IL16 and KIF16B

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		IL16	KIF16B
Description		interleukin 16	kinesin family member 16B
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Focal Adhesion Nuclear Speck Flemming Body	Cytoplasm Endosome Early Endosome Spindle Cytosol Cytoskeleton Kinesin Complex Microtubule Membrane Cytoplasmic Vesicle Early Endosome Membrane
	Molecular Function	Signaling Receptor Binding Cytokine Activity Protein Binding CD4 Receptor Binding	Nucleotide Binding Microtubule Motor Activity Protein Binding ATP Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Microtubule Binding Lipid Binding Plus-end-directed Microtubule Motor Activity ATP Hydrolysis Activity Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-3,4-bisphosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding
	Biological Process	Immune System Process Chemotaxis Immune Response Cytokine-mediated Signaling Pathway Leukocyte Chemotaxis Positive Regulation Of Interleukin-1 Alpha Production Positive Regulation Of Interleukin-12 Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Inflammatory Response Induction Of Positive Chemotaxis Regulation Of Calcium Ion Transport Positive Regulation Of Neutrophil Activation	Formation Of Primary Germ Layer Regulation Of Receptor Recycling Golgi To Endosome Transport Microtubule-based Movement Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Epidermal Growth Factor Receptor Signaling Pathway Endoderm Development Fibroblast Growth Factor Receptor Signaling Pathway Vesicle-mediated Transport Receptor Catabolic Process Early Endosome To Late Endosome Transport Vesicle Transport Along Microtubule
Pathways		Other interleukin signaling	COPI-dependent Golgi-to-ER retrograde traffic Kinesins
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Blood protein levels ( 30072576) Blood protein levels in cardiovascular risk ( 28369058) Body mass index ( 26426971) Brown vs. black hair color ( 30531825) Colorectal cancer (aspirin and/or NSAID use interaction) ( 25781442) Height ( 31562340) Inattentive symptoms ( 18821565) Interleukin-16 levels ( 27989323) Lymphocyte count ( 32888494) Primary biliary cholangitis ( 28425483)	Adult body size ( 32376654) Adventurousness ( 30643258) Alanine aminotransferase levels in non-alcoholic fatty liver disease ( 31311600) Asthma ( 27611488) Body mass index ( 26426971) Chronotype ( 30696823) Dimensional psychopathology (Positive) ( 29496196) Emphysema imaging phenotypes ( 26030696) Gut microbiota alpha diversity (Chao1 index) ( 33208821) Gut microbiota alpha diversity (PD_whole_tree index) ( 33208821) Gut microbiota alpha diversity (Shannon index) ( 33208821) Gut microbiota relative abundance (unclassified genus belonging to family Ruminococcaceae) ( 33208821) HDL cholesterol levels in HIV infection ( 33109212) Hodgkin's lymphoma ( 34216518) Ileal carcinoids ( 21139019) Intelligence ( 22449649) LDL cholesterol levels in HIV infection ( 33109212) Lipid traits ( 30576415) Platelet distribution width ( 32888494) Plateletcrit ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Sweet taste preference ( 32572145)
Interacting Genes		108 interacting genes: ANXA6 BLZF1 BOLA2 BOLA2B CALCOCO2 CAMK1 CARD10 CASP3 CCDC184 CCDC33 CD4 CDK1 CEP72 CSNK2A1 CSNK2A2 CYSRT1 DMRTB1 DUSP7 EFEMP2 FAM124A FHL2 FHL5 FTO GABPB1 GOLGA2 GOLGA6L9 GRIN2A GRIN2B GRIN2C GRIN2D HDAC3 HOMEZ HOOK2 HSF2BP JAKMIP1 KANK2 KCNA3 KCND1 KCND2 KCNJ10 KCNJ15 KCNJ2 KCNJ4 KCTD9 KDM1A KIF16B KIFC3 KRT31 KRT86 KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP3-1 L3MBTL3 LGALS14 LMO3 LNX1 LNX2 MBD3L1 MID2 MIER2 MTUS2 MYOG NOXA1 NTAQ1 OIP5 PDLIM7 PFDN5 PICK1 PPP1R12A PPP1R12B PPP1R12C PPP1R16A PRDM6 PRR13 PSTPIP1 RAPGEF2 RBCK1 RNF144B SERTAD3 SMARCB1 SOHLH1 SPRED1 SUV39H1 TEPSIN TFIP11 TRIB3 TRIM23 TRIM27 TRIM42 TRIP6 UBXN11 USHBP1 WWTR1 ZBTB39 ZIM2 ZNF143 ZNF165 ZNF474 ZNF526 ZNF572 ZNF581 ZNF620 ZNF774 ZNF777 ZNF835 ZNRD2 ZRANB1	10 interacting genes: GABARAPL2 GINS4 IL16 ITSN1 LGALS3 PRKAA1 PRKAA2 SMYD1 TCEANC TSR2
