ITGAX and JAM3

Number of citations of the paper that reports this interaction (PMID 12208882)
65

Data Source:
HPRD (in vivo)

		ITGAX	JAM3
Gene Name		integrin, alpha X (complement component 3 receptor 4 subunit)	junctional adhesion molecule 3
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Plasma Membrane Integrin Complex Cell Surface Membrane	Extracellular Space Golgi Apparatus Plasma Membrane Tight Junction Integral Component Of Membrane Desmosome Paranodal Junction Schmidt-Lanterman Incisure Cell-cell Contact Zone
	Molecular Function	Receptor Activity Protein Binding Metal Ion Binding	Integrin Binding Protein Binding Protein Homodimerization Activity Protein Heterodimerization Activity
	Biological Process	Cell Adhesion Integrin-mediated Signaling Pathway Blood Coagulation Organ Morphogenesis Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Leukocyte Migration	Angiogenesis Neutrophil Homeostasis Adaptive Immune Response Myeloid Progenitor Cell Differentiation Leukocyte Migration Involved In Inflammatory Response Cell-matrix Adhesion Spermatid Development Blood Coagulation Transmission Of Nerve Impulse Establishment Of Cell Polarity Extracellular Matrix Organization Axon Regeneration Myelination Leukocyte Migration Regulation Of Neutrophil Chemotaxis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion
Pathways		ECM proteoglycans Integrin cell surface interactions Cell surface interactions at the vascular wall	Integrin cell surface interactions Cell surface interactions at the vascular wall
Drugs
Diseases
GWAS		Systemic lupus erythematosus ( 18204098)
Protein-Protein Interactions		4 interactors: C3 FCER2 ITGB2 JAM3	6 interactors: F2RL2 ITGAM ITGAX JAM2 PICK1 TJP1
Entrez ID		3687	83700
HPRD ID		01051	06042
Ensembl ID		ENSG00000140678	ENSG00000166086
Uniprot IDs		H3BN02 P20702 Q8TES5	Q9BX67
PDB IDs		1N3Y 2LUV 3K6S 3K71 3K72
Enriched GO Terms of Interacting Partners?		Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Humoral Immune Response Regulation Of Immune System Process Positive Regulation Of Immunoglobulin Mediated Immune Response Inflammatory Response Regulation Of Humoral Immune Response Positive Regulation Of Immune Response Positive Regulation Of Angiogenesis Regulation Of Actin Cytoskeleton Organization By Cell-cell Adhesion Regulation Of Immune Response Positive Regulation Of Immune System Process Positive Regulation Of Adaptive Immune Response Cell-matrix Adhesion Positive Regulation Of Type IIa Hypersensitivity Regulation Of Adaptive Immune Response Cell-substrate Adhesion Regulation Of Angiogenesis Leukocyte Migration Positive Regulation Of Activation Of Membrane Attack Complex Immune Response Defense Response Adaptive Immune Response Positive Regulation Of Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Hypersensitivity Positive Regulation Of Apoptotic Cell Clearance Positive Regulation Of Acute Inflammatory Response To Antigenic Stimulus Extracellular Matrix Organization Extracellular Structure Organization Myeloid Progenitor Cell Differentiation Positive Regulation Of Killing Of Cells Of Other Organism Regulation Of Killing Of Cells Of Other Organism Regulation Of Apoptotic Cell Clearance Blood Coagulation Hemostasis Complement Activation, Alternative Pathway Positive Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cellular Component Organization Positive Regulation Of Nitric-oxide Synthase Biosynthetic Process Neutrophil Homeostasis Single Organismal Cell-cell Adhesion Immune System Process Positive Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Positive Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Protein Processing Regulation Of Triglyceride Biosynthetic Process Signaling Regulation Of Body Fluid Levels Cell Communication Wound Healing Heterotypic Cell-cell Adhesion	Blood Coagulation Hemostasis Regulation Of Body Fluid Levels Wound Healing Response To Wounding Leukocyte Migration Extracellular Matrix Organization Extracellular Structure Organization Single Organismal Cell-cell Adhesion Cell-cell Signaling Involved In Cell-cell Junction Organization Glial Cell Development Response To Stress Integrin-mediated Signaling Pathway Response To External Stimulus Microglia Development Cell Migration Glial Cell Differentiation Response To Magnetism Cell Motility Ectodermal Cell Differentiation Gliogenesis Establishment Of Endothelial Intestinal Barrier Response To Stimulus DNA Methylation Involved In Embryo Development Cell Adhesion Dendritic Spine Maintenance Signal Transduction Locomotion Neuronal Ion Channel Clustering Thrombin Receptor Signaling Pathway Negative Regulation Of Arp2/3 Complex-mediated Actin Nucleation Negative Regulation Of Vascular Permeability Negative Regulation Of Actin Nucleation Cell Surface Receptor Signaling Pathway Signaling Cell Communication Movement Of Cell Or Subcellular Component Long Term Synaptic Depression Leukocyte Migration Involved In Inflammatory Response Positive Regulation Of Receptor Internalization Macrophage Differentiation Regulation Of Arp2/3 Complex-mediated Actin Nucleation Dendritic Spine Organization Heterotypic Cell-cell Adhesion DNA Methylation Involved In Gamete Generation Regulation Of Actin Nucleation Ectoderm Development Cellular Response To Glucose Starvation Monoamine Transport Cellular Component Maintenance
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