PRTN3 and F2R

Number of citations of the paper that reports this interaction (PMID 10978167)
15

Data Source:
HPRD (in vitro)

		PRTN3	F2R
Gene Name		proteinase 3	coagulation factor II (thrombin) receptor
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Region Early Endosome Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Caveola Platelet Dense Tubular Network Neuromuscular Junction Postsynaptic Membrane
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Enzyme Binding	G-protein Alpha-subunit Binding G-protein Coupled Receptor Activity Receptor Binding Protein Binding Thrombin Receptor Activity G-protein Beta-subunit Binding
	Biological Process	Proteolysis Blood Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Negative Regulation Of Phagocytosis Mature Conventional Dendritic Cell Differentiation	Activation Of MAPKK Activity Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Negative Regulation Of Glomerular Filtration Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Inflammatory Response G-protein Coupled Receptor Signaling Pathway Phospholipase C-activating G-protein Coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Protein Kinase C-activating G-protein Coupled Receptor Signaling Pathway Tyrosine Phosphorylation Of STAT Protein STAT Protein Import Into Nucleus Establishment Of Synaptic Specificity At Neuromuscular Junction Blood Coagulation Positive Regulation Of Cell Proliferation Negative Regulation Of Cell Proliferation Response To Wounding Anatomical Structure Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Platelet Activation Regulation Of Blood Coagulation Positive Regulation Of Blood Coagulation Positive Regulation Of Cell Migration Response To Lipopolysaccharide Regulation Of Interleukin-1 Beta Production Positive Regulation Of Collagen Biosynthetic Process Positive Regulation Of Rho Protein Signal Transduction Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of MAPK Cascade Negative Regulation Of Neuron Apoptotic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Vasoconstriction Positive Regulation Of Smooth Muscle Contraction Positive Regulation Of JAK-STAT Cascade Homeostasis Of Number Of Cells Within A Tissue Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Cytosolic Calcium Ion Concentration Involved In Phospholipase C-activating G-protein Coupled Signaling Pathway Positive Regulation Of Calcium Ion Transport Regulation Of Sensory Perception Of Pain Platelet Dense Granule Organization Positive Regulation Of ERK1 And ERK2 Cascade Thrombin Receptor Signaling Pathway Negative Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Interleukin-8 Secretion Positive Regulation Of Interleukin-6 Secretion
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade)	Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) G alpha (q) signalling events Signaling by GPCR Class A/1 (Rhodopsin-like receptors) Metabolic disorders of biological oxidation enzymes GPCR ligand binding Formation of Fibrin Clot (Clotting Cascade) Common Pathway G alpha (q) signalling events Thrombin signalling through proteinase activated receptors (PARs) GPCR downstream signaling Peptide ligand-binding receptors Gastrin-CREB signalling pathway via PKC and MAPK Platelet activation, signaling and aggregation
Drugs			Streptokinase
Diseases
GWAS			Mean platelet volume ( 22139419) Platelet counts ( 22139419)
Protein-Protein Interactions		13 interactors: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF	17 interactors: ATP13A2 CAPN1 CHRD CTSG ELANE F2 GNA12 GNA13 GNA15 GNAI2 GNAT1 GPRASP1 ITGAV PDCD6IP PLG PRTN3 SNX1
Entrez ID		5657	2149
HPRD ID		01512	01763
Ensembl ID		ENSG00000196415	ENSG00000181104
Uniprot IDs		P24158	P25116 Q2TNB2
PDB IDs		1FUJ	1NRN 1NRO 1NRP 1NRQ 1NRR 3BEF 3HKI 3HKJ 3LU9 3VW7
Enriched GO Terms of Interacting Partners?		Response To Other Organism Inflammatory Response Response To Biotic Stimulus Positive Regulation Of Interleukin-8 Production Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Proteolysis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Interleukin-6 Production Response To External Stimulus Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Bacterium Regulation Of Cytokine Production Negative Regulation Of Protein Secretion Regulation Of Interleukin-6 Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Transport Cell Activation Response To Stress Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Sequestering Of Triglyceride Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lipopolysaccharide Positive Regulation Of Transcription Factor Import Into Nucleus Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Secretion By Cell Regulation Of Phosphorylation Negative Regulation Of Secretion Positive Regulation Of Phagocytosis Negative Regulation Of Protein Transport Response To Lipid Negative Regulation Of Cellular Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Immune Response Regulation Of Chemokine Production Negative Regulation Of Protein Metabolic Process Regulation Of Renin Secretion Into Blood Stream Immune System Process	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Platelet Activation Response To Wounding Adenylate Cyclase-modulating G-protein Coupled Receptor Signaling Pathway G-protein Coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Extracellular Matrix Disassembly Positive Regulation Of Cell Proliferation Regulation Of Cell Proliferation Extracellular Matrix Organization Extracellular Structure Organization Cell Activation Killing By Host Of Symbiont Cells Leukocyte Migration Receptor Metabolic Process Negative Regulation Of Fibrinolysis Response To Stress Receptor Catabolic Process Regulation Of Fibrinolysis Proteolysis G-protein Coupled Acetylcholine Receptor Signaling Pathway Cellular Calcium Ion Homeostasis Calcium Ion Homeostasis Regulation Of Locomotion Cellular Homeostasis Neutrophil Mediated Immunity Killing Of Cells Of Other Organism Cellular Metal Ion Homeostasis Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Regulation Of Cell Shape Fibrinolysis Cellular Cation Homeostasis Positive Regulation Of Blood Coagulation Cellular Ion Homeostasis Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Interaction With Symbiont Leukocyte Mediated Cytotoxicity Cytosolic Calcium Ion Homeostasis Metal Ion Homeostasis Regulation Of Signal Transduction Positive Regulation Of Coagulation Response To Fungus Regulation Of Protein Metabolic Process Cellular Chemical Homeostasis Response To Stimulus Positive Regulation Of Wound Healing Ion Homeostasis
Tagcloud ?		aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a	agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
Tagcloud (Difference) ?		aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a	agt card4 casp1 csf2 csf3 curcuma icam1 ifng ikbkb ikbke il10 il1a il1b il8 impressive irak2 longa map3k1 nfkb1 nfkb2 nfkbia ppm1a raf1 relb ticam1 ticam2 tnfalphaip3 tnfrsf7 tnfsf10
Tagcloud (Intersection) ?