IL10 and IL10RA

Number of citations of the paper that reports this interaction (PMID 8248239)
37

Data Source:
HPRD (in vitro, in vivo)

		IL10	IL10RA
Gene Name		interleukin 10	interleukin 10 receptor, alpha
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space	Plasma Membrane Integral Component Of Membrane
	Molecular Function	Cytokine Activity Interleukin-10 Receptor Binding Growth Factor Activity	Signal Transducer Activity Receptor Activity Interleukin-10 Receptor Activity Protein Binding Interleukin-10 Binding
	Biological Process	Response To Molecule Of Bacterial Origin Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Inflammatory Response Cytoplasmic Sequestering Of NF-kappaB Cell-cell Signaling Aging Regulation Of Gene Expression Response To Activity Response To Inactivity Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Receptor Biosynthetic Process Response To Insulin Response To Carbon Monoxide Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Response To Drug Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Cytokine Secretion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Glucocorticoid Regulation Of Sensory Perception Of Pain Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process	Cytokine-mediated Signaling Pathway Response To Lipopolysaccharide
Pathways
Drugs
Diseases
GWAS		Behcet's disease ( 20622878 20622879) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Type 1 diabetes ( 19430480) Type 1 diabetes autoantibodies ( 21829393) Ulcerative colitis ( 19915572 20228798 20228799 18836448 21297633)	Obesity-related traits ( 23251661)
Protein-Protein Interactions		3 interactors: A2M IL10RA IL10RB	3 interactors: IL10 IL10RB JAK1
Entrez ID		3586	3587
HPRD ID		00495	00911
Ensembl ID		ENSG00000136634	ENSG00000110324
Uniprot IDs		P22301 Q6FGW4	Q13651
PDB IDs		1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK	1J7V 1LQS 1Y6K 1Y6M 1Y6N
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Complement Activation, Lectin Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Blood Coagulation, Intrinsic Pathway Negative Regulation Of Complement Activation Response To Cytokine Response To Other Organism Response To Biotic Stimulus Regulation Of Complement Activation Negative Regulation Of Innate Immune Response Regulation Of Humoral Immune Response	Negative Regulation Of Interferon-alpha Biosynthetic Process Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Immune Response Defense Response Interleukin-2-mediated Signaling Pathway Response To Carbon Monoxide Negative Regulation Of Myeloid Dendritic Cell Activation Cellular Response To Organic Substance Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Positive Regulation Of B Cell Apoptotic Process Negative Regulation Of Membrane Protein Ectodomain Proteolysis Negative Regulation Of MHC Class II Biosynthetic Process Regulation Of Myeloid Dendritic Cell Activation Immune System Process Receptor Biosynthetic Process Cytoplasmic Sequestering Of NF-kappaB Negative Regulation Of Chronic Inflammatory Response Negative Regulation Of Cytokine Secretion Involved In Immune Response Positive Regulation Of MHC Class II Biosynthetic Process Inflammatory Response Cytokine-mediated Signaling Pathway Type 2 Immune Response Response To Organic Substance Response To Interleukin-2 Branching Involved In Labyrinthine Layer Morphogenesis Response To Inactivity Negative Regulation Of Inflammatory Response To Antigenic Stimulus Regulation Of Cytokine Secretion Involved In Immune Response Regulation Of Chronic Inflammatory Response Cellular Response To Cytokine Stimulus Negative Regulation Of Nitric Oxide Biosynthetic Process Negative Regulation Of B Cell Proliferation Negative Regulation Of Reactive Oxygen Species Biosynthetic Process Negative Regulation Of NF-kappaB Import Into Nucleus Regulation Of B Cell Apoptotic Process Regulation Of Tumor Necrosis Factor Biosynthetic Process Cellular Response To Estradiol Stimulus Positive Regulation Of Lymphocyte Apoptotic Process Response To Cytokine Response To Other Organism Negative Regulation Of Interleukin-12 Production Cytoplasmic Sequestering Of Transcription Factor Regulation Of Interferon-gamma-mediated Signaling Pathway Regulation Of Response To Interferon-gamma Labyrinthine Layer Morphogenesis Response To Biotic Stimulus Cytoplasmic Sequestering Of Protein Response To Stress Regulation Of Sensory Perception Of Pain Negative Regulation Of Growth Of Symbiont In Host
Tagcloud ?		30min ancestry asks asleep habitual ifng ifngr1 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Difference) ?		30min ancestry asks asleep habitual ifng ifngr1 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender	bioinformatics bmp2 calm1 cnaq csf2rb csf3 expressions fifteen gria2 il3ra il6st lifr lymphatic microarrays myl9 mylk myosin nonsmokers nsclc paraneoplastic pathohistological plcb4 ppp2ca rac3 rock2 thbs1 verify
Tagcloud (Intersection) ?