SH3GL3 and RPL35A

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid, two hybrid)
HPRD (two hybrid)

		SH3GL3	RPL35A
Description		SH3 domain containing GRB2 like 3, endophilin A3	ribosomal protein L35a
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GO Annotations	Cellular Component	Acrosomal Vesicle Cytoplasm Endosome Early Endosome Membrane Early Endosome Membrane Presynapse Postsynaptic Endosome Glutamatergic Synapse Postsynaptic Density, Intracellular Component	Cytoplasm Cytosol Ribosome Membrane Cytosolic Large Ribosomal Subunit Cytosolic Ribosome Synapse Extracellular Exosome Ribonucleoprotein Complex
	Molecular Function	Protein Binding Lipid Binding Identical Protein Binding	TRNA Binding RNA Binding Structural Constituent Of Ribosome Protein Binding
	Biological Process	Endocytosis Signal Transduction Central Nervous System Development Positive Regulation Of Neuron Differentiation Negative Regulation Of Clathrin-dependent Endocytosis Regulation Of Clathrin-dependent Endocytosis	Cytoplasmic Translation RRNA Processing Translation Ribosomal Large Subunit Biogenesis
Pathways		EGFR downregulation Negative regulation of MET activity Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis InlB-mediated entry of Listeria monocytogenes into host cell NGF-stimulated transcription	L13a-mediated translational silencing of Ceruloplasmin expression Peptide chain elongation SRP-dependent cotranslational protein targeting to membrane SRP-dependent cotranslational protein targeting to membrane Viral mRNA Translation Selenocysteine synthesis Major pathway of rRNA processing in the nucleolus and cytosol Formation of a pool of free 40S subunits GTP hydrolysis and joining of the 60S ribosomal subunit Eukaryotic Translation Termination Regulation of expression of SLITs and ROBOs Response of EIF2AK4 (GCN2) to amino acid deficiency Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide Ribosome Quality Control (RQC) complex extracts and degrades nascent peptide PELO:HBS1L and ABCE1 dissociate a ribosome on a non-stop mRNA ZNF598 and the Ribosome-associated Quality Trigger (RQT) complex dissociate a ribosome stalled on a no-go mRNA
Drugs
Diseases			Diamond-Blackfan anemia (DBA)
GWAS		A body shape index ( 34021172) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Estimated glomerular filtration rate after 5 years in renal transplantation (recipient effect) ( 30920136) FEV1 ( 30804560) Gynecologic disease (multivariate analysis) ( 31488892) Height ( 18391951 28552196 25282103 20397748 18391950) Hip circumference adjusted for BMI ( 28552196 34021172) Hip index ( 34021172) Lung function (FEV1/FVC) ( 28166213 30804560) Proteinuria and chronic kidney disease ( 26420894) Smoking initiation ( 33082346) Spine bone size ( 31053729) Waist circumference adjusted for body mass index ( 34021172) Working memory ( 31598132)	Metabolite levels ( 23823483)
Interacting Genes		52 interacting genes: ADRB1 ANTKMT ARHGDIA ARHGEF6 ATXN2 C11orf68 C4orf17 CALCOCO1 CBLC CD101 CRIP1 DNAJC5 DNM1 DPPA4 DPYSL4 EGFL6 EGFR EMD FASLG FBXO32 GABBR2 GOLT1B HTT LRRK2 NDUFB9 PDCD6IP PIAS4 PTPRO QTRT1 RABAC1 RBM48 RER1 RNF8 RPL35A SEPTIN8 SH3D19 SH3GL1 SH3GL2 SH3KBP1 SHANK3 SHC3 SNRPN SNX24 SYNJ1 TERF1 TLE5 TMEM120B TNNT1 TOE1 VIM WASL WDR33	2 interacting genes: RAD21 SH3GL3
