ITGAX and C3

Number of citations of the paper that reports this interaction (PubMedID 7512600)
0

Data Source:
HPRD (in vitro, in vivo)

		ITGAX	C3
Description		integrin subunit alpha X	complement C3
Image
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Extracellular Region Classical-complement-pathway C3/C5 Convertase Complex Extracellular Space Endoplasmic Reticulum Lumen Plasma Membrane Cell Surface Protein-containing Complex Secretory Granule Lumen Azurophil Granule Lumen Extracellular Exosome Blood Microparticle Symbiont Cell Surface
	Molecular Function	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding	Antigen Binding Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity C5L2 Anaphylatoxin Chemotactic Receptor Binding Receptor Ligand Activity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Positive Regulation Of Angiogenesis Defense Response To Virus Cell-cell Adhesion Positive Regulation Of Endothelial Tube Morphogenesis	Positive Regulation Of Type IIa Hypersensitivity Complement Activation, Lectin Pathway Activation Of Membrane Attack Complex Positive Regulation Of Protein Phosphorylation Positive Regulation Of Activation Of Membrane Attack Complex Immune System Process Complement Receptor Mediated Signaling Pathway Lipid Metabolic Process Fatty Acid Metabolic Process Inflammatory Response Immune Response Complement Activation Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Signal Transduction G Protein-coupled Receptor Signaling Pathway Opsonization Response To Bacterium Positive Regulation Of Vascular Endothelial Growth Factor Production Positive Regulation Of D-glucose Transmembrane Transport Regulation Of Triglyceride Biosynthetic Process Positive Regulation Of Lipid Storage Neuron Remodeling Leukocyte Chemotaxis Killing Of Cells Of Another Organism Oviduct Epithelium Development B Cell Activation Innate Immune Response Positive Regulation Of G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Phagocytosis Protein Maturation Positive Regulation Of Phagocytosis, Engulfment Amyloid-beta Clearance Complement-dependent Cytotoxicity Complement-mediated Synapse Pruning Vertebrate Eye-specific Patterning Complement Activation, GZMK Pathway Positive Regulation Of Apoptotic Cell Clearance
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Alternative complement activation Activation of C3 and C5 Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Peptide ligand-binding receptors Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) G alpha (i) signalling events Neutrophil degranulation Post-translational protein phosphorylation Purinergic signaling in leishmaniasis infection Regulation of Complement cascade
Drugs		Efalizumab	Human immunoglobulin G Zinc S-Hydroxycysteine Mirococept Copper Zinc acetate Zinc chloride Zinc sulfate, unspecified form Pegcetacoplan
Diseases			Macular degeneration, including: Age-related macular degeneration (ARMD); Patterned dystrophy of retinal pigment epithelium (PDREP); Retinal macular dystrophy 2 (MCDR2); X-linked atrophic macular degeneration (MDXLA) Classic complement pathway component defects, including the following eight diseases: C1q alpha-chain deficiency; C1q beta-chain deficiency; C1q gamma-chain deficiency; C1r deficiency; C1s deficiency; C2 deficiency; C3 deficiency; C4 deficiency
GWAS		IgA nephropathy ( 25305756) Post bronchodilator FEV1 ( 26634245) Systemic lupus erythematosus ( 18204098)	Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 20861866 21665990 23455636 20385819) Age-related macular degeneration (choroidal neovascularisation) ( 22705344) Age-related macular degeneration (geographic atrophy) ( 22705344) Blood protein levels ( 30072576) Complement C3 and C4 levels ( 23028341) Complement C3 levels ( 33941608) Disease progression in age-related macular degeneration ( 29346644) Early age-related macular degeneration ( 32843070) Liver enzyme levels (gamma-glutamyl transferase) ( 33972514) Lymphocyte count ( 32888494) Monocyte count ( 32888494 27863252) Monocyte percentage of white cells ( 32888494) Triglycerides ( 24097068) White blood cell count ( 32888494)
Interacting Genes		5 interacting genes: C3 FCER2 ITGB2 JAM3 MIA3	37 interacting genes: ABL1 AGR2 ATG16L1 C2 C3AR1 C5 C5AR2 CD46 CFB CFH CFHR3 CFHR4 CFHR5 CFI CFP CPN1 CR1 CR2 CTSG EFEMP2 GC GOLGA6L9 HMGB1 HSP90AA1 ITGAM ITGAX ITGB2 KRT31 KRTAP10-8 LAMA1 LRP1 MASP1 OLFM4 PAPPA PLEKHF2 TGM2 VSIG4
Entrez ID		3687	718
HPRD ID		01051	00400
Ensembl ID		ENSG00000140678	ENSG00000125730
Uniprot IDs		H3BN02 P20702	B4DR57 P01024 V9HWA9
PDB IDs		1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4	1C3D 1GHQ 1W2S 2A73 2A74 2GOX 2I07 2ICE 2ICF 2NOJ 2QKI 2WII 2WIN 2WY7 2WY8 2XQW 2XWB 2XWJ 3D5R 3D5S 3G6J 3L3O 3L5N 3NMS 3OED 3OHX 3OXU 3RJ3 3T4A 4HW5 4HWJ 4I6O 4M76 4ONT 4ZH1 5FO7 5FO8 5FO9 5FOA 5FOB 5NBQ 5O32 5O35 6EHG 6RMT 6RMU 6RUR 6RUV 6S0B 6YO6 7AKK 7BAG 7NOZ 7PI6 7QIV 7TV9 7UE9 7ZGK 8ENU 8EOK 8HK2 8I9L 8OQ3 8OVB 8UH2 8UIN
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Regulation Of Immune System Process Integrin Binding Positive Regulation Of Humoral Immune Response Leukocyte Migration Involved In Inflammatory Response Leukocyte Migration Amyloid-beta Clearance Cargo Receptor Activity Positive Regulation Of Immune Effector Process Cell Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Heterotypic Cell-cell Adhesion Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Motility Regulation Of Humoral Immune Response Macrophage Activation Endothelial Cell Migration C5L2 Anaphylatoxin Chemotactic Receptor Binding Low-affinity IgE Receptor Activity Granulocyte Migration Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Leukocyte Activation Cell-matrix Adhesion Positive Regulation Of Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response B Cell Antigen Processing And Presentation Myeloid Leukocyte Activation Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Myeloid Leukocyte Migration Integrin AlphaL-beta2 Complex Leukocyte Chemotaxis Immune System Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Vertebrate Eye-specific Patterning Fc Receptor-mediated Immune Complex Endocytosis ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-substrate Adhesion Negative Regulation Of Integrin Activation Regulation Of Cell Adhesion Receptor-mediated Endocytosis	Complement Activation Activation Of Immune Response Positive Regulation Of Immune Response Complement Activation, Alternative Pathway Immune Effector Process Complement Component C3b Binding Regulation Of Immune Response Humoral Immune Response Positive Regulation Of Immune System Process Extracellular Space Regulation Of Immune System Process Immune System Process Regulation Of Complement Activation Defense Response Response To Other Organism Response To External Biotic Stimulus Regulation Of Humoral Immune Response Immune Response Defense Response To Symbiont Defense Response To Other Organism Innate Immune Response Complement Receptor Mediated Signaling Pathway Negative Regulation Of Complement Activation Regulation Of Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Extracellular Region Complement Receptor Activity Positive Regulation Of Cell Adhesion Response To Stress Extracellular Exosome Phagocytosis Symbiont Cell Surface Regulation Of Cell Adhesion Negative Regulation Of Immune System Process Killing Of Cells Of Another Organism Complement Binding Negative Regulation Of Complement Activation, Classical Pathway Regulation Of Apoptotic Cell Clearance Negative Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Activation Of Membrane Attack Complex Complement Activation, Lectin Pathway Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Cell Killing Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Peptidase Activity Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Negative Regulation Of Immune Response Serine-type Peptidase Activity
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