NISCH and IRS4

Number of citations of the paper that reports this interaction (PubMedID 11912194)
0

Data Source:
HPRD (in vivo)

		NISCH	IRS4
Description		nischarin	insulin receptor substrate 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Plasma Membrane Microtubule Cytoskeleton Membrane Intercellular Bridge Recycling Endosome	Cytosol Plasma Membrane Membrane
	Molecular Function	Integrin Binding Protein Binding Phosphatidylinositol Binding Identical Protein Binding	Insulin Receptor Binding Protein Binding Phosphatidylinositol 3-kinase Binding
	Biological Process	Apoptotic Process Rac Protein Signal Transduction Actin Cytoskeleton Organization Negative Regulation Of Cell Migration	Signal Transduction Insulin Receptor Signaling Pathway
Pathways		RAC1 GTPase cycle RND3 GTPase cycle RND2 GTPase cycle	IRS-related events triggered by IGF1R
Drugs		Tizanidine Agmatine Moxonidine Tepotinib
Diseases
GWAS		A body shape index ( 34021172) Apolipoprotein B levels ( 32203549) Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972 31043756) Colon cancer ( 33632709) Distal colorectal cancer ( 33632709) General cognitive ability ( 29844566) HDL cholesterol levels ( 32203549) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Parkinson's disease ( 28892059) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Schizophrenia ( 29483656 25056061 23974872) Triglyceride levels ( 32203549) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-hip ratio ( 20935629) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		10 interacting genes: AR BTG3 CLIC6 IRS4 ITGA5 KLHL20 OGT PTGER4 VHL WEE2-AS1	24 interacting genes: CRK CRKL CSNK1G2 EGFR ERBB2 GRB2 IGF1R MAGEL2 MAP1LC3A MTNR1A MTNR1B NDN NISCH OGT PIK3CA PIK3R1 PRKCZ PTEN PTPN11 PTPN6 RNF41 SOCS6 SOCS7 YWHAG
Entrez ID		11188	8471
HPRD ID		11391	04620
Ensembl ID		ENSG00000010322	ENSG00000133124
Uniprot IDs		C9J715 Q9Y2I1	A0A804CF45 O14654
PDB IDs		3P0C 8ESF
Enriched GO Terms of Interacting Partners?		Lateral Sprouting Involved In Mammary Gland Duct Morphogenesis Prostate Induction Regulation Of Programmed Cell Death Male Genitalia Morphogenesis POU Domain Binding Tertiary Branching Involved In Mammary Gland Duct Morphogenesis Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Programmed Cell Death Positive Regulation Of Developmental Process Negative Regulation Of Apoptotic Process Cellular Response To Oxygen-containing Compound Male Somatic Sex Determination Positive Regulation Of Integrin Biosynthetic Process Integrin Alpha5-beta1 Complex Alphav-beta3 Integrin-vitronectin Complex Negative Regulation Of Eosinophil Extravasation Negative Regulation Of Integrin Activation Negative Regulation Of Eosinophil Migration Regulation Of Protein-containing Complex Assembly Negative Regulation Of Protein-containing Complex Assembly Prostaglandin Receptor Activity Ubiquitin-like Ligase-substrate Adaptor Activity Regulation Of TORC1 Signaling Protein N-acetylglucosaminyltransferase Complex Negative Regulation Of Non-canonical Inflammasome Complex Assembly Protein O-acetylglucosaminyltransferase Activity Protein K33-linked Ubiquitination Type II Interferon Binding D2 Dopamine Receptor Binding D4 Dopamine Receptor Binding D3 Dopamine Receptor Binding Pre-mRNA 5'-splice Site Binding	Signal Transduction Intracellular Signal Transduction Insulin Receptor Substrate Binding Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Phosphotyrosine Residue Binding Regulation Of Signal Transduction Receptor Tyrosine Kinase Binding Enzyme-linked Receptor Protein Signaling Pathway Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Regulation Of Cell Communication Regulation Of Signaling Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signal Transduction Regulation Of Cell Adhesion Cell Surface Receptor Signaling Pathway Intracellular Signaling Cassette Regulation Of MAPK Cascade Positive Regulation Of Signaling Cytosol Epidermal Growth Factor Receptor Signaling Pathway Protein Modification Process ERBB Signaling Pathway Insulin Receptor Signaling Pathway Regulation Of Protein Localization To Membrane Positive Regulation Of Protein Localization To Membrane Insulin-like Growth Factor Receptor Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Cell Adhesion Regulation Of Protein Localization Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of Cell Adhesion Carbohydrate Homeostasis Glucose Homeostasis Phosphorylation-dependent Protein Binding Regulation Of Cell Migration Regulation Of Lymphocyte Activation Regulation Of Cellular Localization Regulation Of Immune System Process Negative Regulation Of Immune System Process Postsynaptic Specialization Assembly Regulation Of Cell Motility Reelin-mediated Signaling Pathway Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Leukocyte Cell-cell Adhesion Regulation Of Locomotion Regulation Of T Cell Activation Regulation Of Multicellular Organismal Process
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