ADAM28

Description		ADAM metallopeptidase domain 28
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Mitochondrion Plasma Membrane Cell Surface Membrane
	Molecular Function	Metalloendopeptidase Activity Protein Binding Peptidase Activity Metallopeptidase Activity Hydrolase Activity Immunoglobulin Receptor Binding Metal Ion Binding
	Biological Process	Proteolysis Spermatogenesis
Pathways
Drugs		N-[(Furan-2-Yl)Carbonyl]-(S)-Leucyl-(R)-[1-Amino-2(1h-Indol-3-Yl)Ethyl]-Phosphonic Acid Furoyl-Leucine Ilomastat 2-(Thiomethylene)-4-Methylpentanoic Acid Pidolic acid Batimastat (2R,3R)-N^1^-[(1S)-2,2-DIMETHYL-1-(METHYLCARBAMOYL)PROPYL]-N^4^-HYDROXY-2-(2-METHYLPROPYL)-3-{[(1,3-THIAZOL-2-YLCARBONYL)AMINO]METHYL}BUTANEDIAMIDE
Diseases
GWAS		Ankylosing spondylitis ( 30946743) Blood urea nitrogen levels ( 29403010) Creatinine levels ( 29403010) Estimated glomerular filtration rate ( 31015462) Glomerular filtration rate ( 29403010) Hair greying ( 26926045) Height ( 20881960) Serum uric acid levels ( 30993211) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		2 interacting genes: ITGA4 PLAU
Entrez ID		10863
HPRD ID		08391
Ensembl ID		ENSG00000042980
Uniprot IDs		A0A384NKT9 Q9UKQ2
PDB IDs
Enriched GO Terms of Interacting Partners?		Clathrin-dependent Extracellular Exosome Endocytosis Cell-matrix Adhesion Involved In Ameboidal Cell Migration Negative Regulation Of Protein Homodimerization Activity Integrin Alpha4-beta7 Complex Urokinase Plasminogen Activator Signaling Pathway Integrin Alpha4-beta1 Complex C-X3-C Chemokine Binding Focal Adhesion Immune Response In Gut-associated Lymphoid Tissue Serine Protease Inhibitor Complex Regulation Of Smooth Muscle Cell-matrix Adhesion Positive Regulation Of Leukocyte Tethering Or Rolling Positive Regulation Of Locomotion Positive Regulation Of Cell Migration Diapedesis Axonogenesis Involved In Innervation Positive Regulation Of Cell Motility Protein Antigen Binding Cell-cell Adhesion Mediated By Integrin Serine-type Endopeptidase Complex Negative Regulation Of Plasminogen Activation Protein Complex Involved In Cell-matrix Adhesion Plasminogen Activation Negative Regulation Of Vasoconstriction Cell Surface Smooth Muscle Cell Migration Negative Regulation Of Fibrinolysis Regulation Of Leukocyte Tethering Or Rolling Regulation Of Fibrinolysis Regulation Of Plasminogen Activation Negative Regulation Of Protein Binding Regulation Of Cell Motility Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of T Cell Migration Fibronectin Binding Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cell Migration Regulation Of Cell Adhesion Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Locomotion Leukocyte Tethering Or Rolling Regulation Of Cellular Extravasation Endodermal Cell Differentiation Cell Migration Clathrin-dependent Endocytosis Integrin Complex Cell Motility Antigen Binding Regulation Of Vascular Endothelial Cell Proliferation Heterotypic Cell-cell Adhesion
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