NISCH

Description		nischarin
Image
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Intercellular Bridge Recycling Endosome
	Molecular Function	Integrin Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding
	Biological Process	Apoptotic Process Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration
Pathways		RAC1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle
Drugs		Tizanidine Agmatine Moxonidine Tepotinib
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Parkinson's disease ( 28892059) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		1 novel interacting genes: TWF2
Interacting Genes		10 interacting genes: AR BTG3 CLIC6 IRS4 ITGA5 KLHL20 OGT PTGER4 VHL WEE2-AS1
Entrez ID		11188
HPRD ID		11391
Ensembl ID		ENSG00000010322
Uniprot IDs		C9J715 Q9Y2I1
PDB IDs		3P0C 8ESF
Enriched GO Terms of Interacting Partners?		Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Regulation Of Programmed Cell Death Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Integrin Alpha5-beta1 Complex Alphav-beta3 Integrin-vitronectin Complex Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Prostaglandin Receptor Activity Ubiquitin-like Ligase-substrate Adaptor Activity Regulation Of TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein O-acetylglucosaminyltransferase Activity Protein K33-linked Ubiquitination Type II Interferon Binding D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Pre-mRNA 5'-splice Site Binding
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