PRTN3 and SERPINB13

Number of citations of the paper that reports this interaction (PMID 10512713)
4

Data Source:
HPRD (in vitro)

		PRTN3	SERPINB13
Gene Name		proteinase 3	serpin peptidase inhibitor, clade B (ovalbumin), member 13
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Space Cytoplasm Extracellular Vesicular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Enzyme Binding	Serine-type Endopeptidase Inhibitor Activity
	Biological Process	Proteolysis Blood Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Negative Regulation Of Phagocytosis Mature Conventional Dendritic Cell Differentiation	Response To UV Negative Regulation Of Endopeptidase Activity Regulation Of Proteolysis
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS
Protein-Protein Interactions		13 interactors: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF	8 interactors: CTSB CTSG CTSK CTSL ELANE PLG PRSS1 PRTN3
Entrez ID		5657	5275
HPRD ID		01512	05118
Ensembl ID		ENSG00000196415	ENSG00000197641
Uniprot IDs		P24158	Q9UIV8
PDB IDs		1FUJ
Enriched GO Terms of Interacting Partners?		Response To Other Organism Inflammatory Response Response To Biotic Stimulus Positive Regulation Of Interleukin-8 Production Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Proteolysis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Interleukin-6 Production Response To External Stimulus Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Bacterium Regulation Of Cytokine Production Negative Regulation Of Protein Secretion Regulation Of Interleukin-6 Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Transport Cell Activation Response To Stress Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Sequestering Of Triglyceride Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lipopolysaccharide Positive Regulation Of Transcription Factor Import Into Nucleus Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Secretion By Cell Regulation Of Phosphorylation Negative Regulation Of Secretion Positive Regulation Of Phagocytosis Negative Regulation Of Protein Transport Response To Lipid Negative Regulation Of Cellular Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Immune Response Regulation Of Chemokine Production Negative Regulation Of Protein Metabolic Process Regulation Of Renin Secretion Into Blood Stream Immune System Process	Extracellular Matrix Disassembly Extracellular Matrix Organization Extracellular Structure Organization Collagen Catabolic Process Collagen Metabolic Process Multicellular Organismal Macromolecule Metabolic Process Multicellular Organismal Metabolic Process Proteolysis Immune System Process Protein Catabolic Process Positive Regulation Of Immune Response Killing By Host Of Symbiont Cells Regulation Of Immune Response Positive Regulation Of Immune System Process Catabolic Process Cellular Response To Thyroid Hormone Stimulus Toll-like Receptor Signaling Pathway Protein Metabolic Process Pattern Recognition Receptor Signaling Pathway Innate Immune Response-activating Signal Transduction Response To Stress Response To Thyroid Hormone Activation Of Innate Immune Response Proteolysis Involved In Cellular Protein Catabolic Process Neutrophil Mediated Immunity Cellular Protein Catabolic Process Immune Response Regulation Of Immune System Process Positive Regulation Of Innate Immune Response Defense Response Killing Of Cells Of Other Organism Negative Regulation Of Growth Of Symbiont In Host Defense Response To Fungus Interaction With Symbiont Leukocyte Mediated Cytotoxicity Regulation Of Innate Immune Response Response To Fungus Cellular Macromolecule Catabolic Process Immune Response-regulating Signaling Pathway Tissue Remodeling Neutrophil Mediated Killing Of Gram-positive Bacterium Neutrophil Mediated Killing Of Fungus Macrophage Apoptotic Process Mononuclear Cell Migration Negative Regulation Of Cell-cell Adhesion Mediated By Cadherin Positive Regulation Of Fibrinolysis Placenta Development Negative Regulation Of Chemokine Biosynthetic Process Negative Regulation Of Interleukin-8 Biosynthetic Process Defense Response To Bacterium
Tagcloud ?		aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a	abs accelerated autoantibodies autoimmune cd3 clade coadministration discovered fashion homeostasis humoral hypo immunity immunological islet limiting mab maintain nod osmotic ova prone protease proteases protecting reagent suboptimal
Tagcloud (Difference) ?		aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a	abs accelerated autoantibodies autoimmune cd3 clade coadministration discovered fashion homeostasis humoral hypo immunity immunological islet limiting mab maintain nod osmotic ova prone protease proteases protecting reagent suboptimal
Tagcloud (Intersection) ?