AQP6 and CD81

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP6	CD81
Description		aquaporin 6	CD81 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Immunological Synapse Cytosol Plasma Membrane Focal Adhesion Basal Plasma Membrane Membrane Basolateral Plasma Membrane Vesicle Extracellular Exosome Tetraspanin-enriched Microdomain
	Molecular Function	Monoatomic Anion Channel Activity Protein Binding Ammonium Channel Activity Nitrate Transmembrane Transporter Activity Water Channel Activity Channel Activity Carbon Dioxide Transmembrane Transporter Activity PH-gated Chloride Channel Activity	Virus Receptor Activity Integrin Binding Protein Binding Lipid Binding Cholesterol Binding MHC Class II Protein Complex Binding MHC Class II Protein Binding Transferrin Receptor Binding
	Biological Process	Renal Water Transport Carbon Dioxide Transport Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transport Odontogenesis Transmembrane Transport Ammonium Transmembrane Transport Monoatomic Anion Transmembrane Transport Chloride Transmembrane Transport	Immunological Synapse Formation Adaptive Immune Response Immune System Process Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Inflammatory Response To Antigenic Stimulus Myoblast Fusion Involved In Skeletal Muscle Regeneration Positive Regulation Of B Cell Proliferation Receptor Internalization Regulation Of Protein Stability Macrophage Fusion CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Cell Population Proliferation Positive Regulation Of MAPK Cascade Positive Regulation Of Transcription By RNA Polymerase II Symbiont Entry Into Host Cell Positive Regulation Of B Cell Receptor Signaling Pathway Positive Regulation Of T Cell Receptor Signaling Pathway Positive Regulation Of B Cell Activation Protein Localization To Lysosome Positive Regulation Of Protein Exit From Endoplasmic Reticulum Cellular Response To Low-density Lipoprotein Particle Stimulus Protein Localization To Plasma Membrane Osteoclast Fusion Positive Regulation Of Receptor Clustering Positive Regulation Of Protein Catabolic Process In The Vacuole Regulation Of Macrophage Migration Positive Regulation Of Adaptive Immune Memory Response Regulation Of Cell Motility Positive Regulation Of T-helper 2 Cell Cytokine Production Positive Regulation Of CD4-positive, Alpha-beta T Cell Proliferation Positive Regulation Of T Cell Activation Via T Cell Receptor Contact With Antigen Bound To MHC Molecule On Antigen Presenting Cell
Pathways		Passive transport by Aquaporins	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell Regulation of Complement cascade
Drugs
Diseases
GWAS			Malaria ( 31844061)
Interacting Genes		327 interacting genes: ABCG1 ABHD16A ACSL5 ADGRE2 ADIPOQ AGMO AGPAT3 AGPAT4 AGTRAP AIG1 ALOX5AP ANKRD46 AOC2 APOA2 APOL3 AQP1 ARL6IP1 ARL6IP6 ARLN ARV1 ATP13A1 ATP6V0C BET1 BMP10 BRICD5 BSG BTN2A2 C14orf180 C1GALT1 C2CD2L C3orf52 C5 C5orf46 CATSPERH CCDC167 CCL22 CCL4L2 CD52 CD68 CD81 CDIPT CGREF1 CLDN19 CLDN4 CLDND2 CMTM3 CMTM5 CMTM7 CNIH1 CNIH3 CORIN COX20 CTSA CTXN3 CXCL16 CXCL9 CXorf66 CYB561 CYB561A3 CYB561D1 CYB5B CYB5R3 CYBC1 CYP4F2 CYP4F22 DEFB103A DEFB103B DEFB108B DEFB127 DERL1 DGAT2L6 DHRSX DNAJC30 EBP EFNA5 EMC6 EMD EMP1 EMP3 ERG28 ERMP1 FA2H FAM177A1 FAXDC2 FDFT1 FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GKN1 GOLT1A GOSR2 GPR151 GPR152 GPR25 GRM2 GYPC HMOX1 HMOX2 HSD3B1 HTATIP2 ICMT IFITM3 IFNGR1 IGFBP5 INSIG1 INSIG2 ITGAM JAGN1 JPH1 KCNK1 LEMD1 LEPROT LHFPL5 LNPEP LPAR3 LSS LY6D MAL MAL2 MALL MARCHF2 MARCHF5 MFF MGAM MGLL MIP MMP14 MS4A1 MS4A13 MYADML2 NAT8 NEU1 NINJ1 NINJ2 NKG7 NRM ORMDL1 ORMDL2 ORMDL3 OTULINL PAEP PDZK1IP1 PEDS1-UBE2V1 PEMT PEX11G PEX16 PIGF PLLP PLN PLP1 PLP2 PLPP6 PMP22 PRAF2 PRB1 PRH1 PRRT2 PTPN1 PTPN9 RAB18 RABAC1 REEP6 RFT1 RHD RPRM RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SCGB1A1 SEC22A SEC22B SEC61G SELENOK SERF1A SERF1B SERP1 SERP2 SFRP4 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SFXN5 SLC16A12 SLC16A13 SLC25A46 SLC30A2 SLC30A3 SLC30A8 SLC33A2 SLC35A1 SLC35B1 SLC35B2 SLC35B4 SLC35E4 SLC35F1 SLC35F6 SLC35G2 SLC38A1 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SLC7A8 SLCO3A1 SMAGP SMCO4 SMIM1 SNORC