IL16 and KCNJ2

Number of citations of the paper that reports this interaction (PMID 10479680)
9

Data Source:
BioGRID (two hybrid, affinity chromatography technology)
HPRD (two hybrid, in vivo)

		IL16	KCNJ2
Gene Name		interleukin 16	potassium channel, inwardly rectifying subfamily J, member 2
Image			No pdb structure
Gene Ontology Annotations	Cellular Component	Extracellular Space Nucleus Cytoplasm Plasma Membrane	Smooth Endoplasmic Reticulum Rough Endoplasmic Reticulum Golgi Apparatus Plasma Membrane Integral Component Of Plasma Membrane Voltage-gated Potassium Channel Complex Intercalated Disc T-tubule Intrinsic Component Of Membrane Neuronal Cell Body Dendritic Spine
	Molecular Function	Cytokine Activity	Inward Rectifier Potassium Channel Activity Phosphatidylinositol-4,5-bisphosphate Binding Identical Protein Binding Voltage-gated Potassium Channel Activity Involved In Cardiac Muscle Cell Action Potential Repolarization
	Biological Process	Transcription, DNA-templated Regulation Of Transcription, DNA-templated Immune Response Viral Process Leukocyte Chemotaxis Induction Of Positive Chemotaxis	Potassium Ion Transport Synaptic Transmission Potassium Ion Import Regulation Of Skeletal Muscle Contraction Via Regulation Of Action Potential Magnesium Ion Transport Cellular Potassium Ion Homeostasis Protein Homotetramerization Relaxation Of Cardiac Muscle Regulation Of Resting Membrane Potential Regulation Of Membrane Repolarization Cellular Response To Mechanical Stimulus Potassium Ion Transmembrane Transport Cardiac Muscle Cell Action Potential Involved In Contraction Membrane Repolarization During Action Potential Membrane Depolarization During Cardiac Muscle Cell Action Potential Membrane Repolarization During Cardiac Muscle Cell Action Potential Regulation Of Heart Rate By Cardiac Conduction Relaxation Of Skeletal Muscle Positive Regulation Of Potassium Ion Transmembrane Transport
Pathways			GABA B receptor activation Inwardly rectifying K+ channels GABA receptor activation Activation of G protein gated Potassium channels Classical Kir channels Activation of GABAB receptors Potassium Channels Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits Transmission across Chemical Synapses
Drugs
Diseases
GWAS		Inattentive symptoms ( 18821565)	Cardiac repolarization ( 22342860) Formal thought disorder in schizophrenia ( 22648509) Obesity-related traits ( 23251661) Primary tooth development (number of teeth) ( 23704328 20195514) Primary tooth development (time to first tooth eruption) ( 23704328 20195514) Pulmonary function (interaction) ( 23284291) QT interval ( 19305409) Refractive error ( 23396134) Thyrotoxic hypokalemic periodic paralysis ( 22863731 22399142)
Protein-Protein Interactions		28 interactors: CASP3 CD4 CDK1 CSNK2A1 CSNK2A2 DMRTB1 EFEMP2 GABPB1 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 KCNA3 KCND1 KCND2 KCNJ1 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KDM1A PPP1R12A PPP1R12B PPP1R12C SSSCA1 SUV39H1 USHBP1	14 interactors: AKAP5 CASK DLG1 DLG2 DLG3 DLG4 FLNA IL16 INADL KCNJ11 KCNJ16 KCNJ4 KCNJ8 TRAK2
Entrez ID		3603	3759
HPRD ID		04329	02815
Ensembl ID		ENSG00000172349	ENSG00000123700
Uniprot IDs		Q14005 Q9UME6	P63252
PDB IDs		1I16 1X6D
Enriched GO Terms of Interacting Partners?		Synaptic Transmission Potassium Ion Transmembrane Transport Potassium Ion Transport Potassium Ion Import Cell-cell Signaling Cation Transmembrane Transport Signaling Cell Communication Ion Transmembrane Transport Metal Ion Transport Regulation Of Ion Transmembrane Transport Cation Transport Transmembrane Transport Ion Transport Ionotropic Glutamate Receptor Signaling Pathway Synaptic Transmission, Glutamatergic Regulation Of Ion Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Cellular Process Glutamate Receptor Signaling Pathway Neuron-neuron Synaptic Transmission Regulation Of Sensory Perception Of Pain Startle Response Directional Locomotion Protein Homooligomerization Membrane Depolarization Negative Regulation Of Protein Catabolic Process Neuromuscular Process Regulation Of Resting Membrane Potential Regulation Of Neurological System Process Regulation Of Protein Catabolic Process Cell Cycle Regulation Of Excitatory Postsynaptic Membrane Potential Mitotic Cell Cycle Process Regulation Of Postsynaptic Membrane Potential Response To Wounding Protein Complex Assembly Cell Cycle Process Protein Oligomerization Negative Regulation Of Cell Cycle Potassium Ion Homeostasis Mitotic Cell Cycle Negative Regulation Of Chromosome Organization Locomotion G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Protein Metabolic Process Regulation Of Protein Metabolic Process Cellular Process Response To External Stimulus	Receptor Localization To Synapse Synaptic Transmission Receptor Clustering Nucleotide Phosphorylation Protein Localization To Synapse Cell-cell Signaling Potassium Ion Import Regulation Of Ion Transmembrane Transport Regulation Of Ion Transport Establishment Or Maintenance Of Apical/basal Cell Polarity Protein Localization To Membrane Potassium Ion Transmembrane Transport Cellular Protein Localization Potassium Ion Transport Nucleotide Metabolic Process Signaling Nucleobase-containing Small Molecule Metabolic Process Cell Communication Protein Localization Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Cellular Process Metal Ion Transport Membrane Organization Cortical Actin Cytoskeleton Organization Cortical Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Small Molecule Metabolic Process Cellular Localization Positive Regulation Of Ion Transport Cell Junction Assembly Organophosphate Metabolic Process Chemotaxis Tight Junction Assembly Cation Transport Monovalent Inorganic Cation Transport Regulation Of Membrane Potential Regulation Of Establishment Of Protein Localization Transport Negative Regulation Of Phosphatase Activity Cell Morphogenesis Involved In Differentiation Positive Regulation Of Transport Negative Regulation Of Dephosphorylation Apical Junction Assembly Regulation Of Protein Localization Positive Regulation Of Ion Transmembrane Transport Cell Projection Morphogenesis Cell Part Morphogenesis Protein Stabilization Axon Guidance Negative Regulation Of Transport
Tagcloud ?			alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Difference) ?			alpha1 alpha1beta1gamma1 alphak45r ampk ampkalpha1 ampkbeta1 ampkgamma1 andersen arrhythmia beta1gamma1 coexpression crna currents dead gammar70q inward ischaemia k45r kir2 myocytes nedd4 paralysis participates periodic r70q rectifier s795a tawil xenopus
Tagcloud (Intersection) ?