PRTN3

Name	proteinase 3
Structure
Interactors	13 interactors: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Matrix Azurophil Granule Lumen Plasma Membrane Raft Membrane Raft Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Enzyme Binding
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Population Proliferation Antimicrobial Humoral Response Collagen Catabolic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation
Pathways	Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides
Drugs	Elafin
GWAS	Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 32888494 ) Blood protein levels ( 30072576 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) White blood cell count (basophil) ( 27863252 )
Entrez ID	5657
HPRD ID	01512
Ensembl ID	ENSG00000196415
Uniprot IDs	P24158
PDB IDs	1FUJ
GO Terms Enriched among Interactors ?	Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Production Inflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Establishment Of Protein Localization Defense Response Positive Regulation Of Establishment Of Protein Localization Regulation Of Interleukin-6 Production Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cell Activation Positive Regulation Of Chemokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Humoral Immune Response Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Chemokine Production Positive Regulation Of Protein Transport Positive Regulation Of Transport Regulation Of Protein Secretion Immune System Process Negative Regulation Of Apoptotic Process Protease Binding Negative Regulation Of MiRNA Transcription Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Renin Secretion Into Blood Stream Regulation Of Secretion By Cell Regulation Of Immune Response Response To Lipopolysaccharide Myeloid Leukocyte Activation Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Vasculature Development Response To Molecule Of Bacterial Origin Regulation Of Secretion Regulation Of Protein Metabolic Process