IL4 and IL13

Number of citations of the paper that reports this interaction (PMID 8609418)
25

Data Source:
BioGRID (pull down)

		IL4	IL13
Gene Name		interleukin 4	interleukin 13
Image
Gene Ontology Annotations	Cellular Component	Extracellular Space External Side Of Plasma Membrane	Extracellular Region Extracellular Space Cytoplasm External Side Of Plasma Membrane
	Molecular Function	Cytokine Activity Interleukin-4 Receptor Binding Protein Binding Growth Factor Activity	Cytokine Activity Interleukin-13 Receptor Binding Protein Binding
	Biological Process	Microglial Cell Activation Innate Immune Response In Mucosa Positive Regulation Of Defense Response To Virus By Host T-helper 1 Cell Lineage Commitment Negative Regulation Of Acute Inflammatory Response Negative Regulation Of Chronic Inflammatory Response Chemotaxis Immune Response Cellular Defense Response Female Pregnancy Response To Nutrient Cholesterol Metabolic Process Regulation Of Proton Transport Response To Organic Cyclic Compound B Cell Differentiation Positive Regulation Of B Cell Proliferation B Cell Costimulation Positive Regulation Of Interleukin-10 Production Positive Regulation Of Interleukin-13 Production Response To Cytokine T-helper 2 Cell Cytokine Production Type 2 Immune Response Positive Regulation Of T Cell Proliferation Positive Regulation Of Activated T Cell Proliferation B Cell Activation Regulation Of Phosphorylation Response To Drug Positive Regulation Of Tyrosine Phosphorylation Of Stat5 Protein Defense Response To Protozoan Negative Regulation Of Macrophage Activation Negative Regulation Of Apoptotic Process Negative Regulation Of Nitric Oxide Biosynthetic Process T-helper 2 Cell Differentiation Positive Regulation Of Chemokine Biosynthetic Process Connective Tissue Growth Factor Biosynthetic Process Regulation Of Isotype Switching Positive Regulation Of MHC Class II Biosynthetic Process Response To Ethanol Positive Regulation Of T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription From RNA Polymerase II Promoter Positive Regulation Of Isotype Switching To IgE Isotypes Positive Regulation Of Isotype Switching To IgG Isotypes Regulation Of Immune Response Positive Regulation Of Sequence-specific DNA Binding Transcription Factor Activity Retina Development In Camera-type Eye Cellular Response To Mercury Ion Positive Regulation Of Mononuclear Cell Migration Dendritic Cell Differentiation Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of T-helper 17 Cell Differentiation Negative Regulation Of Endothelial Cell Apoptotic Process Positive Regulation Of Eosinophil Chemotaxis Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Microglial Cell Activation Positive Regulation Of Immunoglobulin Production Movement Of Cell Or Subcellular Component Inflammatory Response Immune Response Signal Transduction Cell-cell Signaling Regulation Of Proton Transport Positive Regulation Of B Cell Proliferation Response To Lipopolysaccharide Positive Regulation Of Connective Tissue Growth Factor Production Negative Regulation Of NAD(P)H Oxidase Activity Response To Nicotine Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Positive Regulation Of Macrophage Activation Response To Ethanol Positive Regulation Of Smooth Muscle Cell Proliferation Positive Regulation Of Protein Secretion Positive Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cellular Response To Mechanical Stimulus Cellular Response To Cytokine Stimulus Negative Regulation Of Transforming Growth Factor Beta Production Negative Regulation Of Neuron Death Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Lung Goblet Cell Differentiation Negative Regulation Of Complement-dependent Cytotoxicity Positive Regulation Of Pancreatic Stellate Cell Proliferation Negative Regulation Of Endothelial Cell Apoptotic Process
Pathways
Drugs
Diseases
GWAS		Inflammatory bowel disease ( 23128233)	Asthma ( 20860503) Atopic dermatitis ( 23042114) Hodgkin's lymphoma ( 22286212) IgE levels ( 22075330) Inflammatory bowel disease ( 23128233) Psoriasis ( 19169254)
Protein-Protein Interactions		7 interactors: A2M CD53 IL13 IL13RA2 IL2RG IL4R PIK3CD	6 interactors: IL13RA1 IL13RA2 IL4 IL4R PIK3R1 VCAM1
Entrez ID		3565	3596
HPRD ID		00989	00981
Ensembl ID		ENSG00000113520	ENSG00000169194
Uniprot IDs		D4HNR6 P05112 Q5FC01	P35225
PDB IDs		1BBN 1BCN 1CYL 1HIJ 1HIK 1HZI 1IAR 1ILL 1ITE 1ITI 1ITL 1ITM 1RCB 2B8U 2B8X 2B8Y 2B8Z 2B90 2B91 2CYK 2D48 2INT 3BPL 3BPN 3QB7	1GA3 1IJZ 1IK0 1J9U 3BPO 3G6D 3ITR 3ITS 3L5W 3L5X 3L5Y 3LB6 4I77