ST6GAL2 STARD3 STATH STRIT1 STX12 STX1B STX3 STX5 STX6 STX7 STX8 SYNDIG1 SYNGR1 SYNJ2BP TAP1 TBC1D20 TECR TFRC THBD THSD7A THSD7B TIMM23 TLCD1 TMEM100 TMEM107 TMEM11 TMEM115 TMEM119 TMEM120A TMEM120B TMEM128 TMEM140 TMEM143 TMEM144 TMEM14A TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM69 TMEM74 TMEM86B TMEM97 TMIE TMUB2 TMX2 TNFRSF10C TOMM22 TOMM6 TPRG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBE2J2 UBIAD1 UBTD2 UBXN8 UNC50 UNC93A UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB VEZT VKORC1L1 VMA12 VMA21 VRK2 VSTM1 VTI1B WFS1 XKR3 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC21 ZDHHC24 ZFPL1 ZNF587	62 interacting genes: ADRA1A ADRB2 AQP6 BDKRB2 BST2 CCR2 CCR9 CD19 CD79A CD9 CHRM4 CPLX4 CSNK2B DLG5 EBP ERGIC3 F2RL1 FAM209A FKBP7 GJA4 GLP1R GORAB GPR152 GPR35 GPX8 HNRNPD HRH1 HTR4 IFITM1 IGSF8 INO80B ITGA4 JAK3 KIT LBR LHFPL5 LMNA MC4R MCEE MRPS18B MYCBP2 MYOC NEMP1 OXTR PDZK1IP1 PTGFRN RBBP6 RNF128 SAR1A SDHAF4 SHC1 SIRPA SLC18A1 SLC26A6 STX1A THAP4 TMX2 TREX1 TSHR TSPAN4 VKORC1 ZBTB16
Entrez ID		363	975
HPRD ID		03226	08924
Ensembl ID		ENSG00000086159	ENSG00000110651
Uniprot IDs		Q13520	A6NMH8 E9PJK1 H0YEE2 P60033
PDB IDs			1G8Q 1IV5 3X0E 5DFV 5DFW 5M2C 5M33 5M3D 5M3T 5M4R 5TCX 6EJG 6EJM 6EK2 6U9S 7JIC
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Organization Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Cellular Localization Establishment Of Protein Localization Organelle Fusion Golgi Membrane Lipid Biosynthetic Process Transmembrane Transport Sterol Biosynthetic Process Membrane Docking Organelle Localization By Membrane Tethering SNARE Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle-mediated Transport Steroid Biosynthetic Process Intracellular Transport Plasma Membrane Vesicle Organization Vesicle Docking Synaptic Vesicle Membrane Cholesterol Biosynthetic Process Golgi Vesicle Transport Amino Acid Transport Structural Constituent Of Myelin Sheath Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Sterol Metabolic Process Chemical Homeostasis Monoatomic Ion Transmembrane Transporter Activity Establishment Of Localization In Cell Mitochondrial Outer Membrane Organic Anion Transport Zinc Ion Transmembrane Transporter Activity Mitochondrial Transport Amino Acid Transmembrane Transport Serine Import Into Mitochondrion Cytoplasmic Vesicle Zinc Ion Transmembrane Transport Transmembrane Transporter Activity Zinc Ion Transport Establishment Of Protein Localization To Membrane	G Protein-coupled Receptor Activity Membrane G Protein-coupled Receptor Signaling Pathway Plasma Membrane Positive Regulation Of Cytosolic Calcium Ion Concentration Blood Vessel Diameter Maintenance Regulation Of Tube Size System Process Regulation Of Multicellular Organismal Process Regulation Of Vasoconstriction Regulation Of System Process Negative Regulation Of Dendritic Cell Cytokine Production Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Biological Quality Circulatory System Process Regulation Of Locomotion Regulation Of Dendritic Cell Cytokine Production Myoblast Fusion Involved In Skeletal Muscle Regeneration G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Vascular Process In Circulatory System Cell Surface Receptor Signaling Pathway B Cell Differentiation B Cell Activation Leukocyte Differentiation Chemokine Receptor Activity Developmental Process Regulation Of Production Of Molecular Mediator Of Immune Response Secretion Regulation Of Cytokine Production Involved In Immune Response Cell Activation Cytokine-mediated Signaling Pathway Response To Psychosocial Stress Monocyte Extravasation Positive Regulation Of Vasoconstriction Regulation Of Cell Migration Mononuclear Cell Differentiation Leukocyte Activation Negative Regulation Of Viral Life Cycle Negative Regulation Of Multicellular Organismal Process Lymphocyte Activation Response To Interferon-beta Regulation Of Cell Motility Lymphocyte Differentiation Regulation Of Blood Circulation Regulation Of Blood Pressure Adrenergic Receptor Activity Protein Antigen Binding Ossification Involved In Bone Maturation Positive Regulation Of Cold-induced Thermogenesis
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