AQP6 and MGAM

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AQP6	MGAM
Description		aquaporin 6	maltase-glucoamylase
Image		No pdb structure
GO Annotations	Cellular Component	Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle	Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Monoatomic Anion Channel Activity Protein Binding Ammonium Channel Activity Nitrate Transmembrane Transporter Activity Water Channel Activity Channel Activity Carbon Dioxide Transmembrane Transporter Activity PH-gated Chloride Channel Activity	Catalytic Activity Glucan 1,4-alpha-glucosidase Activity Hydrolase Activity, Hydrolyzing O-glycosyl Compounds Alpha-1,4-glucosidase Activity Oligo-1,6-glucosidase Activity Protein Binding Amylase Activity Hydrolase Activity Hydrolase Activity, Acting On Glycosyl Bonds Carbohydrate Binding Alpha-glucosidase Activity
	Biological Process	Renal Water Transport Carbon Dioxide Transport Nitrate Transmembrane Transport Carbon Dioxide Transmembrane Transport Odontogenesis Transmembrane Transport Ammonium Transmembrane Transport Monoatomic Anion Transmembrane Transport Chloride Transmembrane Transport	Maltose Catabolic Process Carbohydrate Metabolic Process Starch Catabolic Process Disaccharide Catabolic Process Dextrin Catabolic Process
Pathways		Passive transport by Aquaporins	Digestion of dietary carbohydrate Neutrophil degranulation
Drugs			Acarbose Miglitol Voglibose
Diseases
GWAS			1,5-anhydroglucitol levels ( 28588231) Anorexia nervosa ( 23568457) Idiopathic dilated cardiomyopathy ( 29495422)
Interacting Genes		327 interacting genes: ABCG1 ABHD16A ACSL5 ADGRE2 ADIPOQ AGMO AGPAT3 AGPAT4 AGTRAP AIG1 ALOX5AP ANKRD46 AOC2 APOA2 APOL3 AQP1 ARL6IP1 ARL6IP6 ARLN ARV1 ATP13A1 ATP6V0C BET1 BMP10 BRICD5 BSG BTN2A2 C14orf180 C1GALT1 C2CD2L C3orf52 C5 C5orf46 CATSPERH CCDC167 CCL22 CCL4L2 CD52 CD68 CD81 CDIPT CGREF1 CLDN19 CLDN4 CLDND2 CMTM3 CMTM5 CMTM7 CNIH1 CNIH3 CORIN COX20 CTSA CTXN3 CXCL16 CXCL9 CXorf66 CYB561 CYB561A3 CYB561D1 CYB5B CYB5R3 CYBC1 CYP4F2 CYP4F22 DEFB103A DEFB103B DEFB108B DEFB127 DERL1 DGAT2L6 DHRSX DNAJC30 EBP EFNA5 EMC6 EMD EMP1 EMP3 ERG28 ERMP1 FA2H FAM177A1 FAXDC2 FDFT1 FIS1 FKBP8 FUNDC2 FXYD3 FXYD6 FXYD6-FXYD2 GAST GIMAP1 GIMAP5 GJB2 GKN1 GOLT1A GOSR2 GPR151 GPR152 GPR25 GRM2 GYPC HMOX1 HMOX2 HSD3B1 HTATIP2 ICMT IFITM3 IFNGR1 IGFBP5 INSIG1 INSIG2 ITGAM JAGN1 JPH1 KCNK1 LEMD1 LEPROT LHFPL5 LNPEP LPAR3 LSS LY6D MAL MAL2 MALL MARCHF2 MARCHF5 MFF MGAM MGLL MIP MMP14 MS4A1 MS4A13 MYADML2 NAT8 NEU1 NINJ1 NINJ2 NKG7 NRM ORMDL1 ORMDL2 ORMDL3 OTULINL PAEP PDZK1IP1 PEDS1-UBE2V1 PEMT PEX11G PEX16 PIGF PLLP PLN PLP1 PLP2 PLPP6 PMP22 PRAF2 PRB1 PRH1 PRRT2 PTPN1 PTPN9 RAB18 RABAC1 REEP6 RFT1 RHD RPRM RTP2 RUSF1 SACM1L SCAMP4 SCAMP5 SCD SCGB1A1 SEC22A SEC22B SEC61G SELENOK SERF1A SERF1B SERP1 SERP2 SFRP4 SFT2D1 SFT2D2 SFXN1 SFXN2 SFXN3 SFXN5 SLC16A12 SLC16A13 SLC25A46 SLC30A2 SLC30A3 SLC30A8 SLC33A2 SLC35A1 SLC35B1 SLC35B2 SLC35B4 SLC35E4 SLC35F1 SLC35F6 SLC35G2 SLC38A1 SLC38A7 SLC39A2 SLC39A7 SLC39A9 SLC41A1 SLC41A2 SLC52A1 SLC61A1 SLC66A1 SLC66A2 SLC7A1 SLC7A8 SLCO3A1 SMAGP SMCO4 SMIM1 SNORC ST6GAL2 STARD3 STATH STRIT1 STX12 STX1B STX3 STX5 STX6 STX7 STX8 SYNDIG1 SYNGR1 SYNJ2BP TAP1 TBC1D20 TECR TFRC THBD THSD7A THSD7B TIMM23 TLCD1 TMEM100 TMEM107 TMEM11 TMEM115 TMEM119 TMEM120A TMEM120B TMEM128 TMEM140 TMEM143 TMEM144 TMEM14A TMEM14C TMEM167B TMEM19 TMEM203 TMEM218 TMEM222 TMEM229B TMEM234 TMEM239 TMEM242 TMEM243 TMEM254 TMEM42 TMEM50A TMEM51 TMEM60 TMEM65 TMEM69 TMEM74 TMEM86B TMEM97 TMIE TMUB2 TMX2 TNFRSF10C TOMM22 TOMM6 TPRG1 TREX1 TSNARE1 TSPO2 UBE2J1 UBE2J2 UBIAD1 UBTD2 UBXN8 UNC50 UNC93A UNC93B1 USE1 VAMP1 VAMP2 VAMP3 VAMP4 VAMP5 VAPA VAPB VEZT VKORC1L1 VMA12 VMA21 VRK2 VSTM1 VTI1B WFS1 XKR3 YIF1A YIPF1 YIPF2 YIPF4 YIPF6 ZDHHC21 ZDHHC24 ZFPL1 ZNF587	7 interacting genes: AQP6 CPLX4 CREB3L1 GPR42 NCF1 SLC18A1 TMEM14B