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Macrophage Activation Interleukin-4-mediated Signaling Pathway Cellular Response To Cytokine Stimulus Regulation Of Macrophage Activation Response To Cytokine Signal Transduction Signaling Cell Communication Cellular Response To Organic Substance Cellular Response To Interleukin-4 Response To Interleukin-4 Cellular Response To Stimulus Inflammatory Response Cytokine-mediated Signaling Pathway Response To Organic Substance Immune Response Regulation Of Immune System Process Positive Regulation Of Connective Tissue Growth Factor Production Positive Regulation Of Lung Goblet Cell Differentiation Positive Regulation Of Tyrosine Phosphorylation Of Stat6 Protein Negative Regulation Of Lung Ciliated Cell Differentiation Positive Regulation Of Pancreatic Stellate Cell Proliferation Interleukin-7-mediated Signaling Pathway Negative Regulation Of Complement Activation, Lectin Pathway Negative Regulation Of Complement-dependent Cytotoxicity Regulation Of Complement-dependent Cytotoxicity Negative Regulation Of Immune Response Response To Stimulus Cell Activation Negative Regulation Of T-helper 1 Cell Differentiation Mast Cell Differentiation Negative Regulation Of NAD(P)H Oxidase Activity Natural Killer Cell Chemotaxis B Cell Chemotaxis Neutrophil Extravasation Interleukin-2-mediated Signaling Pathway Mast Cell Chemotaxis Positive Regulation Of Protein Secretion Respiratory Burst Involved In Defense Response Positive Regulation Of Cell Differentiation Regulation Of Immune Response Negative Regulation Of Transforming Growth Factor Beta Production Positive Regulation Of Immune System Process Immune System Process Regulation Of NAD(P)H Oxidase Activity Negative Regulation Of T-helper 1 Type Immune Response Positive Regulation Of Chemokine Secretion Regulation Of T-helper 1 Cell Differentiation T Cell Chemotaxis Negative Regulation Of T-helper Cell Differentiation	Positive Regulation Of Cell Activation Regulation Of Lymphocyte Activation Regulation Of Cell Activation Positive Regulation Of T Cell Activation Positive Regulation Of Homotypic Cell-cell Adhesion Response To Cytokine Positive Regulation Of Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Immune System Process Regulation Of Cell-cell Adhesion Positive Regulation Of Cell Adhesion B Cell Differentiation Response To Organic Substance Cytokine-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Negative Regulation Of T-helper Cell Differentiation Positive Regulation Of Mononuclear Cell Proliferation Regulation Of Immune System Process Negative Regulation Of Alpha-beta T Cell Differentiation Cellular Response To Cytokine Stimulus B Cell Activation Cell Surface Receptor Signaling Pathway Regulation Of Cell Adhesion Defense Response To Protozoan Negative Regulation Of Cell Adhesion Negative Regulation Of Alpha-beta T Cell Activation Regulation Of Macrophage Activation Response To Protozoan Cellular Response To Organic Substance Lymphocyte Differentiation Negative Regulation Of Osteoclast Differentiation Regulation Of Immune Response Regulation Of T-helper Cell Differentiation Negative Regulation Of T Cell Differentiation Negative Regulation Of Adaptive Immune Response Regulation Of CD4-positive, Alpha-beta T Cell Differentiation Positive Regulation Of Immunoglobulin Production Positive Regulation Of B Cell Proliferation Positive Regulation Of Chemokine Production Leukocyte Differentiation Negative Regulation Of Lymphocyte Differentiation Negative Regulation Of Myeloid Leukocyte Differentiation Positive Regulation Of Cytokine Production Negative Regulation Of Immune System Process Regulation Of Chemokine Production Regulation Of B Cell Proliferation Lymphocyte Activation Regulation Of Osteoclast Differentiation Immune Response Signal Transduction
Tagcloud ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il2 il4 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Difference) ?		abolished aerosols airway allergic antibodies asthma bal bronchoalveolar challenge challenged completely differentially directed eosinophil eosinophilia eosinophils gamma hyperresponsiveness ifn il5 infiltration lavage methacholine ovalbumin phenomena repeatedly sensitized subsequently tnf	30min ancestry asks asleep habitual ifng ifngr1 il10 il17a il1b il1r2 il2 il6 il8 interleukins nfkb1 nfkb2 pittsburgh rs1143623 rs1143642 rs1295686 rs2857602 rs4648110 rs4719714 soi strengthens tnfa transgender
Tagcloud (Intersection) ?		il4