SH3GL3 and ADRB1

Number of citations of the paper that reports this interaction (PMID 10535961)
17

Data Source:
HPRD (two hybrid)

		SH3GL3	ADRB1
Gene Name		SH3-domain GRB2-like 3	adrenoceptor beta 1
Image
Gene Ontology Annotations	Cellular Component	Early Endosome Membrane Extracellular Vesicular Exosome	Nucleus Early Endosome Plasma Membrane Integral Component Of Plasma Membrane
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	Beta-adrenergic Receptor Activity Beta1-adrenergic Receptor Activity Receptor Signaling Protein Activity Ras Guanyl-nucleotide Exchange Factor Activity Protein Binding Drug Binding PDZ Domain Binding Alpha-2A Adrenergic Receptor Binding Dopamine Binding Protein Heterodimerization Activity Epinephrine Binding Norepinephrine Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development	Positive Regulation Of Heart Rate By Epinephrine-norepinephrine Diet Induced Thermogenesis Vasodilation By Norepinephrine-epinephrine Involved In Regulation Of Systemic Arterial Blood Pressure Positive Regulation Of The Force Of Heart Contraction By Norepinephrine Positive Regulation Of Systemic Arterial Blood Pressure Glycogen Catabolic Process Apoptotic Process Activation Of Adenylate Cyclase Activity Rho Protein Signal Transduction Aging Memory Response To Cold Sensory Perception Of Pain Positive Regulation Of CAMP Biosynthetic Process Heat Generation Positive Regulation Of Ras GTPase Activity Protein Localization To Organelle Negative Regulation Of Urine Volume Negative Regulation Of Multicellular Organism Growth Wound Healing Fear Response Positive Regulation Of Apoptotic Process Positive Regulation Of CAMP-mediated Signaling Negative Regulation Of Smooth Muscle Contraction Positive Regulation Of Saliva Secretion Brown Fat Cell Differentiation Regulation Of Calcium Ion Transport Lipid Homeostasis Regulation Of Inhibitory Postsynaptic Membrane Potential Positive Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway Regulation Of Cardiac Muscle Cell Contraction Positive Regulation Of Renin Secretion Into Blood Stream Positive Regulation Of Cation Channel Activity
Pathways			Defective ACTH causes Obesity and Pro-opiomelanocortinin deficiency (POMCD) Signaling by GPCR GPCR downstream signaling G alpha (s) signalling events Adrenoceptors Class A/1 (Rhodopsin-like receptors) Amine ligand-binding receptors Metabolic disorders of biological oxidation enzymes GPCR ligand binding
Drugs			Esmolol Betaxolol Isoetharine Metoprolol Atenolol Norepinephrine Timolol Phenylpropanolamine Sotalol Carteolol Propranolol Labetalol Bisoprolol Epinephrine Dobutamine Pseudoephedrine Alprenolol Pindolol Salbutamol Isoproterenol Arbutamine Amiodarone Carvedilol Desipramine Acebutolol Nadolol Levobunolol Metipranolol Fenoterol Pirbuterol Bevantolol Practolol Penbutolol Ephedra Clenbuterol Oxprenolol Dronedarone Nebivolol Asenapine Droxidopa 4-{[(2S)-3-(tert-butylamino)-2-hydroxypropyl]oxy}-3H-indole-2-carbonitrile 2-HYDROXYMETHYL-6-OCTYLSULFANYL-TETRAHYDRO-PYRAN-3,4,5-TRIOL Bopindolol Bupranolol
Diseases
GWAS		Height ( 18391950 18391951 20397748)	Birth weight ( 23202124) Blood pressure ( 21909110) Gaucher disease severity ( 22388998)
Protein-Protein Interactions		44 interactors: ADRB1 AES ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNM1 DPPA4 DPYSL4 EGFL6 EMD FAM173A FASLG GABBR2 HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RBM48 RER1 RPL35A SEPT8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHC3 SNRPN SNX24 SYNJ1 TERF1 TNNT1 TOE1 VIM WASL WDR33	16 interactors: ADRA2A ARRB1 DLG1 DLG4 DLGAP2 GIPC1 GOPC GPRASP1 GPRASP2 GRB2 MAGI2 MAGI3 NOS1 SH3GL2 SH3GL3 SNTA1
Entrez ID		6457	153
HPRD ID		04528	00181
Ensembl ID		ENSG00000140600	ENSG00000043591
Uniprot IDs		Q99963	P08588
PDB IDs		2EW3 2Z0V	2LSQ
