IL10 and KRTAP4-1

Number of citations: 50 (PubMedID 32296183)
Data Source: BioGRID (two hybrid)

		IL10	KRTAP4-1
Name		interleukin 10	keratin associated protein 4-1
Structure			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytosol Intermediate Filament Keratin Filament
	Molecular Function	Cytokine Activity Interleukin-10 Receptor Binding Protein Binding Growth Factor Activity Protein Dimerization Activity	Protein Binding
	Biological Process	Negative Regulation Of Cytokine Production Positive Regulation Of Cytokine Production Positive Regulation Of Endothelial Cell Proliferation Response To Molecule Of Bacterial Origin Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of Immunoglobulin Production Negative Regulation Of Cytokine Production Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Immune Response Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of Gene Expression Negative Regulation Of Autophagy Response To Activity Response To Inactivity Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Response To Lipopolysaccharide Negative Regulation Of Interferon-alpha Production Negative Regulation Of Type II Interferon Production Negative Regulation Of Interleukin-1 Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-18 Production Negative Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-8 Production Negative Regulation Of Tumor Necrosis Factor Production Response To Insulin Negative Regulation Of Heterotypic Cell-cell Adhesion Positive Regulation Of Heterotypic Cell-cell Adhesion Response To Carbon Monoxide Cellular Response To Hepatocyte Growth Factor Stimulus Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Defense Response To Bacterium Defense Response To Protozoan Positive Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of Cell Cycle Positive Regulation Of DNA-templated Transcription Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Negative Regulation Of Inflammatory Response Regulation Of Synapse Organization Negative Regulation Of Membrane Protein Ectodomain Proteolysis Response To Glucocorticoid Negative Regulation Of Cytokine Activity Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Negative Regulation Of Chemokine (C-C Motif) Ligand 5 Production Endothelial Cell Apoptotic Process Liver Regeneration Interleukin-10-mediated Signaling Pathway Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of MiRNA Transcription Regulation Of Response To Wounding Negative Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Sprouting Angiogenesis Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Positive Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process	None
Pathways		Interleukin-10 signaling Interleukin-4 and Interleukin-13 signaling Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation CD163 mediating an anti-inflammatory response FCGR3A-mediated IL10 synthesis Signaling by ALK fusions and activated point mutants	Keratinization
Drugs		CRx-139 LLL-3348	None
Diseases		Graft-versus-host disease Allograft rejection	None
GWAS		Acute anterior uveitis (with or without ankylosing spondylitis) ( 25200001 ) Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297 ) Behcet's disease ( 33393726 20622878 20622879 ) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007 ) Crohn's disease ( 21102463 28067908 ) Gut microbiota (functional units) ( 27694959 ) Inflammatory bowel disease ( 28067908 28008999 23128233 ) Itch intensity from mosquito bite ( 28199695 ) Mosquito bite size ( 28199695 ) Pediatric autoimmune diseases ( 26301688 ) Systemic lupus erythematosus ( 26502338 28714469 19838195 ) Type 1 diabetes ( 25751624 21829393 30572963 19430480 ) Ulcerative colitis ( 26398853 18836448 21297633 20228799 28067908 20228798 19915572 )	No GWAS studies recorded
Novel Interactors		2 novel interactors: PTPRC TNFSF4	None recorded
Interacting Genes		12 interacting genes: A2M GLRX3 IL10RA IL10RB KRTAP1-3 KRTAP10-8 KRTAP4-1 NBPF19 NOTCH2NLA S100A6 S100P YY1	29 interacting genes: CATSPER1 CRCT1 CREB5 DHRS1 FBXW5 GNE HOXA1 IL10 KRTAP5-6 KRTAP9-3 KRTAP9-8 LCE1A LCE1B LCE1D LCE1F LCE2C LCE2D LCE3A LCE3C LCE3D LCE3E LCE5A NECTIN3 NPDC1 NUFIP2 OTX1 PSMA1 SMCP VASN
Entrez ID		3586	85285
HPRD ID		00495	13940
Ensembl ID		ENSG00000136634	ENSG00000198443
Uniprot IDs		A0A286YEX3 P22301 Q6FGW4	Q9BYQ7
PDB IDs		1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK 6X93 8SVE	Not available
GO Terms Enriched among Interactors		Interleukin-10 Receptor Activity Calcium-dependent Protein Binding Interleukin-10-mediated Signaling Pathway Regulation Of Receptor Signaling Pathway Via JAK-STAT Keratin Filament Positive Regulation Of Alpha-beta T Cell Proliferation Positive Regulation Of Isotype Switching Intermediate Filament Regulation Of Humoral Immune Response Negative Regulation Of Immune Response Positive Regulation Of Receptor Signaling Pathway Via JAK-STAT Positive Regulation Of Receptor Signaling Pathway Via STAT Interleukin-10 Binding Regulation Of Isotype Switching Positive Regulation Of Immunoglobulin Mediated Immune Response Plasma Membrane Raft Distribution Positive Regulation Of Interleukin-4-dependent Isotype Switching To IgE Isotypes Positive Regulation Of CD4-positive, Alpha-beta T Cell Costimulation T-helper 2 Cell Activation Response To Nitrogen Dioxide Negative Regulation Of Muscle Hypertrophy Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Immunoglobulin Production Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Defense Response Negative Regulation Of Interleukin-4-mediated Signaling Pathway Negative Regulation Of Adaptive Immune Response Positive Regulation Of Hematopoietic Stem Cell Migration Positive Regulation Of DNA Metabolic Process Positive Regulation Of T Cell Mediated Immunity Memory T Cell Activation Positive Regulation Of T Cell Costimulation Immunoglobulin Heavy Chain V-D-J Recombination Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Alpha-beta T Cell Activation Positive Regulation Of DNA Recombination Regulation Of Immunoglobulin Production Interleukin-8 Binding Interleukin-28 Receptor Complex Membrane Microdomain Negative Regulation Of Cytokine Production Positive Regulation Of B Cell Activation Defense Response To Nematode Response To Prostaglandin F Response To Lipid Alpha-beta T Cell Activation DN2 Thymocyte Differentiation Regulation Of T Cell Mediated Immunity Negative Regulation Of Cell Adhesion Involved In Substrate-bound Cell Migration Negative Regulation Of T-helper 1 Cell Differentiation	Keratinization Epidermis Development Tissue Development