Entrez ID		6457	6165
HPRD ID		04528	01596
Ensembl ID		ENSG00000140600	ENSG00000182899
Uniprot IDs		Q99963	P18077
PDB IDs		2EW3 2Z0V	4UG0 4V6X 5AJ0 5LKS 5T2C 6IP5 6IP6 6IP8 6LQM 6LSR 6LSS 6LU8 6OLE 6OLF 6OLG 6OLI 6OLZ 6OM0 6OM7 6QZP 6W6L 6XA1 6Y0G 6Y2L 6Y57 6Y6X 6Z6L 6Z6M 6Z6N 6ZM7 6ZME 6ZMI 6ZMO 7BHP 7F5S 7OW7 7QVP 7XNX 7XNY 8A3D 8FKP 8FKQ 8FKR 8FKS 8FKT 8FKU 8FKV 8FKW 8FKX 8FKY 8FKZ 8FL0 8FL2 8FL3 8FL4 8FL6 8FL7 8FL9 8FLA 8FLB 8FLC 8FLD 8FLE 8FLF 8G5Y 8G5Z 8G60 8G61 8G6J 8GLP 8IDT 8IDY 8IE3 8IFD 8IFE 8INE 8INF 8INK 8IPD 8IPX 8IPY 8IR1 8IR3 8JDJ 8JDK 8JDL 8JDM 8K2C 8OHD 8OJ0 8OJ5 8OJ8 8QFD 8QOI 8QYX 8RL2 8UKB 8XSX 8XSY 8XSZ 8Y0W 8Y0X 8YOO 8YOP 9C3H 9G8M 9GMO
Enriched GO Terms of Interacting Partners?		Presynapse Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of ERBB Signaling Pathway Negative Regulation Of Epidermal Growth Factor Receptor Signaling Pathway Regulation Of CAMKK-AMPK Signaling Cascade Presynaptic Cytosol Central Nervous System Development Cytoplasmic Side Of Mitochondrial Outer Membrane Cytoplasm Negative Regulation Of ERBB Signaling Pathway Cytoplasmic Vesicle Hydrolase Activity, Acting On Carbon-nitrogen (but Not Peptide) Bonds, In Cyclic Amides Vocal Learning Observational Learning Synapse	Cohesin Complex Establishment Of Meiotic Sister Chromatid Cohesion Meiotic Cohesin Complex Establishment Of Mitotic Sister Chromatid Cohesion Replication-born Double-strand Break Repair Via Sister Chromatid Exchange Mitotic Cohesin Complex Postsynaptic Endosome Negative Regulation Of Clathrin-dependent Endocytosis Establishment Of Sister Chromatid Cohesion Negative Regulation Of Glial Cell Apoptotic Process Positive Regulation Of Sister Chromatid Cohesion Negative Regulation Of Cellular Component Organization Regulation Of Sister Chromatid Cohesion Chromatin Looping Postsynaptic Density, Intracellular Component Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Interleukin-10 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Mitotic Metaphase/anaphase Transition LncRNA Binding Sister Chromatid Cohesion Reciprocal Meiotic Recombination Homologous Recombination Negative Regulation Of Mitotic Nuclear Division Negative Regulation Of Interleukin-1 Production Negative Regulation Of Receptor-mediated Endocytosis Condensed Nuclear Chromosome Protein Localization To Chromatin Regulation Of Mitotic Sister Chromatid Separation Negative Regulation Of Tumor Necrosis Factor Production Regulation Of Interleukin-10 Production Negative Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Negative Regulation Of Endocytosis Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Chromosome Separation Negative Regulation Of Chromosome Organization Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of Neuron Differentiation Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Interleukin-1 Beta Production Regulation Of Sister Chromatid Segregation Protein Localization To Chromosome Positive Regulation Of Chromosome Organization Regulation Of G2/M Transition Of Mitotic Cell Cycle Acrosomal Vesicle Regulation Of Interleukin-1 Production Regulation Of Cell Cycle G2/M Phase Transition Regulation Of Mitotic Nuclear Division Regulation Of Receptor-mediated Endocytosis
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