Entrez ID		363	8972
HPRD ID		03226	01104
Ensembl ID		ENSG00000086159	ENSG00000257335
Uniprot IDs		Q13520	O43451
PDB IDs			2QLY 2QMJ 3CTT 3L4T 3L4U 3L4V 3L4W 3L4X 3L4Y 3L4Z 3TON 3TOP
Enriched GO Terms of Interacting Partners?		Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Protein Binding SNAP Receptor Activity SNARE Complex Endomembrane System Membrane Organization Membrane Fusion Vesicle Fusion Organelle Membrane Fusion Cellular Localization Establishment Of Protein Localization Organelle Fusion Golgi Membrane Lipid Biosynthetic Process Transmembrane Transport Sterol Biosynthetic Process Membrane Docking Organelle Localization By Membrane Tethering SNARE Binding Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Vesicle-mediated Transport Steroid Biosynthetic Process Intracellular Transport Plasma Membrane Vesicle Organization Vesicle Docking Synaptic Vesicle Membrane Cholesterol Biosynthetic Process Golgi Vesicle Transport Amino Acid Transport Structural Constituent Of Myelin Sheath Protein Transport Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Sterol Metabolic Process Chemical Homeostasis Monoatomic Ion Transmembrane Transporter Activity Establishment Of Localization In Cell Mitochondrial Outer Membrane Organic Anion Transport Zinc Ion Transmembrane Transporter Activity Mitochondrial Transport Amino Acid Transmembrane Transport Serine Import Into Mitochondrion Cytoplasmic Vesicle Zinc Ion Transmembrane Transport Transmembrane Transporter Activity Zinc Ion Transport Establishment Of Protein Localization To Membrane	PH-gated Chloride Channel Activity Nitrate Transmembrane Transporter Activity Nitrate Transmembrane Transport Membrane Vesicle-mediated Transport In Synapse Erythrocyte Apoptotic Process Neurotransmitter Transport Terminal Bouton Aminergic Neurotransmitter Loading Into Synaptic Vesicle Neutrophil-mediated Killing Of Fungus Monoatomic Anion Channel Activity Carbon Dioxide Transmembrane Transporter Activity Ammonium Transmembrane Transport Ammonium Channel Activity Renal Water Transport Carbon Dioxide Transmembrane Transport Thioesterase Binding Positive Regulation Of Keratinocyte Migration Presynapse Maintenance Of Postsynaptic Specialization Structure Positive Regulation Of Mitotic Cytokinetic Process Cellular Response To Diacyl Bacterial Lipopeptide Negative Regulation Of Dendrite Development Protein Localization To Cleavage Furrow Positive Regulation Of Focal Adhesion Disassembly Cellular Response To Bacterial Lipopeptide Maintenance Of Postsynaptic Density Structure Monoamine:proton Antiporter Activity Serotonin Uptake Amine Transport Clathrin-sculpted Monoamine Transport Vesicle Membrane Serotonin:sodium:chloride Symporter Activity Catecholamine Uptake Dopamine Uptake Norepinephrine Transport Monoamine Transmembrane Transporter Activity Norepinephrine Uptake Neurotransmitter Loading Into Synaptic Vesicle Extracellular Matrix Constituent Secretion Neutrophil-mediated Killing Of Gram-positive Bacterium Neutrophil-mediated Killing Of Bacterium Respiratory Burst Involved In Defense Response Phagolysosome Hydrogen Peroxide Biosynthetic Process Cellular Response To Testosterone Stimulus Superoxide-generating NAD(P)H Oxidase Activity Regulation Of Respiratory Burst Involved In Inflammatory Response Superoxide-generating NADPH Oxidase Activator Activity
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