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Regulation Of Cellular Component Organization Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Signaling Regulation Of ERBB Signaling Pathway Enzyme Linked Receptor Protein Signaling Pathway Cell-cell Signaling Signal Transduction Vesicle-mediated Transport Cell Communication Movement Of Cell Or Subcellular Component Regulation Of Vesicle-mediated Transport Response To Stimulus Cellular Response To Stimulus Cell Death Death Positive Regulation Of Programmed Cell Death Positive Regulation Of Cell Death Membrane Organization Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Neuron Projection Morphogenesis Negative Regulation Of ERBB Signaling Pathway Endocytosis Transmembrane Receptor Protein Tyrosine Kinase Signaling Pathway Developmental Process System Development Neuron Development Apoptotic Process Cellular Process Generation Of Neurons Actin Filament-based Movement Multicellular Organismal Development Nervous System Development Programmed Cell Death Regulation Of Signaling Neurogenesis Regulation Of Endocytosis Regulation Of Signal Transduction Negative Regulation Of Neuron Differentiation Neuron Projection Development Establishment Of Vesicle Localization Synaptic Transmission Positive Regulation Of Apoptotic Process Cell Projection Morphogenesis Neuron Differentiation Vesicle Localization Response To Growth Factor Axon Guidance Neurotrophin TRK Receptor Signaling Pathway Cell Part Morphogenesis	Regulation Of Receptor Internalization Regulation Of Signal Transduction Regulation Of Vesicle-mediated Transport Negative Regulation Of Signal Transduction Regulation Of Signaling Negative Regulation Of Signaling Post-Golgi Vesicle-mediated Transport Negative Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Negative Regulation Of Adrenergic Receptor Signaling Pathway Regulation Of Sodium Ion Transmembrane Transport Regulation Of G-protein Coupled Receptor Protein Signaling Pathway Receptor Clustering Regulation Of Ion Transmembrane Transport Regulation Of Endocytosis Regulation Of Adrenergic Receptor Signaling Pathway Nucleotide Phosphorylation Signaling Regulation Of Cellular Component Organization Regulation Of Potassium Ion Transport Cell Communication Receptor Localization To Synapse Regulation Of Sodium Ion Transport Cell-cell Signaling Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of Phosphorus Metabolic Process Movement Of Cell Or Subcellular Component Intracellular Transport Regulation Of ERBB Signaling Pathway Positive Regulation Of Catalytic Activity Receptor Metabolic Process Golgi Vesicle Transport Synaptic Transmission Regulation Of Ion Transport Regulation Of Catalytic Activity Cellular Localization Endocytosis Regulation Of Intracellular Signal Transduction Protein Localization To Synapse Positive Regulation Of Transport Positive Regulation Of Receptor Internalization Locomotion Positive Regulation Of Signal Transduction Axon Guidance Positive Regulation Of Histone Acetylation Negative Regulation Of Transport Regulation Of Cellular Amino Acid Metabolic Process Regulation Of Cellular Protein Metabolic Process Regulation Of Ion Transmembrane Transporter Activity Positive Regulation Of Organelle Organization Regulation Of Transmembrane Transporter Activity
Tagcloud ?		85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish	alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Difference) ?		85k aorta cbl cin85 circulation circulatory cooperation da diameters dorsal endocytosis exerted impairing interacting lumen lumens morpholino morpholinos partner phosphatidylinositol shrinkage shrunken specification stereotyped studying unaffected vasculature zebrafish	alpha5 appl1 assembles cargoes deafness dimerizing drd2 factorbeta gh1 gh2 gipc gipc1 gipc2 gipc3 gipcs gpcrs hbc lrp1 myo6 nonsyndromic nrp1 ntrk1 pdz rgs19 rtks sdc4 sema4c tgfbetar3 vangl2
Tagcloud (Intersection) ?