway Via STAT CD4-positive, Alpha-beta T Cell Lineage Commitment Alpha-beta T Cell Lineage Commitment CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Regulation Of Notch Signaling Pathway Negative Regulation Of Primary MiRNA Processing T Cell Lineage Commitment Positive Regulation Of Vascular Endothelial Growth Factor Production Interleukin-6 Receptor Complex Cell Differentiation Ciliary Neurotrophic Factor-mediated Signaling Pathway Positive Regulation Of Notch Signaling Pathway Regulation Of Vascular Endothelial Growth Factor Production Ciliary Neurotrophic Factor Receptor Binding Interleukin-11-mediated Signaling Pathway Cytokine-mediated Signaling Pathway Negative Regulation Of MiRNA Processing Cellular Developmental Process Retinal Rod Cell Differentiation Positive Regulation Of Extracellular Matrix Disassembly Intestinal Epithelial Cell Development Inflammatory Response To Wounding Positive Regulation Of Platelet Aggregation Positive Regulation Of Developmental Process Regulation Of MiRNA Processing Developmental Process Camera-type Eye Photoreceptor Cell Differentiation Negative Regulation Of MiRNA-mediated Gene Silencing Negative Regulation Of Post-transcriptional Gene Silencing By Regulatory NcRNA Regulation Of Regulatory NcRNA Processing Protein Tyrosine Kinase Activator Activity Columnar/cuboidal Epithelial Cell Development Negative Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Eye Photoreceptor Cell Differentiation Positive Regulation Of Homotypic Cell-cell Adhesion Negative Regulation Of Anoikis Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Phosphate Metabolic Process Photoreceptor Cell Differentiation Symbiont Entry Into Host Cell Positive Regulation Of Cell-cell Adhesion Regulation Of Extracellular Matrix Disassembly Bone Resorption