ITGAX and MIA3

Number of citations of the paper that reports this interaction (PubMedID 17726152)
0

Data Source:
BioGRID (pull down)

		ITGAX	MIA3
Description		integrin subunit alpha X	MIA SH3 domain ER export factor 3
Image
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Membrane Endoplasmic Reticulum Exit Site
	Molecular Function	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding	Protein Binding Cargo Receptor Activity
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Positive Regulation Of Angiogenesis Defense Response To Virus Cell-cell Adhesion Positive Regulation Of Endothelial Tube Morphogenesis	Cell Migration Involved In Sprouting Angiogenesis Positive Regulation Of Leukocyte Migration Exocytosis Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Endoplasmic Reticulum Organization Negative Regulation Of Cell Adhesion Protein Secretion Protein Transport Vesicle-mediated Transport Negative Regulation Of Cell Migration Vesicle Cargo Loading Wound Healing Lipoprotein Transport System Development Protein Localization To Endoplasmic Reticulum Exit Site COPII-coated Vesicle Cargo Loading Cellular Response To Oxidised Low-density Lipoprotein Particle Stimulus Negative Regulation Of Leukocyte Cell-cell Adhesion Negative Regulation Of Lymphocyte Migration
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Cargo concentration in the ER Post-translational protein phosphorylation
Drugs		Efalizumab
Diseases
GWAS		IgA nephropathy ( 25305756) Post bronchodilator FEV1 ( 26634245) Systemic lupus erythematosus ( 18204098)	Coronary artery disease ( 26343387 29212778 32469254 33020668) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Coronary heart disease ( 17634449 21378990) Myocardial infarction ( 26343387 33532862) Myocardial infarction (early onset) ( 19198609)
Interacting Genes		5 interacting genes: C3 FCER2 ITGB2 JAM3 MIA3	17 interacting genes: CACNA1A CEP55 CLIC3 COL7A1 FXR2 HOMER3 HSD17B14 ITGAX LENG8 MTNR1B NCK2 PRDM14 SEC16A SEC23A SEC24C TRIM27 UBC
Entrez ID		3687	375056
HPRD ID		01051	18918
Ensembl ID		ENSG00000140678	ENSG00000154305
Uniprot IDs		H3BN02 P20702	Q5JRA6
PDB IDs		1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4	5KYN 5KYU 5KYW 7R3M
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Immune System Process Regulation Of Immune System Process Integrin Binding Positive Regulation Of Humoral Immune Response Leukocyte Migration Involved In Inflammatory Response Leukocyte Migration Amyloid-beta Clearance Cargo Receptor Activity Positive Regulation Of Immune Effector Process Cell Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Heterotypic Cell-cell Adhesion Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Motility Regulation Of Humoral Immune Response Macrophage Activation Endothelial Cell Migration C5L2 Anaphylatoxin Chemotactic Receptor Binding Low-affinity IgE Receptor Activity Granulocyte Migration Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Leukocyte Activation Cell-matrix Adhesion Positive Regulation Of Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response B Cell Antigen Processing And Presentation Myeloid Leukocyte Activation Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Myeloid Leukocyte Migration Integrin AlphaL-beta2 Complex Leukocyte Chemotaxis Immune System Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Vertebrate Eye-specific Patterning Fc Receptor-mediated Immune Complex Endocytosis ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-substrate Adhesion Negative Regulation Of Integrin Activation Regulation Of Cell Adhesion Receptor-mediated Endocytosis	Endoplasmic Reticulum Exit Site ER To Golgi Transport Vesicle Membrane COPII Vesicle Coat COPII-coated Vesicle Cargo Loading Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Vesicle Cargo Loading
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