IL16 and KCTD9

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL16	KCTD9
Description		interleukin 16	potassium channel tetramerization domain containing 9
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Nuclear Speck Flemming Body
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding CD4 Receptor Binding	Protein Binding Identical Protein Binding Cullin Family Protein Binding
	Biological Process	Immune System Process Chemotaxis Immune Response Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport Positive Regulation Of Neutrophil Activation	Protein Ubiquitination Intracellular Signal Transduction Protein Homooligomerization
Pathways		Other interleukin signaling
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Lymphocyte count ( 32888494) Primary biliary cholangitis ( 28425483)	Lymphocyte count ( 32888494)
Interacting Genes		108 interacting genes: ANXA6 BLZF1 BOLA2 BOLA2B CALCOCO2 CAMK1 CARD10 CASP3 CCDC184 CCDC33 CD4 CDK1 CEP72 CSNK2A1 CSNK2A2 CYSRT1 DMRTB1 DUSP7 EFEMP2 FAM124A FHL2 FHL5 FTO GABPB1 GOLGA2 GOLGA6L9 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 HOMEZ HOOK2 HSF2BP JAKMIP1 KANK2 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KCTD9 KDM1A KIF16B KIFC3 KRT31 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP3-1 L3MBTL3 LGALS14 LMO3 LNX1 LNX2 MBD3L1 MID2 MIER2 MTUS2 MYOG NOXA1 NTAQ1 OIP5 PDLIM7 PFDN5 PICK1 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PRDM6 PRR13 PSTPIP1 RAPGEF2 RBCK1 RNF144B SERTAD3 SMARCB1 SOHLH1 SPRED1 SUV39H1 TEPSIN TFIP11 TRIB3 TRIM23 TRIM27 TRIM42 TRIP6 UBXN11 USHBP1 WWTR1 ZBTB39 ZIM2 ZNF143 ZNF165 ZNF474 ZNF526 ZNF572 ZNF581 ZNF620 ZNF774 ZNF777 ZNF835 ZNRD2 ZRANB1	91 interacting genes: ACTMAP ADAMTSL4 ANKS1A AQP1 ARID5A BANP BLZF1 CARD9 CBX8 CCDC33 CDC37 CDPF1 CFP CRADD DDIT4L DEUP1 EHHADH EPM2AIP1 FAM124B GEM GOLGA6L9 GORASP2 GPANK1 HOXA1 HOXC8 IGFN1 IL16 INCA1 KIF9 KLHL26 KRT31 KRT34 KRT35 KRT40 KRTAP13-2 KRTAP13-3 LNX1 LONRF1 MAD2L2 MBD3L1 MEOX2 MIIP MVP NDUFAB1 NIF3L1 NTAQ1 PDZD4 PFDN5 PICK1 PLOD3 PNKD POF1B PPP1R16B PPP1R18 PRDM6 PRKAA2 PSMA1 PSMB2 RBPMS RFX6 RUSC1 SAXO4 SDCBP SKP1 SLAIN1 SMARCB1 SMUG1 SPATS1 SPG21 SPMIP4 SPMIP6 SPMIP9 STX11 SYT6 TASOR2 TEPSIN TNS2 TRIM27 TRIM32 TRIM42 TRIP6 UNKL USP21 USP54 WDR83 ZBTB25 ZBTB42 ZNF408 ZNF426 ZNF620 ZNF76
Entrez ID		3603	54793
HPRD ID		04329	13772
Ensembl ID		ENSG00000172349	ENSG00000104756
Uniprot IDs		A0A8C8KBU6 Q14005 Q9UME6	Q7L273
PDB IDs		1I16 1X6D 5FB8	5BXH
Enriched GO Terms of Interacting Partners?		Protein Binding Myosin Phosphatase Regulator Activity NMDA Glutamate Receptor Activity NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Zinc Ion Binding Identical Protein Binding Phosphatase Regulator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Inward Rectifier Potassium Channel Activity Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Channel Complex Glutamate-gated Calcium Ion Channel Activity Keratin Filament Regulation Of RNA Metabolic Process Regulation Of Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein Kinase CK2 Complex Directional Locomotion Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Membrane Potassium Ion Transport Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ligand-gated Ion Channel Signaling Pathway Potassium Channel Activity Voltage-gated Potassium Channel Complex Synaptic Transmission, Glutamatergic Potassium Ion Import Across Plasma Membrane PDZ Domain Binding Regulation Of Primary Metabolic Process Protein Complex Oligomerization Stress Fiber A-type (transient Outward) Potassium Channel Activity Metal Ion Binding Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Transcription Corepressor Activity Metal Ion Transport Muscle Cell Development Long-term Synaptic Potentiation Regulation Of Postsynaptic Membrane Potential	Protein Binding Identical Protein Binding
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