Entrez ID		3603	55614
HPRD ID		04329	10731
Ensembl ID		ENSG00000172349	ENSG00000089177
Uniprot IDs		A0A8C8KBU6 Q14005 Q9UME6	A0A140VK74 A0A1B0GTU3 A0A1B0GVS8 Q96L93
PDB IDs		1I16 1X6D 5FB8	2V14 6EE0
Enriched GO Terms of Interacting Partners?		Protein Binding Myosin Phosphatase Regulator Activity NMDA Glutamate Receptor Activity NMDA Selective Glutamate Receptor Complex Excitatory Chemical Synaptic Transmission Ligand-gated Monoatomic Ion Channel Activity Zinc Ion Binding Identical Protein Binding Phosphatase Regulator Activity Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Inward Rectifier Potassium Channel Activity Regulation Of Transcription By RNA Polymerase II Monoatomic Ion Channel Complex Glutamate-gated Calcium Ion Channel Activity Keratin Filament Regulation Of RNA Metabolic Process Regulation Of Neuronal Synaptic Plasticity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Excitatory Postsynaptic Potential Positive Regulation Of Synaptic Transmission, Glutamatergic Potassium Ion Transmembrane Transport Monoatomic Ion Channel Activity Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Monoatomic Ion Transmembrane Transport Protein Kinase CK2 Complex Directional Locomotion Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential Postsynaptic Membrane Potassium Ion Transport Negative Regulation Of Transcription Initiation-coupled Chromatin Remodeling Ligand-gated Ion Channel Signaling Pathway Potassium Channel Activity Voltage-gated Potassium Channel Complex Synaptic Transmission, Glutamatergic Potassium Ion Import Across Plasma Membrane PDZ Domain Binding Regulation Of Primary Metabolic Process Protein Complex Oligomerization Stress Fiber A-type (transient Outward) Potassium Channel Activity Metal Ion Binding Modulation Of Excitatory Postsynaptic Potential Glutamate Receptor Signaling Pathway Regulation Of Synaptic Plasticity Transcription Corepressor Activity Metal Ion Transport Muscle Cell Development Long-term Synaptic Potentiation Regulation Of Postsynaptic Membrane Potential	Histone H2BS36 Kinase Activity [hydroxymethylglutaryl-CoA Reductase (NADPH)] Kinase Activity Protein Localization To Lipid Droplet Negative Regulation Of Tubulin Deacetylation Regulation Of Tubulin Deacetylation Negative Regulation Of Hepatocyte Apoptotic Process AMP-activated Protein Kinase Activity Lipid Droplet Disassembly Phosphatidylethanolamine Biosynthetic Process Regulation Of Protein Deacetylation Regulation Of Stress Granule Assembly Nucleotide-activated Protein Kinase Complex Fatty Acid Homeostasis Hepatocyte Apoptotic Process Cellular Response To Prostaglandin E Stimulus Phosphatidylcholine Biosynthetic Process Positive Regulation Of Glycolytic Process Protein K6-linked Ubiquitination Response To Prostaglandin E Positive Regulation Of Release Of Cytochrome C From Mitochondria Cellular Response To Prostaglandin Stimulus Negative Regulation Of Epithelial Cell Apoptotic Process Phosphatidylethanolamine Metabolic Process Cellular Response To Starvation Cholesterol Biosynthetic Process Positive Regulation Of ATP Metabolic Process Lipid Droplet Organization Response To Starvation Sterol Biosynthetic Process Regulation Of Release Of Cytochrome C From Mitochondria Epithelial Cell Apoptotic Process Negative Regulation Of Translational Initiation Positive Regulation Of Translational Initiation Cellular Response To Glucose Starvation Cellular Response To Nutrient Levels Regulation Of Glycolytic Process Regulation Of Epithelial Cell Apoptotic Process Protein Localization To Lysosome Cellular Response To Amino Acid Starvation Negative Regulation Of TORC1 Signaling Regulation Of Carbohydrate Catabolic Process Cellular Response To Xenobiotic Stimulus Autophagy Negative Regulation Of Glucosylceramide Biosynthetic Process Cellular Response To Glucose Stimulus Response To Amino Acid Starvation Positive Regulation Of TORC1 Signaling Phosphatidylcholine Metabolic Process TORC1 Signaling Energy Homeostasis
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