ADAM28 and ITGA4

Number of citations of the paper that reports this interaction (PMID 11724793)
15

Data Source:
HPRD (in vitro)

		ADAM28	ITGA4
Gene Name		ADAM metallopeptidase domain 28	integrin, alpha 4 (antigen CD49D, alpha 4 subunit of VLA-4 receptor)
Image		No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Region Plasma Membrane Integral Component Of Membrane	Plasma Membrane Cell-cell Junction Focal Adhesion External Side Of Plasma Membrane Cell Surface Membrane Integrin Alpha4-beta7 Complex Extracellular Vesicular Exosome
	Molecular Function	Metalloendopeptidase Activity Metallopeptidase Activity Zinc Ion Binding	Fibronectin Binding Protein Binding Metal Ion Binding Cell Adhesion Molecule Binding
	Biological Process	Proteolysis Spermatogenesis	Blood Vessel Remodeling Cell-matrix Adhesion Involved In Ameboidal Cell Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Leukocyte Cell-cell Adhesion Cell-matrix Adhesion Integrin-mediated Signaling Pathway Heart Development Blood Coagulation B Cell Differentiation Extracellular Matrix Organization Heterotypic Cell-cell Adhesion Substrate Adhesion-dependent Cell Spreading Endodermal Cell Differentiation Receptor Clustering Regulation Of Immune Response Leukocyte Migration Leukocyte Tethering Or Rolling Face Development Chorio-allantoic Fusion T Cell Migration Negative Regulation Of Protein Homodimerization Activity
Pathways			Integrin cell surface interactions Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Cell surface interactions at the vascular wall Adaptive Immune System
Drugs			Natalizumab Tinzaparin
Diseases
GWAS		Height ( 20881960)	Celiac disease ( 20190752) Monocyte count ( 23314186) White blood cell count ( 21738480) White blood cell types ( 21738478)
Protein-Protein Interactions		1 interactors: ITGA4	16 interactors: ADAM28 CD81 CD82 EED FN1 ICAM4 ITGB1 ITGB7 LGALS8 LPXN MADCAM1 PRKACA PRKAR1A PXN TGFB1I1 VCAN
Entrez ID		10863	3676
HPRD ID		08391	01894
Ensembl ID		ENSG00000042980	ENSG00000115232
Uniprot IDs		Q9UKQ2	P13612
PDB IDs			3V4P 3V4V 4HKC
Enriched GO Terms of Interacting Partners?		Cell-matrix Adhesion Involved In Ameboidal Cell Migration Negative Regulation Of Protein Homodimerization Activity Chorio-allantoic Fusion Leukocyte Tethering Or Rolling T Cell Migration Regulation Of Protein Homodimerization Activity Heterotypic Cell-cell Adhesion Labyrinthine Layer Morphogenesis Embryonic Placenta Morphogenesis Cellular Extravasation Lymphocyte Migration Heterophilic Cell-cell Adhesion Via Plasma Membrane Cell Adhesion Molecules Endodermal Cell Differentiation Blood Vessel Remodeling Substrate Adhesion-dependent Cell Spreading Face Development Receptor Clustering Endoderm Formation Negative Regulation Of Protein Binding Labyrinthine Layer Development Endoderm Development Negative Regulation Of Binding B Cell Differentiation Tissue Remodeling Embryonic Placenta Development Integrin-mediated Signaling Pathway Formation Of Primary Germ Layer Regulation Of Protein Binding B Cell Activation Cell-matrix Adhesion Ameboidal-type Cell Migration Gastrulation Placenta Development Cell-substrate Adhesion Leukocyte Migration Lymphocyte Differentiation Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules Cell-cell Adhesion Regulation Of Binding Leukocyte Cell-cell Adhesion Leukocyte Differentiation Protein Localization To Membrane Extracellular Matrix Organization Extracellular Structure Organization Lymphocyte Activation Blood Coagulation Hemostasis Embryonic Organ Development Leukocyte Activation Reproductive Structure Development	Cell Adhesion Extracellular Matrix Organization Extracellular Structure Organization Cell-matrix Adhesion Leukocyte Tethering Or Rolling Cell-substrate Adhesion Leukocyte Migration Heterotypic Cell-cell Adhesion Regulation Of Immune System Process Integrin-mediated Signaling Pathway Cellular Extravasation Formation Of Primary Germ Layer Calcium-independent Cell-matrix Adhesion Positive Regulation Of Cellular Protein Metabolic Process Viral Entry Into Host Cell Substrate Adhesion-dependent Cell Spreading Entry Into Host Cell Positive Regulation Of Protein Metabolic Process Gastrulation Locomotion Cell Junction Assembly Cell Differentiation Cell Migration Cell Motility Positive Regulation Of Protein Modification Process Movement Of Cell Or Subcellular Component Mesoderm Formation Activation Of Protein Kinase Activity Mesoderm Morphogenesis Embryonic Morphogenesis Tissue Morphogenesis Interaction With Host Tissue Development Activation Of Protein Kinase A Activity Positive Regulation Of Protein Phosphorylation Positive Regulation Of Cellular Metabolic Process Regulation Of Cellular Component Organization Mesoderm Development Regulation Of Cellular Protein Metabolic Process Multicellular Organismal Development Blood Coagulation Hemostasis Positive Regulation Of Phosphorylation Positive Regulation Of MAPK Cascade Cardiovascular System Development Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Immune Response Anatomical Structure Development ERBB Signaling Pathway Renal Water Homeostasis
Tagcloud ?		1e 3e 7e accessed adenocarcinomas anxa3 cabig cadm1 ccne1 cd24 cdk1 cdkn2a com datasets demonstration ercc1 geo kmplot logrank online opn plot plotted rad51 repositories silico tcga uni www
Tagcloud (Difference) ?		1e 3e 7e accessed adenocarcinomas anxa3 cabig cadm1 ccne1 cd24 cdk1 cdkn2a com datasets demonstration ercc1 geo kmplot logrank online opn plot plotted rad51 repositories silico tcga uni www
Tagcloud (Intersection) ?