ITGAX and FCER2

Number of citations of the paper that reports this interaction (PMID 7621072)
20

Data Source:
HPRD (in vivo)

		ITGAX	FCER2
Gene Name		integrin, alpha X (complement component 3 receptor 4 subunit)	Fc fragment of IgE, low affinity II, receptor for (CD23)
Image
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane	Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Extracellular Vesicular Exosome
	Molecular Function	Receptor Activity Protein Binding Metal Ion Binding	Integrin Binding IgE Binding Carbohydrate Binding Metal Ion Binding
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Organ Morphogenesis Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Leukocyte Migration	Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Notch Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Killing Of Cells Of Other Organism Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process
Pathways		ECM proteoglycans Integrin cell surface interactions Cell surface interactions at the vascular wall	Signaling by NOTCH2 Signaling by NOTCH NOTCH2 intracellular domain regulates transcription
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		4 interactors: C3 FCER2 ITGB2 JAM3	5 interactors: ATF7 CR2 FYN ITGAX ITGB2
Entrez ID		3687	2208
HPRD ID		01051	01049
Ensembl ID		ENSG00000140678	ENSG00000104921
Uniprot IDs		H3BN02 P20702 Q8TES5	K3W4U1 P06734
PDB IDs		1N3Y 2LUV 3K6S 3K71 3K72	1HLI 1KJE 1T8C 1T8D 2H2R 2H2T 4EZM 4G96 4G9A 4GI0 4GJ0 4GJX 4GK1 4GKO 4J6J 4J6K 4J6L 4J6M 4J6N 4J6P
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Humoral Immune Response Regulation Of Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Positive Regulation Of Angiogenesis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Adaptive Immune Response Cell-matrix Adhesion Positive Regulation Of Type IIa Hypersensitivity Regulation Of Adaptive Immune Response Cell-substrate Adhesion Regulation Of Angiogenesis Leukocyte Migration Positive Regulation Of Activation Of Membrane Attack Complex Immune Response Defense Response Adaptive Immune Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Hypersensitivity Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Myeloid Progenitor Cell Differentiation Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Regulation Of Apoptotic Cell Clearance Blood Coagulation Hemostasis Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Neutrophil Homeostasis Single Organismal Cell-cell Adhesion Immune System Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process Signaling Regulation Of Body Fluid Levels Cell Communication Wound Healing Heterotypic Cell-cell Adhesion	Lymphocyte Proliferation Mononuclear Cell Proliferation Leukocyte Proliferation Activated T Cell Proliferation Leukocyte Migration Heterotypic Cell-cell Adhesion Lymphocyte Activation Defense Response Blood Coagulation T Cell Proliferation Hemostasis Immune Response-regulating Signaling Pathway Leukocyte Activation Single Organismal Cell-cell Adhesion Regulation Of Body Fluid Levels Wound Healing Positive Regulation Of Immune Response Cell Activation Integrin-mediated Signaling Pathway Response To Wounding Cell Proliferation Immune System Process Innate Immune Response Cell Migration Regulation Of Cell Shape Regulation Of Immune Response Cell Motility Positive Regulation Of Immune System Process Complement Receptor Mediated Signaling Pathway Cell Adhesion T Cell Aggregation T Cell Activation Lymphocyte Aggregation Leukocyte Aggregation Locomotion Cell Surface Receptor Signaling Pathway Immune Response-activating Cell Surface Receptor Signaling Pathway Immune Response Regulation Of Immune System Process Leukocyte Cell-cell Adhesion Homotypic Cell-cell Adhesion Detection Of Mechanical Stimulus Involved In Sensory Perception Of Pain Response To Stress Movement Of Cell Or Subcellular Component Cellular Response To Platelet-derived Growth Factor Stimulus Extracellular Matrix Organization Extracellular Structure Organization Immune Response-regulating Cell Surface Receptor Signaling Pathway Response To Platelet-derived Growth Factor Leukocyte Migration Involved In Inflammatory Response
Tagcloud ?			adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd pvrl2 seq slc2a14 snca tcl1b variations
Tagcloud (Difference) ?			adarb2 asymptomatic carriers carrying ceacam6 cntnap2 col19a1 commonest consider def4 dopaminergic draxin functionally g2019s hbg1 idiopathic initiating lrrk2 merit ncapg2 never parkinson pd pvrl2 seq slc2a14 snca tcl1b variations
Tagcloud (Intersection) ?