HACD1 and RNF170

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		HACD1	RNF170
Description		3-hydroxyacyl-CoA dehydratase 1	ring finger protein 170
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Binding Lyase Activity 3-hydroxyacyl-CoA Dehydratase Activity Enzyme Binding Hydroxyapatite Binding Very-long-chain (3R)-3-hydroxyacyl-CoA Dehydratase Activity	Protein Binding Zinc Ion Binding Transferase Activity Metal Ion Binding Ubiquitin Protein Ligase Activity
	Biological Process	Lipid Metabolic Process Fatty Acid Metabolic Process Fatty Acid Biosynthetic Process Positive Regulation Of Cell-substrate Adhesion Sphingolipid Biosynthetic Process Fatty Acid Elongation Long-chain Fatty-acyl-CoA Biosynthetic Process Very Long-chain Fatty Acid Biosynthetic Process Protein-containing Complex Assembly Cementum Mineralization	Protein Polyubiquitination Adult Walking Behavior Response To Temperature Stimulus Gene Expression Proteasomal Protein Catabolic Process Response To Activity Protein Ubiquitination Protein Catabolic Process Toll-like Receptor 3 Signaling Pathway Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Innate Immune Response Protein K48-linked Ubiquitination Walking Behavior
Pathways		Synthesis of very long-chain fatty acyl-CoAs
Drugs
Diseases
GWAS
Interacting Genes		7 interacting genes: CPLX4 IL10RA LMNA RNF170 TECR TMEM106C UBC	15 interacting genes: DNAJC30 FXYD6-FXYD2 HACD1 PLPP6 PSMA6 SGTA SGTB SNAP47 STARD3 TMEM109 TMEM97 UBE2D2 UBE2L3 UBE2U UPK2
Entrez ID		9200	81790
HPRD ID		10175	13165
Ensembl ID		ENSG00000165996	ENSG00000120925
Uniprot IDs		B0YJ81	Q96K19
PDB IDs
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Response To X-ray Negative Regulation Of Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Type IV Hypersensitivity Negative Regulation Of Fibroblast Growth Factor Receptor Signaling Pathway Involved In Ureteric Bud Formation Negative Regulation Of Cell Proliferation Involved In Mesonephros Development Interleukin-10 Binding Pro-T Cell Differentiation Parathyroid Hormone Secretion Interleukin-10 Receptor Activity DNA Double-strand Break Attachment To Nuclear Envelope Structural Constituent Of Nuclear Lamina Endoplasmic Reticulum Membrane Very-long-chain Enoyl-CoA Reductase Activity	TRC Complex Ubiquitin Conjugating Enzyme Activity Protein Targeting To Membrane Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Ubiquitin-like Protein Transferase Activity Proteolysis Involved In Protein Catabolic Process Protein Targeting To ER Establishment Of Protein Localization To Endoplasmic Reticulum Purine Ribonucleoside Triphosphate Binding Establishment Of Protein Localization To Membrane Protein Targeting Cholesterol Binding Isoprenoid Diphosphate Phosphatase Activity Farnesyl Diphosphate Catabolic Process Geranylgeranyl Diphosphate Catabolic Process
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