G3BP1 and LGALS8

Number of citations of the paper that reports this interaction (PubMedID 36179369)
99

Data Source:
BioGRID (pull down)

		G3BP1	LGALS8
Description		G3BP stress granule assembly factor 1	galectin 8
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Focal Adhesion Cytoplasmic Stress Granule Perikaryon	Extracellular Space Cytoplasm Cytosol Membrane Cytoplasmic Vesicle
	Molecular Function	Nucleotide Binding Nucleic Acid Binding DNA Binding DNA Helicase Activity RNA Binding RNA Helicase Activity MRNA Binding Helicase Activity Nuclease Activity Endonuclease Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity DNA/RNA Helicase Activity Ribosomal Small Subunit Binding Molecular Condensate Scaffold Activity	Integrin Binding Protein Binding Carbohydrate Binding
	Biological Process	Immune System Process Ras Protein Signal Transduction Positive Regulation Of Type I Interferon Production Stress Granule Assembly Innate Immune Response Defense Response To Virus Positive Regulation Of Stress Granule Assembly Negative Regulation Of Canonical Wnt Signaling Pathway	Plasma Cell Differentiation Autophagy T Cell Costimulation Cellular Response To Virus Xenophagy Lymphatic Endothelial Cell Migration
Pathways		SARS-CoV-2 activates/modulates innate and adaptive immune responses
Drugs
Diseases
GWAS		Periventricular white matter hyperintensities ( 32517579) Platelet distribution width ( 32888494) Red cell distribution width ( 32888494)	Platelet count ( 32888494) Platelet distribution width ( 32888494) Plateletcrit ( 32888494)
Interacting Genes		23 interacting genes: APP CEBPA CSK DTX1 EPHA8 FBXO25 GABARAP GABARAPL1 IL7R LCK LGALS8 LINC01554 OGT PIN1 PPIA RASA1 SPOP TRIM21 TRIM25 UBAP2L USP10 USP13 USP2	22 interacting genes: ANXA1 APEH BARD1 CALCOCO2 ERBB2 G3BP1 ITGA3 ITGA4 ITGB1 LRRK2 MEFV MID2 NACC1 NR1D2 NUFIP2 TRIM17 TRIM22 TRIM23 TRIM49 TRIM5 TRIM6 WBP2
Entrez ID		10146	3964
HPRD ID		06569	09356
Ensembl ID		ENSG00000145907	ENSG00000116977
Uniprot IDs		Q13283 Q5U0Q1 Q6ZP53	O00214
PDB IDs		3Q90 4FCJ 4FCM 4IIA 5FW5 6TA7 7S17 7SUO 7XHF 7XHG 8TH1 8TH5 8TH6 8TH7 8V1L	2YRO 2YV8 2YXS 3AP4 3AP5 3AP6 3AP7 3AP9 3APB 3OJB 3VKL 3VKM 3VKN 3VKO 4BMB 4BME 4FQZ 4GXL 4HAN 5GZC 5GZD 5GZE 5GZF 5GZG 5T7I 5T7S 5T7T 5T7U 5VWG 6W4Z 6Z6Y 7AEN 7ALS 7P1M 8CM8 8HL9 9FYJ
Enriched GO Terms of Interacting Partners?		Protein Modification Process Regulation Of Intracellular Signal Transduction Ubiquitin Protein Ligase Binding Autophagy Protein Peptidyl-prolyl Isomerization Regulation Of Signal Transduction Positive Regulation Of Proteolysis Regulation Of Protein Catabolic Process Cytoplasm Stress Granule Assembly Regulation Of Proteolysis Positive Regulation Of Cell Activation Post-translational Protein Modification Cellular Developmental Process Protein Metabolic Process Regulation Of Protein K48-linked Ubiquitination Regulation Of Cell Activation Regulation Of Cell Communication Regulation Of Signaling T Cell Costimulation Heparan Sulfate Binding Organelle Assembly Protein Monoubiquitination Mitophagy Cellular Response To Nitrogen Starvation Macroautophagy Regulation Of Stress Granule Assembly Mononuclear Cell Differentiation Cysteine-type Endopeptidase Activity Hemopoiesis Macromolecule Metabolic Process Response To Cytokine Regulation Of Cell Adhesion Positive Regulation Of Protein Metabolic Process Response To Peptide Neuron Remodeling Autophagy Of Mitochondrion Phosphatidylethanolamine Binding Intracellular Signal Transduction Regulation Of Protein Stability Leukocyte Differentiation Regulation Of Proteasomal Protein Catabolic Process Autophagosome Positive Regulation Of Protein Catabolic Process Regulation Of Leukocyte Cell-cell Adhesion Protein Ubiquitination Suppression Of Viral Release By Host GABA Receptor Binding Regulation Of T Cell Activation Regulation Of Protein Metabolic Process	Ubiquitin Protein Ligase Activity Innate Immune Response Immune System Process Defense Response To Symbiont Defense Response To Other Organism Positive Regulation Of Autophagy Immune Response Positive Regulation Of Metabolic Process Defense Response Regulation Of Metabolic Process Response To Other Organism Integrin Alpha3-beta1 Complex Response To External Biotic Stimulus Integrin Alpha4-beta1 Complex Metal Ion Binding Positive Regulation Of Catabolic Process Integrin Complex Positive Regulation Of Macromolecule Metabolic Process Cytoplasm Response To Stress Regulation Of Autophagy Fibronectin Binding Protein Ubiquitination Zinc Ion Binding Regulation Of Protein Localization C-X3-C Chemokine Binding Protein Modification Process Protein Modification By Small Protein Conjugation Regulation Of Gene Expression Positive Regulation Of Macromolecule Biosynthetic Process Defense Response To Virus Cell-cell Adhesion Mediated By Integrin Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Positive Regulation Of Biosynthetic Process Coreceptor Activity Regulation Of Defense Response Post-translational Protein Modification Positive Regulation Of Gene Expression Regulation Of Intracellular Signal Transduction Negative Regulation Of Vasoconstriction Response To Virus Neuromuscular Junction Mesodermal Cell Differentiation Protein-macromolecule Adaptor Activity Focal Adhesion Transferase Activity Regulation Of Rho Protein Signal Transduction Suppression Of Viral Release By Host Positive Regulation Of Immune System Process
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