HACD1 and TMEM106C

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HACD1	TMEM106C
Description		3-hydroxyacyl-CoA dehydratase 1	transmembrane protein 106C
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding Hydroxyapatite Binding Very-long-chain (3R)-3-hydroxyacyl-CoA Dehydratase Activity	Protein Binding
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Sphingolipid Biosynthetic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Protein-containing Complex Assembly Cementum Mineralization
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS			Lymphocyte percentage of white cells ( 32888494) Metabolite levels ( 23823483)
Interacting Genes		7 interacting genes: CPLX4 IL10RA LMNA RNF170 TECR TMEM106C UBC	41 interacting genes: ADAM33 AIG1 BNIP3 C14orf180 CLDN19 CMTM7 CTXN3 CXCL9 EDDM3B FAXDC2 GOSR2 HACD1 IGFBP5 JAGN1 KRT31 KRTAP10-3 MAL MARCHF2 MYADM NKG7 NRSN1 PGA4 PLN PLP1 PLPP6 PTTG1IP RPRM SEC22A SERP2 SFTPC SMAGP TMEM106B TMEM11 TMEM218 TMEM35A TMEM97 TSPAN33 UPK2 VAMP5 YIPF6 ZFPL1
Entrez ID		9200	79022
HPRD ID		10175	14690
Ensembl ID		ENSG00000165996	ENSG00000134291
Uniprot IDs		B0YJ81	Q9BVX2
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Interleukin-10 Binding Pro-T Cell Differentiation Parathyroid Hormone Secretion Interleukin-10 Receptor Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Endoplasmic Reticulum Membrane Very-long-chain Enoyl-CoA Reductase Activity	Membrane Endoplasmic Reticulum Membrane Endoplasmic Reticulum Multivesicular Body Lumen
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