PRTN3 and IL32

Number of citations of the paper that reports this interaction (PMID 16488976)
24

Data Source:
HPRD (in vitro)

		PRTN3	IL32
Gene Name		proteinase 3	interleukin 32
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Cytosol Plasma Membrane Extracellular Matrix Extracellular Vesicular Exosome	Extracellular Space Membrane
	Molecular Function	Serine-type Endopeptidase Activity Serine-type Peptidase Activity Enzyme Binding	Cytokine Activity Protein Binding
	Biological Process	Proteolysis Blood Coagulation Positive Regulation Of Cell Proliferation Collagen Catabolic Process Negative Regulation Of Phagocytosis Mature Conventional Dendritic Cell Differentiation	Defense Response Immune Response Cell Adhesion
Pathways		Common Pathway Formation of Fibrin Clot (Clotting Cascade)
Drugs
Diseases
GWAS			HIV-1 susceptibility ( 22174851)
Protein-Protein Interactions		13 interactors: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF	10 interactors: C1QB HSPA8 KPNA5 NDN NQO2 PRTN3 RPL4 SNRNP70 TUT1 ZFPM2
Entrez ID		5657	9235
HPRD ID		01512	09346
Ensembl ID		ENSG00000196415	ENSG00000008517
Uniprot IDs		P24158	C6GKH1 G3LU47 P24001
PDB IDs		1FUJ
Enriched GO Terms of Interacting Partners?		Response To Other Organism Inflammatory Response Response To Biotic Stimulus Positive Regulation Of Interleukin-8 Production Defense Response Response To Lipopolysaccharide Response To Molecule Of Bacterial Origin Regulation Of Protein Metabolic Process Positive Regulation Of Cytokine Production Regulation Of Proteolysis Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Regulation Of Endopeptidase Activity Regulation Of Peptidase Activity Positive Regulation Of Interleukin-6 Production Response To External Stimulus Immune Response Regulation Of I-kappaB Kinase/NF-kappaB Signaling Positive Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Cellular Protein Metabolic Process Response To Bacterium Regulation Of Cytokine Production Negative Regulation Of Protein Secretion Regulation Of Interleukin-6 Production Positive Regulation Of NF-kappaB Transcription Factor Activity Leukocyte Cell-cell Adhesion Positive Regulation Of Protein Transport Cell Activation Response To Stress Positive Regulation Of Calcidiol 1-monooxygenase Activity Positive Regulation Of Vitamin D Biosynthetic Process Sequestering Of Triglyceride Positive Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Cellular Response To Lipopolysaccharide Positive Regulation Of Transcription Factor Import Into Nucleus Cellular Response To Molecule Of Bacterial Origin Negative Regulation Of Secretion By Cell Regulation Of Phosphorylation Negative Regulation Of Secretion Positive Regulation Of Phagocytosis Negative Regulation Of Protein Transport Response To Lipid Negative Regulation Of Cellular Metabolic Process Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Immune Response Regulation Of Chemokine Production Negative Regulation Of Protein Metabolic Process Regulation Of Renin Secretion Into Blood Stream Immune System Process	Positive Regulation Of MRNA Splicing, Via Spliceosome MRNA Metabolic Process Positive Regulation Of RNA Splicing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Fibril Organization Regulation Of MRNA Processing MRNA Processing Regulation Of RNA Splicing RNA Metabolic Process Right Ventricular Cardiac Muscle Tissue Morphogenesis Gene Expression Regulation Of Fibril Organization RNA Processing Negative Regulation Of Female Gonad Development Clathrin Coat Disassembly Cellular Protein Complex Disassembly Mature Conventional Dendritic Cell Differentiation Protein Complex Disassembly Gonadal Mesoderm Development MRNA Splicing, Via Spliceosome RNA Splicing, Via Transesterification Reactions Positive Regulation Of Male Gonad Development Regulation Of Female Gonad Development Negative Regulation Of Phagocytosis Nucleobase-containing Compound Metabolic Process
Tagcloud ?		aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a	attempt basal cancers candidate datasets define defining designated differential geo hyperplastic incredible luminal mb231 mcf7 mda microarrays omnibus past progesterone public publically search suitable tma tmas tnbc triple validation
Tagcloud (Difference) ?		aspartic cathepsin cited2 colonies compromised elastase elementbinding embryogenesis eosinophil fetal gata2 glutamic kit lef lethality lin lineages livers lymphoid manifesting modulator mpo notch1 peroxidase reconstitution sca transactivators uncovers wnt5a	attempt basal cancers candidate datasets define defining designated differential geo hyperplastic incredible luminal mb231 mcf7 mda microarrays omnibus past progesterone public publically search suitable tma tmas tnbc triple validation
Tagcloud (Intersection) ?