PRTN3 and SERPINB1

Number of citations: 0 (PubMedID 12114510)
Data Source: HPRD (in vitro)

		PRTN3	SERPINB1
Name		proteinase 3	serpin family B member 1
Structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytosol Plasma Membrane Membrane Extracellular Matrix Azurophil Granule Lumen Plasma Membrane Raft Membrane Raft Extracellular Exosome	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Early Endosome Membrane Extracellular Matrix Secretory Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cytolytic Granule Extracellular Exosome
	Molecular Function	Serine-type Endopeptidase Activity Signaling Receptor Binding Protein Binding Peptidase Activity Serine-type Peptidase Activity Hydrolase Activity Enzyme Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Proteolysis Membrane Protein Ectodomain Proteolysis Positive Regulation Of Cell Population Proliferation Antimicrobial Humoral Response Collagen Catabolic Process Positive Regulation Of GTPase Activity Cell-cell Junction Maintenance Negative Regulation Of Phagocytosis Neutrophil Extravasation Mature Conventional Dendritic Cell Differentiation	Negative Regulation Of Endopeptidase Activity Negative Regulation Of Cell Migration Negative Regulation Of Interleukin-1 Beta Production Type B Pancreatic Cell Proliferation Regulation Of Protein Metabolic Process
Pathways		Common Pathway of Fibrin Clot Formation Other interleukin signaling Neutrophil degranulation Antimicrobial peptides	Neutrophil degranulation CASP4 inflammasome assembly
Drugs		Elafin	None
GWAS		Antineutrophil cytoplasmic antibody-associated vasculitis ( 28029757 ) Basophil count ( 32888494 ) Basophil percentage of granulocytes ( 27863252 ) Basophil percentage of white cells ( 27863252 32888494 ) Blood protein levels ( 30072576 ) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223 ) Monocyte count ( 32888494 ) Monocyte percentage of white cells ( 27863252 32888494 ) White blood cell count (basophil) ( 27863252 )	BMI at 5 years old ( 31575865 ) Cerebrospinal fluid AB1-42 levels ( 28247064 )
Interacting Genes		13 interacting genes: CAMP ELN F2R F2RL1 IL1B IL32 ITGB2 RELA SERPINA1 SERPINB1 SERPINB13 SMAD3 TNF	4 interacting genes: CDC42 ELANE PRTN3 XPO1
Entrez ID		5657	1992
HPRD ID		01512	00555
Ensembl ID		ENSG00000196415	ENSG00000021355
Uniprot IDs		P24158	P30740 V9HWH1
PDB IDs		1FUJ	4GA7
GO Terms Enriched among Interactors		Regulation Of Interleukin-1 Beta Production Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-8 Production Regulation Of Interleukin-8 Production Positive Regulation Of Cytokine Production Regulation Of Cytokine Production Positive Regulation Of Interleukin-1 Beta Production Inflammatory Response Positive Regulation Of Interleukin-1 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Regulation Of Establishment Of Protein Localization Defense Response Positive Regulation Of Establishment Of Protein Localization Regulation Of Interleukin-6 Production Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Nitric Oxide Metabolic Process Cell Activation Positive Regulation Of Chemokine Production Positive Regulation Of Multicellular Organismal Process Regulation Of Protein Transport Positive Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Humoral Immune Response Positive Regulation Of Gene Expression Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Chemokine Production Positive Regulation Of Protein Transport Positive Regulation Of Transport Regulation Of Protein Secretion Immune System Process Negative Regulation Of Apoptotic Process Protease Binding Negative Regulation Of MiRNA Transcription Negative Regulation Of Programmed Cell Death Regulation Of Protein Localization Regulation Of Renin Secretion Into Blood Stream Regulation Of Secretion By Cell Regulation Of Immune Response Response To Lipopolysaccharide Myeloid Leukocyte Activation Regulation Of Programmed Cell Death Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Angiogenesis Regulation Of Wound Healing Regulation Of Vasculature Development Response To Molecule Of Bacterial Origin Regulation Of Secretion Regulation Of Protein Metabolic Process	Leukocyte Migration Cell-cell Junction Organization Positive Regulation Of Cell Population Proliferation Endothelin Receptor Signaling Pathway Involved In Heart Process Cell Migration GBD Domain Binding Storage Vacuole Phagocytic Vesicle Myeloid Leukocyte Differentiation Biosynthetic Process Of Antibacterial Peptides Active Against Gram-negative Bacteria Azurophil Granule Lumen Antibacterial Peptide Biosynthetic Process Neutrophil-mediated Killing Of Fungus Serine-type Peptidase Activity Serine-type Endopeptidase Activity Cellular Response To Triglyceride Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Cell Motility Response To Triglyceride Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Organelle Localization Myeloid Cell Differentiation Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neutrophil-mediated Killing Of Gram-negative Bacterium Mature Conventional Dendritic Cell Differentiation Neutrophil Extravasation Annulate Lamellae Cellular Response To Salt Ribosomal Small Subunit Export From Nucleus Ribosomal Large Subunit Export From Nucleus Leading Edge Membrane Thioesterase Binding Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Neuron Fate Determination Mononuclear Cell Differentiation Establishment Of Golgi Localization Golgi Transport Complex Regulation Of Endocytosis Positive Regulation Of Leukocyte Tethering Or Rolling Neutrophil-mediated Killing Of Bacterium Positive Regulation Of Catalytic Activity Ribosomal Subunit Export From Nucleus Leukocyte Differentiation Positive Regulation Of Pseudopodium Assembly Endothelin Receptor Signaling Pathway Regulation Of Transport Hydrolase Activity