IL10

Gene Name		interleukin 10
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space
	Molecular Function	Cytokine Activity Interleukin-10 Receptor Binding Growth Factor Activity
	Biological Process	Response To Molecule Of Bacterial Origin Negative Regulation Of Cytokine Secretion Involved In Immune Response Negative Regulation Of Chronic Inflammatory Response To Antigenic Stimulus Positive Regulation Of B Cell Apoptotic Process Inflammatory Response Cytoplasmic Sequestering Of NF-kappaB Cell-cell Signaling Aging Regulation Of Gene Expression Response To Activity Response To Inactivity Hemopoiesis B Cell Differentiation Leukocyte Chemotaxis Negative Regulation Of Myeloid Dendritic Cell Activation Negative Regulation Of B Cell Proliferation Negative Regulation Of Interferon-gamma Production Negative Regulation Of Interleukin-12 Production Negative Regulation Of Interleukin-6 Production Receptor Biosynthetic Process Response To Insulin Response To Carbon Monoxide Type 2 Immune Response B Cell Proliferation Negative Regulation Of T Cell Proliferation Response To Drug Negative Regulation Of Tumor Necrosis Factor Biosynthetic Process Defense Response To Bacterium Negative Regulation Of Apoptotic Process Negative Regulation Of Growth Of Symbiont In Host Negative Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Isotype Switching Negative Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of MHC Class II Biosynthetic Process Negative Regulation Of Interferon-alpha Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of JAK-STAT Cascade Positive Regulation Of Cytokine Secretion Negative Regulation Of Membrane Protein Ectodomain Proteolysis Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Response To Glucocorticoid Regulation Of Sensory Perception Of Pain Branching Involved In Labyrinthine Layer Morphogenesis Cellular Response To Lipopolysaccharide Cellular Response To Estradiol Stimulus Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Behcet's disease ( 20622878 20622879) Crohn's disease ( 21102463) Inflammatory bowel disease ( 23128233) Type 1 diabetes ( 19430480) Type 1 diabetes autoantibodies ( 21829393) Ulcerative colitis ( 19915572 20228798 20228799 18836448 21297633)
Protein-protein Interactions		3 interactors: A2M IL10RA IL10RB
Entrez ID		3586
HPRD ID		00495
Ensembl ID		ENSG00000136634
Uniprot IDs		P22301 Q6FGW4
PDB IDs		1ILK 1INR 1J7V 1LK3 1Y6K 2H24 2ILK
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Complement Activation, Lectin Pathway Cytokine-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Blood Coagulation, Intrinsic Pathway Negative Regulation Of Complement Activation Response To Cytokine Response To Other Organism Response To Biotic Stimulus Regulation Of Complement Activation Negative Regulation Of Innate Immune Response Regulation Of Humoral Immune Response
Tagcloud ?		30min ancestry asks asleep habitual ifng ifngr1 il13 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender