ITGAX

Name	integrin subunit alpha X
Structure
Interactors	5 interactors: C3 FCER2 ITGB2 JAM3 MIA3
GO Annotations	Cellular Component	Plasma Membrane Integrin Complex External Side Of Plasma Membrane Cell Surface Membrane Secretory Granule Membrane Integrin AlphaX-beta2 Complex Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Integrin Binding Protein Binding Receptor Tyrosine Kinase Binding Signaling Receptor Activity Metal Ion Binding
	Biological Process	Cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Animal Organ Morphogenesis Positive Regulation Of Metabolic Process Positive Regulation Of Gene Expression Positive Regulation Of Cell Migration Positive Regulation Of Myelination Heterotypic Cell-cell Adhesion Positive Regulation Of Angiogenesis Defense Response To Virus Cell-cell Adhesion Positive Regulation Of Endothelial Tube Morphogenesis
Pathways	Cell surface interactions at the vascular wall Integrin cell surface interactions ECM proteoglycans Interleukin-4 and Interleukin-13 signaling Neutrophil degranulation
Drugs	Efalizumab
GWAS	IgA nephropathy ( 25305756 ) Post bronchodilator FEV1 ( 26634245 ) Systemic lupus erythematosus ( 18204098 )
Entrez ID	3687
HPRD ID	01051
Ensembl ID	ENSG00000140678
Uniprot IDs	H3BN02 P20702
PDB IDs	1N3Y 2LUV 3K6S 3K71 3K72 4NEH 4NEN 5ES4
GO Terms Enriched among Interactors ?	Positive Regulation Of Immune System Process Regulation Of Immune System Process Integrin Binding Positive Regulation Of Humoral Immune Response Leukocyte Migration Involved In Inflammatory Response Leukocyte Migration Amyloid-beta Clearance Cargo Receptor Activity Positive Regulation Of Immune Effector Process Cell Migration Cellular Response To Low-density Lipoprotein Particle Stimulus Heterotypic Cell-cell Adhesion Cellular Response To Lipoprotein Particle Stimulus Positive Regulation Of Immunoglobulin Mediated Immune Response Cell Motility Regulation Of Humoral Immune Response Macrophage Activation Endothelial Cell Migration C5L2 Anaphylatoxin Chemotactic Receptor Binding Low-affinity IgE Receptor Activity Granulocyte Migration Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Leukocyte Activation Cell-matrix Adhesion Positive Regulation Of Immune Response Positive Regulation Of Activation Of Membrane Attack Complex Positive Regulation Of Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Cell Activation Positive Regulation Of Lymphocyte Mediated Immunity Positive Regulation Of Adaptive Immune Response B Cell Antigen Processing And Presentation Myeloid Leukocyte Activation Integrin AlphaM-beta2 Complex Integrin AlphaX-beta2 Complex Myeloid Leukocyte Migration Integrin AlphaL-beta2 Complex Leukocyte Chemotaxis Immune System Process Regulation Of Mononuclear Cell Migration Positive Regulation Of Leukocyte Migration Complement-dependent Cytotoxicity Classical-complement-pathway C3/C5 Convertase Complex Vertebrate Eye-specific Patterning Fc Receptor-mediated Immune Complex Endocytosis ICAM-3 Receptor Activity Positive Regulation Of Neutrophil Degranulation Cell-substrate Adhesion Negative Regulation Of Integrin Activation Regulation Of Cell Adhesion Receptor-mediated Endocytosis