IL16 and KCNJ10

Number of citations of the paper that reports this interaction (PubMedID 10479680)
61

Data Source:
HPRD (two hybrid, in vitro)

		IL16	KCNJ10
Description		interleukin 16	potassium inwardly rectifying channel subfamily J member 10
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Nuclear Speck Flemming Body	Plasma Membrane Membrane Basolateral Plasma Membrane Monoatomic Ion Channel Complex Cell Body Astrocyte Projection Ciliary Base Presynapse
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding CD4 Receptor Binding	Nucleotide Binding Inward Rectifier Potassium Channel Activity Potassium Channel Activity Protein Binding ATP Binding ATP-activated Inward Rectifier Potassium Channel Activity
	Biological Process	Immune System Process Chemotaxis Immune Response Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport Positive Regulation Of Neutrophil Activation	Monoatomic Ion Transport Potassium Ion Transport Visual Perception Adult Walking Behavior Oligodendrocyte Development Central Nervous System Myelination Metal Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Cellular Response To Potassium Ion Regulation Of Membrane Potential Regulation Of Long-term Neuronal Synaptic Plasticity Establishment Of Localization In Cell Glutamate Reuptake Potassium Ion Homeostasis Regulation Of Resting Membrane Potential Potassium Ion Transmembrane Transport Non-motile Cilium Assembly Potassium Ion Import Across Plasma Membrane
Pathways		Other interleukin signaling	Activation of G protein gated Potassium channels Potassium transport channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ritodrine Yohimbine Butamben
Diseases			Seizures-sensorineural deafness-ataxia-mental retardation-electrolyte imbalance (SESAME) ; SeSAME/EAST syndrome
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Lymphocyte count ( 32888494) Primary biliary cholangitis ( 28425483)
Interacting Genes		108 interacting genes: ANXA6 BLZF1 BOLA2 BOLA2B CALCOCO2 CAMK1 CARD10 CASP3 CCDC184 CCDC33 CD4 CDK1 CEP72 CSNK2A1 CSNK2A2 CYSRT1 DMRTB1 DUSP7 EFEMP2 FAM124A FHL2 FHL5 FTO GABPB1 GOLGA2 GOLGA6L9 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 HOMEZ HOOK2 HSF2BP JAKMIP1 KANK2 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KCTD9 KDM1A KIF16B KIFC3 KRT31 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP3-1 L3MBTL3 LGALS14 LMO3 LNX1 LNX2 MBD3L1 MID2 MIER2 MTUS2 MYOG NOXA1 NTAQ1 OIP5 PDLIM7 PFDN5 PICK1 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PRDM6 PRR13 PSTPIP1 RAPGEF2 RBCK1 RNF144B SERTAD3 SMARCB1 SOHLH1 SPRED1 SUV39H1 TEPSIN TFIP11 TRIB3 TRIM23 TRIM27 TRIM42 TRIP6 UBXN11 USHBP1 WWTR1 ZBTB39 ZIM2 ZNF143 ZNF165 ZNF474 ZNF526 ZNF572 ZNF581 ZNF620 ZNF774 ZNF777 ZNF835 ZNRD2 ZRANB1	9 interacting genes: APP DLG1 DLG4 IL16 KCNJ16 PATJ SIAH1 SNCA SNTA1
Entrez ID		3603	3766
HPRD ID		04329	03732
Ensembl ID		ENSG00000172349	ENSG00000177807
Uniprot IDs		A0A8C8KBU6 Q14005 Q9UME6	P78508
PDB IDs		1I16 1X6D 5FB8
Enriched GO Terms of Interacting Partners?		Protein Binding Myosin Phosphatase Regulator Activity NMDA Glutamate Receptor Activity NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Zinc Ion Binding Identical Protein Binding Phosphatase Regulator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Inward Rectifier Potassium Channel Activity Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Channel Complex Glutamate-gated Calcium Ion Channel Activity Keratin Filament Regulation Of RNA Metabolic Process Regulation Of Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein Kinase CK2 Complex Directional Locomotion Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Membrane Potassium Ion Transport Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ligand-gated Ion Channel Signaling Pathway Potassium Channel Activity Voltage-gated Potassium Channel Complex Synaptic Transmission, Glutamatergic Potassium Ion Import Across Plasma Membrane PDZ Domain Binding Regulation Of Primary Metabolic Process Protein Complex Oligomerization Stress Fiber A-type (transient Outward) Potassium Channel Activity Metal Ion Binding Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Transcription Corepressor Activity Metal Ion Transport Muscle Cell Development Long-term Synaptic Potentiation Regulation Of Postsynaptic Membrane Potential	Regulation Of Monoatomic Ion Transport Regulation Of Long-term Neuronal Synaptic Plasticity Regulation Of Monoatomic Ion Transmembrane Transport Amyloid Fibril Formation Regulation Of Metal Ion Transport Regulation Of Membrane Potential Regulation Of Transport Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Regulation Of Neuronal Synaptic Plasticity NMDA Selective Glutamate Receptor Signaling Pathway Synaptic Membrane Regulation Of Monoatomic Cation Transmembrane Transport Neuromuscular Junction Chemical Synaptic Transmission Trans-synaptic Signaling Acetylcholine Receptor Binding Synaptic Signaling Neurotransmitter Receptor Localization To Postsynaptic Specialization Membrane Positive Regulation Of Synaptic Transmission Regulation Of Neurotransmitter Uptake Cell Junction Organization Cellular Response To Copper Ion Establishment Or Maintenance Of Cell Polarity Regulation Of Presynapse Organization Positive Regulation Of Inflammatory Response Regulation Of Presynapse Assembly Cellular Response To Metal Ion Supramolecular Fiber Organization Ionotropic Glutamate Receptor Signaling Pathway Microglial Cell Activation Ionotropic Glutamate Receptor Binding Locomotory Behavior Positive Regulation Of Excitatory Postsynaptic Potential Regulation Of System Process Leukocyte Activation Involved In Inflammatory Response Protein Localization To Postsynaptic Membrane Cell Junction Protein Localization To Postsynapse Regulation Of Synaptic Plasticity Response To Copper Ion Plasma Membrane Cell-cell Signaling Regulation Of Sodium Ion Transmembrane Transport Regulation Of Calcium Ion Transport Presynapse Postsynapse Ligand-gated Ion Channel Signaling Pathway Signaling Regulation Of Cell Activation
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